Senescent Cells in Skin Contribute to the Formation of Age Spots, and Can be Destroyed by Radiofrequency Treatment
In this study, we reveal what we believe is a novel mechanism whereby aged fibroblasts contribute to the local regulation of melanogenesis. We show that as an individual ages, pigmented skin contains an increasing proportion of senescent fibroblasts. Phenotype switching in these cells results in the loss of SDF1, and SDF1 deficiency appears to be a potent stimulus for the melanogenic processes that contribute to uneven pigmentation. These changes might be epigenetic. For example, the level of hypermethylation of the SDF1 promoter was remarkably different between hyperpigmented and perilesional skin.
The human skin,...
Source: Fight Aging! - October 5, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is Practicing on a Cadaver the Best Way to Develop Ultrasound Skills?
Medical students and radiology residents at the University of Arkansas for Medical Sciences are turning to lightly embalmed cadavers to fine tune and master their ultrasound-guided procedure skills.In their studypublished inAcademic Radiology, the group of researchers led by Mary E. Meek, MD, associate professor of radiology, had first-year medical students practice placing the needle and dilating the tissues on cadavers that had been deceased for three days. The bodies were threaded with wires and catheters on both access points. The cadavers were arranged in the seated positions and had been injected with Lidocaine. Ra...
Source: radRounds - July 27, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 009
The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
The Lie of Precision Medicine
My next blog post will be entitled " The Lie of Precision Medicine "— sarcastic_f (@sarcastic_f)June 23, 2018This post will be my own personalized rant about the false promises of personalized medicine. It will not be about neurological or psychiatric diseases, the typical topics for this blog. It will be about oncology, for very personal reasons: misery, frustration, and grief. After seven months of research on immunotherapy clinical trials, I couldn ' t find a single [acceptable] one1 in either Canada or the US that would enroll my partner with stage 4 cancer. For arbitrary reasons, for financial reasons, because ...
Source: The Neurocritic - June 24, 2018 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Tropical Travel Trouble 008 Total TB Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 008
Peer Reviewer Dr McBride ID physician, Wisconsin
TB affects 1/3rd of the population and one patient dies every 20 seconds from TB. Without treatment 50% of pulmonary TB patients will be dead in 5 years. In low to middle income countries both TB and HIV can be ubiquitous, poor compliance can lead to drug resistance and malnourished infants are highly susceptible. TB can be very complex and this post will hopefully give you the backbone to TB m...
Source: Life in the Fast Lane - June 16, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine Genexpert meningitis TB TB meningitis Tuberculosis Source Type: blogs
MKSAP: 28-year-old man with lower-extremity edema
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 28-year-old man is evaluated for a 2-month history of progressive lower-extremity edema, weight loss, and fatigue. Medical history is significant for recreational use of inhaled cocaine; he denies injection drug use. He has no other known medical issues and takes no medications.
On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 130/90 mm Hg, pulse rate is 90/min, and respiration rate is 20/min. BMI is 28. Temporal wasting is present. The lungs are clear. Cardiac examination is norm...
Source: Kevin, M.D. - Medical Weblog - May 19, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Infectious Disease Nephrology Source Type: blogs
Fight Aging! Newsletter, April 30th 2018
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
Recent Research on the Benefits of Exercise in Later Life
https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/
A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case...
Source: Fight Aging! - April 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 26th 2018
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - March 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in the Cardiovascular and Metabolic Diseases of Aging
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - March 23, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 12th 2018
This study identifies the missing link between Lewy bodies and the type of damage that's been observed in neurons affected by Parkinson's. Parkinson's is a disorder of the mitochondria, and we discovered how Lewy bodies are releasing a partial break-down product that has a high tropism for the mitochondria and destroys their ability to produce energy."
Lewy bodies were described a century ago, but it was not until 1997 that scientists discovered they were made of clumps of a misfolded protein called α-synuclein. When it's not misfolded, α-synuclein is believed to carry out functions related to the transmission of...
Source: Fight Aging! - March 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MKSAP: 50-year-old man with a firm, darkly pigmented papule
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 50-year-old man is evaluated for a firm, darkly pigmented papule on his back that has been growing steadily over a period of several months. His medical history is unremarkable, and he takes no medications.
On physical examination, vital signs are normal. The skin lesion is a 0.5-cm darkly pigmented, raised plaque with irregular borders and inconsistent coloration. The remainder of his physical examination, including the rest of his skin examination, is unremarkable.
A skin biopsy is performed and shows malign...
Source: Kevin, M.D. - Medical Weblog - March 10, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Dermatology Oncology/Hematology Source Type: blogs
How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Senolytic Peptide FOXO4-DRI
The objective is to wind up with the right amount of FOXO4-DRI dissolved in phosphate buffered saline in a sealed vial, ready to be used with the injection system, and with as little contamination as possible from the environment. Depending on the size of the vial, it might contain doses for multiple injections - in fact it is much easier to set things up this way. FOXO4-DRI dissolves very readily in saline, so placing a single human dose into 0.5ml or 1ml is quite feasible. A 3ml vial can hold three doses for the treatment without issue.
One approach is to measure out FOXO4-DRI by weight using a suitable microscale...
Source: Fight Aging! - March 5, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Tropical Travel Trouble 002 Rabies
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 002
A 19 year old gap year student has returned from India to your emergency department reporting she was bitten by a monkey at a temple. A selfie gone wrong but it scored 1000+ likes on Facebook…
She is concerned because one of the Facebook comments suggested she may have rabies! A quick Google search suggested 60,000 people a year DIE from rabies.
Should she be worried? Should you be worried?
Questions
Q1. What other questions should yo...
Source: Life in the Fast Lane - February 27, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine rabies Source Type: blogs
Fight Aging! Newsletter, February 19th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - February 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
