Motor learning changes the axon initial segment of the spinal motoneuron
J Physiol. 2024 Apr 3. doi: 10.1113/JP283875. Online ahead of print.ABSTRACTWe are studying the mechanisms of H-reflex operant conditioning, a simple form of learning. Modelling studies in the literature and our previous data suggested that changes in the axon initial segment (AIS) might contribute. To explore this, we used blinded quantitative histological and immunohistochemical methods to study in adult rats the impact of H-reflex conditioning on the AIS of the spinal motoneuron that produces the reflex. Successful, but not unsuccessful, H-reflex up-conditioning was associated with greater AIS length and distance from s...
Source: The Journal of Physiology - April 3, 2024 Category: Physiology Authors: Yu Wang Yi Chen Lu Chen Bruce J Herron Xiang Yang Chen Jonathan R Wolpaw Source Type: research
Clinical Features in Adolescent and Adult Cases with Pulmonary Hypertension Associated with Congenital Portosystemic Shunt
Purpose: Congenital portosystemic shunts (CPSS) are rare vascular malformations which cause partial or complete shunting of portal blood into the systemic circulation. Pulmonary arterial hypertension (PAH) is one of its major complications, and therapeutic outcomes for children have been reported. However, clinical courses of CPSS-related PAH in adolescent and adult cases are not well known. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Hatano, S. Minatsuki, S. Ando, K. Hirose, A. Saito, H. Yagi, M. Shimbo, K. Soma, C. Konoeda, M. Sato Source Type: research
Fibroblast Growth Factor Receptor 3 Autoantibodies Induce Hyperexcitability in Sensory Neurons and Pain Behaviors
Small fiber neuropathies (SFN) result from primary degeneration of the sensory neurons of the dorsal root ganglia (DRG), more specifically, the A δ (mechanoreceptors) and unmyelinated C-fibers (nociceptors). The clinical presentation is often symmetric and can present as a painful length-dependent sensory predominant polyneuropathy. Here, we utilize autoantibodies against fibroblast growth factor receptor 3 (FGFR3) as a biological marker of a population of patients with SNN and SFN. We have found that FGFR3 autoantibodies bind neuronal soma within rat dorsal root ganglia (DRG), confirming FGFR3 expression in the primary a...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Lyuba Salih, Nicolas Dumaire, Christine Kim, Liberty Francois-Moutal, Aubin Moutal Source Type: research
Comparative analysis of two dose-volume histogram prediction tools for treatment planning in volumetric-modulated arc therapy: A multi-planner study
This study explored the use of dose-volume histogram (DVH) prediction tools to address these disparities, specifically focusing on RapidPlan (Varian Medical Systems) and PlanIQ (Sun Nuclear). RapidPlan predicts achievable DVHs and automatically generates optimization objectives. (Source: Medical Dosimetry)
Source: Medical Dosimetry - March 30, 2024 Category: Radiology Authors: Motoharu Sasaki, Yuji Nakaguchi, Takeshi Kamomae, Akira Tsuzuki, Soma Sawada, Koki Shibuya, Masataka Oita, Masahide Tominaga, Yuki Tominaga, Hitoshi Ikushima Tags: Research Article Source Type: research
Real ‐Time and High‐Resolution Monitoring of Neuronal Electrical Activity and pH Variations Based on the Co‐Integration of Nanoelectrodes and Chem‐FinFETs
An innovative bio-platform is introduced, integrating two classes of 3D sensors with functional nanostructures to monitor in vitro neural networks. This platform enables simultaneous recording of electrical activity in primary rat cortical neurons using passive vertical nanoprobes, along with localized pH changes utilizing Chem-FinFETs. AbstractDeveloping new approaches amenable to the measurement of neuronal physiology in real-time is a very active field of investigation, as it will offer improved methods to assess the impact of diverse insults on neuronal homeostasis. Here, the development of an in vitro bio platform is ...
Source: Small - March 29, 2024 Category: Nanotechnology Authors: Luca Bettamin,
Fabrice Mathieu,
Florent H. Marty,
Marie Charline Blatche,
Daniel Gonzalez ‐Dunia,
Elsa Suberbielle,
Guilhem Larrieu Tags: Research Article Source Type: research
Intermittent fasting improves the oocyte quality of obese mice through the regulation of maternal mRNA storage and translation by LSM14B
Free Radic Biol Med. 2024 Mar 27:S0891-5849(24)00158-8. doi: 10.1016/j.freeradbiomed.2024.03.021. Online ahead of print.ABSTRACTObesity has significant repercussions for female reproductive health, including adverse effects on oocyte quality, fertility, embryo development and offspring health. Here, we showed that intermittent fasting (IF) has several notable effects on follicular development, oocyte development and maturation and offspring health in obese mice. IF treatment prevents obesity-associated germline-soma communication defects, mitochondrial dysfunction, oxidative damage, apoptosis, and spindle/chromosomal disru...
Source: Free Radical Biology and Medicine - March 29, 2024 Category: Biology Authors: Chan Li Hui Zhang Hao Wu Jingmei Li Qingyang Liu Yanxue Li Menghao Pan Xiaoe Zhao Qiang Wei Sha Peng Baohua Ma Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in < em > Cntnap2 < /em > KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research
