Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, there are more reasons why the nonablative setting is preferable for old recipients. These are lesser risks of infections and of graft-vs-host disease, threatening to ablated patients, while graft rejection by nonablated recipients is less probable in the elderly than at a younger age because of naturally weaker immune system in the elderly. Even in the absence of histocompatibility, when allogeneic BM was used in a nonablative experiment instead of syngeneic BM, no lifespan shortening of the experimental group was observed. Obviously, at an old age the immune system is already too passive to reject donor BM, but it still efficiently suppresses infection and graft-vs.-host reaction, which makes it unnecessary and undesirable to use ablative conditioning in the elderly. On the bases of the above and our data, we advocate a more rapid implementation of ...
Pfizer has agreed to buy Array Biopharma in a $10.64 billion cash deal.
As researchers continue to hunt for ways to treat or prevent Alzheimer ’s disease, one study has shown promise in slowing the progression of the disease.
Cardiovascular disease (CVD) is often caused by modifiable risk factors related to diet and lifestyle behaviors. Counseling patients to adopt lifestyle changes for CVD risk-reduction is needed. Using the 5As strategy (ask, assess, advise, agree, assist) can help patients incorporate positive behavior changes and reduce CVD risk factors.
Children with asthma and recurrent wheezing can safely receive the nasal spray influenza vaccine, a large study found.Medscape Medical News
Nearly 6% of people in the study had a heart attack otrdeveloped angina (chest pain). The researchers found that all the people who developed heart trouble displayed a faster decline in their mental function at the same time.
ConclusionsPatients with PD and LIDs have abnormal cortical facilitation, possibly suggesting overactive glutamatergic neurotransmission in specific circuits within M1. Although not responsive to l-dopa, this dysfunction is restored by the anti-glutamatergic properties of safinamide 100 mg. The results suggest that the abnormal cortical facilitation in M1 contributes to the pathophysiology of LIDs.
Circadian rhythm disturbances in older adults may be markers of Alzheimer disease and its progression, new research suggests.Medscape Medical News
Patients who receive a diagnosis of coronary heart disease are at higher risk for cognitive decline later on, a new study shows.
Abstract The commercial production of high quality natural rubber (NR) solely depends on Hevea brasiliensis Muell. Arg, (Para rubber tree) and accounts for>98% of total production worldwide. NR with its unique properties is an essential commodity for the automobile industry and its synthetic counterparts are in no way substitute to it. The rubber tree genome is very complex and plays an important role in delivering the unique properties of Hevea. But a lack of knowledge on the molecular mechanisms of rubber biosynthesis, disease resistance, etc., in elite clones of rubber still persists. Marker-assisted selecti...
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