Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 7:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Arch Toxicol. 2024 Mar 9. doi: 10.1007/s00204-024-03713-6. Online ahead of print.ABSTRACTThat certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through non-sperm-specific mechanisms-seminal plasma and circulating factors-that create 'imprinted' memory of ancestral information. ...
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Di Wu Kejia Zhang Kaifeng Guan Faheem Ahmed Khan Nuruliarizki Shinta Pandupuspitasari Windu Negara Fei Sun Chunjie Huang Source Type: research
Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 7:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Arch Toxicol. 2024 Mar 9. doi: 10.1007/s00204-024-03713-6. Online ahead of print.ABSTRACTThat certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through non-sperm-specific mechanisms-seminal plasma and circulating factors-that create 'imprinted' memory of ancestral information. ...
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Di Wu Kejia Zhang Kaifeng Guan Faheem Ahmed Khan Nuruliarizki Shinta Pandupuspitasari Windu Negara Fei Sun Chunjie Huang Source Type: research
Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 7:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 7:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 7:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development
Drug Discov Today. 2024 Mar 8:103948. doi: 10.1016/j.drudis.2024.103948. Online ahead of print.ABSTRACTMaster protocol designs such as umbrella and basket studies allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and THEY have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, fo...
Source: Drug Discovery Today - March 9, 2024 Category: Drugs & Pharmacology Authors: Elena Peeva Anindita Banerjee Christopher Banfield Koshika Soma Jared Christensen Sandeep Menon Michael S Vincent Mikael Dolsten Source Type: research
Incidence and factors associated with stent dysfunction and pancreatitis after gastroduodenal stenting for malignant gastric outlet obstruction
Conclusions Deployment of the Niti-S pyloric/duodenal stent, with conformability even for angulated strictures, significantly reduced the incidence of SD. Stent selection, life expectancy, and MPD caliber should be taken into consideration during decision-making for GDS deployment for mGOO. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - March 7, 2024 Category: Gastroenterology Authors: Yamashige, Daiki Hijioka, Susumu Nagashio, Yoshikuni Maruki, Yuta Fukuda, Soma Yagi, Shin Okamoto, Kohei Hara, Hidenobu Hagiwara, Yuya Agarie, Daiki Takasaki, Tetsuro Chatto, Mark Ohba, Akihiro Kondo, Shunsuke Morizane, Chigusa Ueno, Hideki Sone, Miyuki S Tags: Original article Source Type: research
Synthesis of cellulosic and nano-cellulosic aerogel from lignocellulosic materials for diverse sustainable applications: a review
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - March 5, 2024 Category: Biochemistry Authors: Ganguly, Anisha Nag, Soma Gayen, Kalyan Source Type: research
A Promise to a Sustainable Future: 10 Years of the Green Chemistry Commitment at Beyond Benign
Green Chem., 2024, Accepted Manuscript DOI: 10.1039/D4GC00575A, PerspectiveAmy Cannon, John Warner, Juliana Vidal, Natalie O'Neil, Monica Mame Soma Nyansa, Nimrat Obhi, Jonathon W. Moir Green chemistry education is a fundamental tool for the achievement of a sustainable future at the molecular level. It allows the development of a scientific workforce and knowledgeable citizenry with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - March 4, 2024 Category: Chemistry Authors: Amy Cannon Source Type: research
Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability
This study demonstrates that IL-1β is critical for the regional heterogeneity of synaptic displacement by coordinating different actions of neurons and microglia via IL-1R1, which impacts both neural network homeostasis and motor learning ability. It provides a theoretical basis for elucidating the physiological role and mechanism of microglial displacement of GABAergic synapses.PMID:38438808 | DOI:10.1007/s00018-023-05111-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2024 Category: Cytology Authors: Yi You Da-Dao An Yu-Shan Wan Bai-Xiu Zheng Hai-Bin Dai She-Hong Zhang Xiang-Nan Zhang Rong-Rong Wang Peng Shi Mingjuan Jin Yi Wang Lei Jiang Zhong Chen Wei-Wei Hu Source Type: research
Skin dose-volume predictors of moderate-severe late side effects after whole breast radiotherapy
CONCLUSIONS: The association between late reactions and skin DVH when delivering 40 Gy/15 fr was quantified, suggesting an independent role of V20 and V42. Few clinical factors heavily modulate the risk.PMID:38423138 | DOI:10.1016/j.radonc.2024.110183 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 29, 2024 Category: Radiology Authors: Alessandro Cicchetti Paola Mangili Andrei Fodor Maria Giulia Ubeira Gabellini Anna Chiara Chiara Deantoni Martina Mori Marcella Pasetti Gabriele Palazzo Tiziana Rancati Antonella Del Vecchio Nadia Gisella Di Muzio Claudio Fiorino Source Type: research
Genetic and histological analysis intraplacental choriocarcinoma: a case report
We report on single case of intraplacental choriocarcinoma (IC) coexisting with feto-maternal hemorrhage from our hospital, a rare malignant tumor that occurs in the chorionic villous trophoblast. To investigate genetic and epigenetic changes to the carcinogenesis of IC, we employed cancer gene panel analysis and whole methylation analysis from a recent case of IC. By Short Tandem Repeats analysis, we confirmed that the tumor of present IC was derived from concurrent normal chorionic villous trophoblast cells. No mutation was found in 145 cancer-related genes. Meanwhile, amplification in MDM2 gene was observed. Furthermore...
Source: Molecular Medicine - February 29, 2024 Category: Molecular Biology Authors: Natsuko Takano Masashi Takamura Yosuke Mizuno Yumi Mizuno Shunsuke Tamaru Kohei Nakamura Hiroaki Soma Takeshi Kajihara Source Type: research
