Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Oxygen-Releasing Bioink to Enhance Cell Survival in 3D Printed Structures
Researchers at the Terasaki Institute for Biomedical Innovation in Los Angeles, California have developed an oxygen-releasing bioink that may be useful in 3D printing bioengineered cell constructs. This can help live cells to survive in limited oxygen environments, such as those that exist inside of 3D printed devices, in the first days after implantation.
Heart cells in a bioink (top) without oxygen support and (bottom) with oxygen-releasing capabilities. Live cells are stained green, dead cells in red.
Developing cell-encapsulating constructs, consisting of regenerative cells in a supportive biomaterial matrix, hol...
Source: Medgadget - September 10, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Plastic Surgery Source Type: blogs
Electronic Skin Senses Pain, Temp, Pressure as Fast as Human Dermis
Scientists at the RMIT University in Melbourne, Australia have announced the development of an artificial skin material that can sense pain, temperature, and pressure. It’s remarkable because it replicates how real skin responds to stimuli, which sends appropriate electric signals through neural pathways to the brain. The technology is slated to allow for life-like transmission of tactile sensations through prosthetic arms and legs, and may even help replace skin grafts with artificial solutions.
According to RMIT, the electronic skin “replicates” how our native skin detects pain, sending out signals j...
Source: Medgadget - September 3, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Materials News Rehab Source Type: blogs
Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rat Livers Decellularized, then Recellularized with Human Cells and Transplanted
A decellularized organ is one that has had the cells stripped out, such as via detergent solutions, leaving behind the extracellular matrix. Decellularization is a way to obtain a fully detailed organ scaffold, complete with chemical cues to guide the reconstruction of tissues when new cells are added, without having to build it from scratch. That task that is presently impossible, though some groups are making headway in the construction of scaffolds detailed enough for use in tissue engineering. Interestingly, decellularization allows the use of human cells in animal organs: this may be a viable path towards farming pigs...
Source: Fight Aging! - June 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Transplanted Neurons Derived From Induced Pluripotent Stem Cells Restore Function Following Stroke in Rats
Like much of the nervous system, the brain doesn't regenerate well at all. Lost cells remain lost, and lost function is often permanent. One of the most important goals in the field of regenerative medicine is repair of the brain, which might be achieved in the decades ahead via delivery of new neurons that can integrate with existing neural circuits. Far from being a class of therapy only deployed following evident injury such as the aftermath of a stroke, this could take the form of periodic treatments that maintain the brain by repairing the lesser damage and loss of neurons that accumulates in an ongoing fashion over a...
Source: Fight Aging! - April 15, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Prosthetic Tech Lets Users Control Individual Fingers on First Try
Existing prosthetic hands have to rely on weak electrical nerve signals in order to know when to activate their motors. That’s because electrodes are typically placed on the skin over the area where the nerves end at the stump and the skin doesn’t transmit electricity that well. Implantable electrodes that make contact with the nerves tend to form scar tissue that ends up ruining signal fidelity and brain-computer interfaces are simply too invasive for most applications.
Now, researchers at the University of Michigan have come up with a way to significantly boost the power of nerve signals so that when they&...
Source: Medgadget - March 10, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Rehab Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
10 Ways Technology Is Changing Healthcare
The future of healthcare is shaping up in front of our very eyes with advances in digital technologies, such as artificial intelligence, VR/AR, 3D-printing, robotics or nanotechnology. We have to familiarize with the latest developments in order to be able to control technology and not the other way around. The future of healthcare lies in working hand-in-hand with technology and healthcare workers have to embrace emerging technologies in order to stay relevant in the coming years.
Be bold, curious and informed!
Are you afraid that robots will take over the jobs of nurses, doctors and other healthcare professionals? Are y...
Source: The Medical Futurist - March 3, 2020 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine 3d printing AI artificial intelligence augmented reality genetics Health Healthcare nanotechnology Personalized medicine pharma pharmacology robotics virtual reality wearables GC1 Source Type: blogs
Use of a Handheld Skin Printer Improves Regeneration of Burn Injuries
Miniaturizing bioprinters to allow finely controlled printing directly onto (or into) the body is an important logistical advance in this part of the tissue engineering field. It allows for a much more efficient approach to building up new tissue where needed, such as injured skin. Researchers here demonstrate that their implementation of a handheld skin printer accelerates regeneration of severe burn injuries in animal models, suggesting they are a fair way along the road to having something that can be converted into a viable product for widespread use.
A new handheld 3D printer can deposit sheets of skin to cov...
Source: Fight Aging! - March 2, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging
Thymic Involution Contributes to Immunosenescence and Inflammaging
The Potential for Exosome Therapies to Treat Sarcopenia
Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
The Aging Retina, a Mirror of the Aging Brain
Evidence for Loss of Capillary Density to be Important in Heart Disease
Aspects of Immune System Aging Proceed More Rapidly in Men
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Transplantation of Senescent Cel...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on the 2020 Longevity Therapeutics Conference in San Francisco
I recently attended the 2020 Longevity Therapeutics conference in San Francisco. I presented on the work ongoing at Repair Biotechnologies, but as is usually the case the more important parts of the visit took place outside the bounds of the conference proper. Longevity Therapeutics is one of the four or five core conferences for the longevity industry, at which you'll meet many of the early participants - a mix of scientists, entrepreneurs, and investors, and patient advocates. As such, most of the conference goers have already seen my updates, or are otherwise aware of the Repair Biotechnologies programs aimed at thymic ...
Source: Fight Aging! - February 10, 2020 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
