Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability

This study demonstrates that IL-1β is critical for the regional heterogeneity of synaptic displacement by coordinating different actions of neurons and microglia via IL-1R1, which impacts both neural network homeostasis and motor learning ability. It provides a theoretical basis for elucidating the physiological role and mechanism of microglial displacement of GABAergic synapses.PMID:38438808 | DOI:10.1007/s00018-023-05111-0

Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2024 Category: Cytology Authors: Yi You Da-Dao An Yu-Shan Wan Bai-Xiu Zheng Hai-Bin Dai She-Hong Zhang Xiang-Nan Zhang Rong-Rong Wang Peng Shi Mingjuan Jin Yi Wang Lei Jiang Zhong Chen Wei-Wei Hu Source Type: research