Scientists 3D Print Vascularized Artificial Skin

Researchers from Rensselaer Polytechnic Institute have developed a new method to 3D print living skin with built-in blood vessels. This living skin construct is cultured in vitro and develops into an interconnected microvascular network underneath a ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs

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Abstract Healing in wounds like pressure ulcers, diabetic ulcers, venous ulcers, and arterial insufficiency ulcers is immensely hampered and causes both economic burden and morbidity to patients. These wounds face plethora of hostile conditions like elevated reactive oxygen species (ROS), impaired angiogenesis, senescent fibroblast and deficient stem cells that significantly diminish the probability of self-healing in these wounds. Adipose-derived stem cell therapy (ADSC) presents a promising approach to achieve efficient healing in such cases. To address the complex scenario of chronic wounds, we propose a combin...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
ConclusionThe combination use could enhance the recovery of DFUs, shorten the treatment duration, and reduce the pain during treatment.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
ConclusionThis overview illustrated that either systematic reviews or the included RCTs had wide variety of quality and heterogeneity in order to provide high level of evidence. Hence, well-designed RCTs as well as meta-analysis are required to shade the light on different aspects of NPWT.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
This study suggests that the concentrated secretome of human MSCs can reverse the inhibitory effect of hypoxia and low serum on keratinocyte proliferation and migration. This phenomenon may contribute to the beneficial effects of hMSC-CM on wound healing in vivo. PMID: 31761327 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Earlier this year, Medgadget reported on the FDA’s clearance of the SEM Scanner, a device created by Los Angeles-based Bruin Biometrics (BBI). The SEM Scanner is a wireless, handheld device that detects changes in sub-epidermal moisture as an i...
Source: Medgadget - Category: Medical Devices Authors: Tags: Critical Care Exclusive Medicine Plastic Surgery Vascular Surgery Source Type: blogs
Authors: Namgoong S, Jung SY, Han SK, Kim AR, Dhong ES Abstract Current treatment guidelines for biofilm-associated infections (BAI) recommend repeated sharp/surgical debridement followed by treatment with antimicrobial agents until the wound becomes self-sustaining in terms of a positive wound-healing trajectory. However, complete removal of a biofilm is unlikely, and biofilms reform rapidly. We have treated BAI in patients with chronic diabetic ulcers using a meshed skin graft combined with negative pressure wound therapy (NPWT) immediately after surgical debridement, rather than waiting until the development of ...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
DISCUSSION: The identified preoperative factors and postoperative complications should help guide quality improvement programs. PMID: 31567615 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Condition:   Diabetic Foot Ulcer Intervention:   Device: Negative Pressure Wound Therapy Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Pressure ulcers managed by coordinated nursing and weekly SLBTs appear to heal significantly faster than wounds managed by UC. Further studies are required to confirm these hypothesis-generating results. PMID: 31461401 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: These results showed length of surgery and intraoperative blood loss were independent risk factors for PU after liver resection with a long surgical duration. Use of PU prevention strategies are recommended for patients who undergo liver resection with massive intraoperative blood loss and long surgical duration. PMID: 31461399 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
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