Understanding Leprosy on World Leprosy Day
Leprosy is a chronic and progressive disease that primarily affects the skin and peripheral nervous system. Leprosy has been with us for thousands of years. There is evidence of the disease as far back as 4000 BC, in ancient Egypt.[1] In 1873, Norwegian physician Dr. Gerhard Armauer Hansen discovered that leprosy was caused by a bacterium. [2] Today, we call this bacterium Mycobacterium leprae, and we often refer to leprosy as Hansen’s Disease, in honor of Dr. Hansen. While leprosy caused significant morbidity and mortality in the past, cases today are rare and are curable with proper treatment.
How Is Leprosy Transmitte...
Source: GIDEON blog - January 28, 2021 Category: Databases & Libraries Authors: Uri Blackman Tags: News Leprosy Source Type: blogs
Supporting Promising Medtech Firms: Interview with Paul Grand, CEO of MedTech Innovator
MedTech Innovator is a medical technology accelerator program that supports medtech companies in translating their technologies into beneficial products. Much of this support takes the form of competitions. At present, MedTech Innovator holds competitions in the US and Asia, and companies can apply to enter either competition depending on where their primary market will be. The competitions occur at conferences where companies pitch their technologies over several rounds.
The competitions allow companies to receive feedback and insights from industry leaders and during the year 2020, MedTech Innovator and partners provi...
Source: Medgadget - January 4, 2021 Category: Medical Devices Authors: Conn Hastings Tags: etc. Exclusive Source Type: blogs
Medgadget ’s Best Medical Technologies of 2020
In conclusion, 2020 will certainly be remembered for a world stopped by an pandemic. It will also stand out as a time when people came together to innovate, adapt, and improve the world around them. We wish you all a happy New Year and look forward to better times ahead, together.
Flashbacks: Medgadget’s Best Medical Technologies of 2019; 2018; 2017; 2016; 2015 (Source: Medgadget)
Source: Medgadget - December 30, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Data on OneSkin's Peptide 14, a Topical Senotherapeutic, in Human Skin Models and Skin Biopsies
You might recall that OneSkin recently launched a cosmetic product claimed to reduce levels of senescent cells in aged skin, as measured by the usual markers for cellular senescence, such as p16 expression and senescence-associated β-galactosidase. Removal of senescent cells is more or less literal rejuvenation, given that the accumulation of such cells drives chronic inflammation, tissue dysfunction, and degenerative aging. Clearance of a large fraction of senescent cells via senolytic drugs has been shown to extend life and turn back measures of aging in a number of animal studies.
The OneSkin product contains a ...
Source: Fight Aging! - November 6, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is There a COVID-Related Wound?
A variety of skin lesions have been described with Coronavirus infection, also called COVID-19 or SARS-CoV-2, and this post explores whether there is a link between COVID and wounds. Understanding of this disease is still in the early stages, and it is unclear whether these skin lesions are the result of comorbidities or coinfection with other agents, or whether COVID-19 is actually responsible. A search of the world literature reveals the following skin issues with COVID:
Acral erythema (redness and swelling of the hands and feet) with vesicles and pustules. This is similar to chilblains – a condition associated with...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 21, 2020 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores coronavirus COVID COVID-19 decubiti decubitus ulcer end-of-life care eschar geriatrics gerontology Improving Medical Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests.
We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The OneSkin Technologies DNA Methylation Clock for Assessment of Skin Aging
OneSkin Technologies is one of the first generation of startup biotech companies in the longevity industry; you'll find an overview of their programs and technology in an interview with founder Carolina Reis last year. In summary, OneSkin works on both improved models of aging skin, and topical senolytic compounds capable of selectively destroying the senescent cells thought to be responsible for a sizable fraction of skin aging in later life. Unlike other companies in the longevity industry, the OneSkin staff is focused on the cosmetics regulatory path to market. This is in some ways more limited, and in other ways much c...
Source: Fight Aging! - July 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The doctor will “see” you now: Teledermatology in the era of COVID-19
The COVID-19 pandemic has transformed healthcare delivery across the world. Headlines about shortages of lifesaving resources and personal protective equipment have dominated our attention. But patients and doctors are also facing quieter challenges. Social distancing measures and concerns about transmission of the virus have significantly reduced the number of patients coming into hospitals and doctors’ offices for non-COVID-related health concerns — sometimes at a significant detriment to their health — due to delays in diagnosis or treatment.
In response, hospitals and clinics are increasingly turning to telemedic...
Source: Harvard Health Blog - June 4, 2020 Category: Consumer Health News Authors: Kristina Liu, MD, MHS Tags: Coronavirus and COVID-19 Health trends Skin and Hair Care Source Type: blogs
Reducing your risk of changes in thinking following surgery
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery.
Older adults are having more surgical procedures
As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - May 22, 2020 Category: Consumer Health News Authors: Subramaniam Balachundhar, MD, MPH, FASA Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
Reinventing Clinical Decision Support
In our latest book,Reinventing Clinical Decision Support: Data Analytics, Artificial Intelligence, and Diagnostic Reasoning, Paul Cerrato and I explore the promise of artificial intelligence and machine learning for improving clinicians ’ ability to make more informed diagnostic and therapeutic decisions. Here’s an excerpt from Chapter 2:“AI is a once-in-a-generation transformative technology. As such, expect its impact to be on the scale of the advent of electricity or the Internet,” says Jean-Claude Saghbini, Wolters Kluwer Health.(1)“Artificial intelligence and machine learning are set to transform healthcare....
Source: Life as a Healthcare CIO - April 24, 2020 Category: Information Technology Source Type: blogs
