“Shooting The Messenger” Is A Psychological Reality – Share Bad News And People Will Like You Less
By Matthew Warren
We all know the movie scene: a nervous aide has to deliver bad news to his villainous boss, stumbling over his words and incessantly apologising. For a second, it looks like he will be OK – until the boss turns around and summarily executes him.
But it turns out this phenomenon of “shooting the messenger” is not just restricted to fiction. A new paper in Journal of Experimental Psychology: General has demonstrated that we do tend to take a dim view of the bearers of bad news – even when these people are simply innocent messengers.
Previous work had already shown that we often form unfavourable ...
Source: BPS RESEARCH DIGEST - May 8, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Social Source Type: blogs
Fight Aging! Newsletter, May 6th 2019
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an ass...
Source: Fight Aging! - May 5, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Carolina Oliveira of OneSkin Technologies
OneSkin Technologies is one of the few companies in the present community of startups focused on rejuvenation and slowing aging to adopt a serious cosmetics focus on development. Here "cosmetics" is a regulatory term, not an indication of something used for the purposes of looks: it is perfectly possible for a topically applied product that is regulated as a cosmetic to have therapeutic effects, just like a drug. Nonetheless, cosmetics and drugs have entirely distinct paths of regulation, very different from one another, and each with their own costs and challenges. In regulated cosmetics development there is no animal tes...
Source: Fight Aging! - April 29, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
EnVisio Surgical Navigation System for Breast Lumpectomies Cleared in U.S.
Elucent Medical, a firm based in Eden Prairie, MN, won FDA clearance for its EnVisio Navigation System. The technology involves placing a wireless SmartClip implantable marker within the breast that identifies the location of the tissue to be removed. Normally guidewires are used to locate the target tissue, which extend out through the skin. The SmartClip marker remains completely implanted until the lumpectomy. It’s actually possible to use multiple SmartClips to target different locations within the breast, and this is aided by the fact that each of the implants has its own radiofrequency signature identifying it...
Source: Medgadget - April 12, 2019 Category: Medical Devices Authors: Editors Tags: Pathology Radiology Surgery Source Type: blogs
Bioprinting Skin Directly Onto a Wound
Bioprinting directly onto the body seems a logical evolution of the state of the art in this part of the field, given the emerging ability to bioprint full thickness skin, or at least a living structure very close to that. It is interesting to consider how bioprinting in situ could be made to work for internal organs. We might envisage something akin to keyhole surgery with a machine-guided printing head. The easier initial applications might include printing a patch of tissue directly onto the heart, akin to the present development of heart patches that are grown outside the body and then transplanted. The Lygenesis appro...
Source: Fight Aging! - March 7, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nanoparticles Highlight Organ Transplant Rejection Through Fluorescent Urine
Researchers at Georgia Tech have developed a sophisticated nanoparticle that can alert clinicians to the early stages of transplanted organ immune rejection through a simple urine test. The nanoparticles can accumulate in transplanted organs and detect immune rejection, whereupon they release molecules that turn the urine of the organ recipient fluorescent. Using a simple urine test, clinicians can then assess if organ rejection is happening, potentially replacing the need for invasive biopsies.
Organ transplantation provides organ recipients with a new lease of life, but it is not without risks and complications. One of t...
Source: Medgadget - February 21, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Nanomedicine Surgery Source Type: blogs
Case of the Week 528
This week ' s case was donated by Dr. Lars Westblade. The patient is a middle-aged man who recently returned from Tanzania. He presented with multiple furuncular lesions including the following:The patient saw a dermatologist who performed a skin biopsy. Here are representative sections (stained with hematoxylin and eosin):What is the diagnosis? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - January 22, 2019 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, December 31st 2018
In conclusion, there are many anti-aging strategies in development, some of which have shown considerable promise for slowing down aging or delaying the onset of age-related diseases. From multiple pre-clinical studies, it appears that upregulation of autophagy through autophagy enhancers, elimination of senescent cells using senolytics, transfusion of plasma from young blood, neurogenesis and BDNF enhancement through specific drugs are promising approaches to sustain normal health during aging and also to postpone age-related diseases. However, these approaches will require critical assessment in clinical trials to determ...
Source: Fight Aging! - December 30, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Selection of Recent Research into Biomarkers of Aging
If the research community had a reliable, low-cost method of quickly assessing biological age, the burden of damage and dysfunction, a measure that is distinct from chronological age, then progress towards rejuvenation therapies might be accomplished more rapidly. At present the only reliable way to determine whether or not a given therapy produces a slowing of aging or rejuvenation is to run expensive, slow life span studies in mice. Even when taking the approach of starting the study with old mice, this is still quite a lengthy undertaking. Being able to apply a putative rejuvenation therapy to mice (or dogs, or non-huma...
Source: Fight Aging! - December 27, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Immunohistochemistry in the Differential Diagnosis of Cutaneous Basal Cell Carcinoma
Basal cell carcinoma and squamous cell carcinoma are two of the most common cutaneous tumors seen by pathologists. In the large majority of cases, the distinction between these two tumors is readily made on the basis of standard H&E morphology. However, many of us see cases from time to time that for one reason or another (minuscule biopsy, mishandled specimen, crushed beyond recognition, dryed out, poorly fixed, etc., etc.), it is difficult to know for certain whether one is dealing with a squamous carcinoma or a basal cell carcinoma. This month, we discuss several immunostains that can be of utility in approaching th...
Source: Oncopathology - November 20, 2018 Category: Cancer & Oncology Source Type: blogs
Immunohistochemistry in the Differential Diagnosis of Cutaneous Basal Cell Carcinoma
Basal cell carcinoma and squamous cell carcinoma are two of the most common cutaneous tumors seen by pathologists. In the large majority of cases, the distinction between these two tumors is readily made on the basis of standard H&E morphology. However, many of us see cases from time to time that for one reason or another (minuscule biopsy, mishandled specimen, crushed beyond recognition, dryed out, poorly fixed, etc., etc.), it is difficult to know for certain whether one is dealing with a squamous carcinoma or a basal cell carcinoma. This month, we discuss several immunostains that can be of utility in approaching th...
Source: Oncopathology - November 20, 2018 Category: Cancer & Oncology Source Type: blogs
MKSAP: 34-year-old man with slow-growing lesions
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 34-year-old man is evaluated for several slow-growing lesions on his penis. He first noticed the wart-like growths 3 years ago, and they have progressively enlarged. He was treated with topical cryotherapy six times and topical imiquimod over the past year without improvement; the lesions have continued to enlarge. Medical history is significant for HIV infection. Medications are tenofovir, emtricitabine, and efavirenz.
On physical examination, vital signs are normal. Multiple red to brown verrucous papules wi...
Source: Kevin, M.D. - Medical Weblog - October 20, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Infectious Disease Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 8th 2018
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - October 7, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
