Handheld 3D Bioink Printer for Wound Healing
Researchers at the University of Toronto have developed a handheld 3D printer that can deposit a stem cell-loaded bioink onto wounds, such as burns, to promote tissue healing. The device acts like a paint roller, and a clinician could use it to deposit the biomaterial in even stripes on a wound surface. A recent study has shown that the deposited bioink can help tissue to heal. The researchers hope that the technique could help to heal large burns for which it is difficult to use skin grafts.
At present, skin grafts are employed to replace tissue lost in burns. However, for large burns that cover much of the body, findi...
Source: Medgadget - February 5, 2020 Category: Medical Devices Authors: Conn Hastings Tags: News Plastic Surgery Source Type: blogs
Fight Aging! Newsletter, November 11th 2019
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health.
Towards a Rigorous Definition of Cellular Senescence
https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/
The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the producti...
Source: Fight Aging! - November 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
3-D Printing of Skin with Embedded Vasculature
Researchers continue to take incremental steps towards the creation of engineered living tissues containing the vascular networks needed to support it. Absent blood vessels, numerous varieties of functional tissue can be generated from cell samples: lung, liver, kidney, and so forth. These organoids are limited in size to a few millimeters, however, the distance the nutrients and oxygen can perfuse. Generating blood vessel networks is a serious technical challenge, and the major obstacle to the production of entire organs for transplantation. Consider that natural capillary networks exhibit a density of hundreds of vessels...
Source: Fight Aging! - November 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Scientists 3D Print Vascularized Artificial Skin
Researchers from Rensselaer Polytechnic Institute have developed a new method to 3D print living skin with built-in blood vessels. This living skin construct is cultured in vitro and develops into an interconnected microvascular network underneath a layered barrier of skin cells. in tests on mice, the grafts connect with the animals’ vascular network and become perfused within four weeks after transplantation. This exciting development may one day provide new, more functional skin grafts for patients.
Current artificial skin grafts can fall off due to their lack of integration with the host cells. One of the major...
Source: Medgadget - November 4, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, October 7th 2019
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone.
Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the...
Source: Fight Aging! - October 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Vitiligo: More than skin deep
Vitiligo (pronounced vit-uh-LIE-go) is a medical condition in which patches of skin lose their color. This occurs when melanocytes, the cells responsible for making skin pigment, are destroyed. Vitiligo can affect any part of the body, and it can occur in people of any age, ethnicity, or sex.
Affecting approximately 1% of the population, vitiligo can be an emotionally and socially devastating disease. Particularly frustrating to many is its unpredictable progression, which can be slow or rapid.
Thus far, there is no cure for vitiligo. But new hope is on the horizon, thanks to recent research that is improving our understan...
Source: Harvard Health Blog - September 26, 2019 Category: Consumer Health News Authors: Kristina Liu, MD, MHS Tags: Autoimmune diseases Health Skin and Hair Care Source Type: blogs
Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined.
Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Printing Skin, Bones for Surgeries on Way to Mars
Traveling to Mars, our closest planet and which may one day serve as another base for humanity, is very far away. Any practical mission there and back will take years. The health of the astronauts undertaking such a journey will be paramount, so researchers are working on ways to be able to create customized tissues in space. This ability would give astronauts a way to restore damaged or diseased tissues, an ability that would also certainly be nice to have down here on Earth.
At the University Hospital of Dresden Technical University, researchers working with OHB Systems AG and Blue Horizon, two firms involved in topic...
Source: Medgadget - July 10, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Plastic Surgery Rehab Space Medicine Source Type: blogs
Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing.
Altered Intercellular Communication
It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool.
In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 12, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bioprinting Skin Directly Onto a Wound
Bioprinting directly onto the body seems a logical evolution of the state of the art in this part of the field, given the emerging ability to bioprint full thickness skin, or at least a living structure very close to that. It is interesting to consider how bioprinting in situ could be made to work for internal organs. We might envisage something akin to keyhole surgery with a machine-guided printing head. The easier initial applications might include printing a patch of tissue directly onto the heart, akin to the present development of heart patches that are grown outside the body and then transplanted. The Lygenesis appro...
Source: Fight Aging! - March 7, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Thinking about rhinoplasty?
A rhinoplasty, or nose job, is surgery performed to alter the way your nose functions and looks. According to the American Society of Plastic Surgeons, nearly 220,000 rhinoplasties are performed yearly, making this the most common facial plastic surgery procedure. Rhinoplasty can simultaneously help you improve breathing and achieve a more balanced appearance.
Is rhinoplasty right for me?
A common medical reason for rhinoplasty is difficulty breathing through the nose. Nasal obstruction can cause problems with exercise, disturb sleep, contribute to snoring and sleep apnea, or interfere with other activities. If medical tre...
Source: Harvard Health Blog - March 6, 2019 Category: Consumer Health News Authors: David A. Shaye, MD, MPH Tags: Cosmetic surgery Ear, nose, and throat Source Type: blogs
Nanoparticles Highlight Organ Transplant Rejection Through Fluorescent Urine
Researchers at Georgia Tech have developed a sophisticated nanoparticle that can alert clinicians to the early stages of transplanted organ immune rejection through a simple urine test. The nanoparticles can accumulate in transplanted organs and detect immune rejection, whereupon they release molecules that turn the urine of the organ recipient fluorescent. Using a simple urine test, clinicians can then assess if organ rejection is happening, potentially replacing the need for invasive biopsies.
Organ transplantation provides organ recipients with a new lease of life, but it is not without risks and complications. One of t...
Source: Medgadget - February 21, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Nanomedicine Surgery Source Type: blogs
Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Wary of the Beautiful Fairy Tale of Near Term Rejuvenation
https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/
One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev....
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 31st 2018
In conclusion, there are many anti-aging strategies in development, some of which have shown considerable promise for slowing down aging or delaying the onset of age-related diseases. From multiple pre-clinical studies, it appears that upregulation of autophagy through autophagy enhancers, elimination of senescent cells using senolytics, transfusion of plasma from young blood, neurogenesis and BDNF enhancement through specific drugs are promising approaches to sustain normal health during aging and also to postpone age-related diseases. However, these approaches will require critical assessment in clinical trials to determ...
Source: Fight Aging! - December 30, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
