Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 19th 2022
Conclusion
Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life.
Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines.
Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivery of VEGF-A in Aged Skin as an Approach to Improve Function
Researchers here report on an investigation of mechanisms by which aged human skin is improved in function when transplanted onto young immunocompromised mice. They identified VEGF-A as a factor involved in this improvement, and showed that delivering VEGF-A to human skin models can reduce signatures of aging. This is interesting, as a number of skin conditions exhibit high levels of VEGF-A, and are treated by therapies that are shown to inhibit VEGF-A in addition to other effects. Thus more work is needed here in order to understand whether or not VEGF-A based treatments are a viable path to improving aged skin function.
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Source: Fight Aging! - July 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously p...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
3D Printing in Medicine And Healthcare – The Ultimate List In 2021
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. Just look at the impressive list of 3D printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained the technology in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of B...
Source: The Medical Futurist - July 13, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine bioprinting Innovation Video GC1 3d printed biomaterial tissue engineering Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mechanisms by Which Stem Cell Therapy Might Treat Skin Aging
There is some interest in the research community in targeting first generation stem cell therapies to the skin in order to reverse skin aging. These stem cell therapies use cells obtained from fat tissue or other well established sources, and in near all cases the transplanted cells near all die quite quickly following their introduction into the patient. Methods of cell production and sources of cells vary widely, and so do the observed benefits. Increased regeneration is widely claimed, but only intermittently proven. Benefits realized by patients largely derive from reductions in systemic inflammation and other effects ...
Source: Fight Aging! - May 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Placental Allografts for Diabetic Foot Ulcers: Interview with Tim Wright, CEO of MiMedx
MiMedx, a medtech company based in Georgia, has developed EpiFix, an off-the-shelf allograft system for the treatment of diabetic foot ulcers. The grafts are made using donated human placental tissues that are obtained from consenting mothers during caesarean section procedures. The tissues then undergo a proprietary processing procedure to clean them and eventually produce a dehydrated graft that can be stored at room temperature long term.
Diabetic foot ulcers are relatively common in patients with diabetes, presenting in as many as 15% of such patients. These wounds are stubborn and typically resistant to treatment, ...
Source: Medgadget - February 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Surgery Vascular Surgery Source Type: blogs
Fully Implantable LVAD for End-Stage Heart Failure: Interview with Greg S. Aber, CEO of Corvion
Patients with advanced heart failure often need a cardiac transplant due to the severe injuries sustained by the heart muscle.
Left Ventricular Assist Devices (LVADs) are frequently used in such patients to help the heart pump blood through the body while they are waiting for a transplant. These devices are also used in the short-term to support the hearts of patients who have had heart surgery, and are increasingly being employed as a long-term option for patients who cannot get a transplant.
Medgadget had an opportunity to speak to the Greg Aber, CEO of Corvion Inc., a company that has developed a fully implantab...
Source: Medgadget - February 12, 2021 Category: Medical Devices Authors: Rukmani Sridharan Tags: Cardiac Surgery Cardiology Exclusive Source Type: blogs
Medgadget ’s Best Medical Technologies of 2020
In conclusion, 2020 will certainly be remembered for a world stopped by an pandemic. It will also stand out as a time when people came together to innovate, adapt, and improve the world around them. We wish you all a happy New Year and look forward to better times ahead, together.
Flashbacks: Medgadget’s Best Medical Technologies of 2019; 2018; 2017; 2016; 2015 (Source: Medgadget)
Source: Medgadget - December 30, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
