The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials
AbstractFlexible sigmoidoscopy (FS), which is less invasive, resource intensive and costly than colonoscopy, is among the recommended screening options for colorectal cancer (CRC). Four large randomized trials consistently reported statistically significant, albeit modest effects of screening by FS on CRC incidence. However, their effect estimates included cancers that were already prevalent at recruitment and could not have been prevented by screening. We performed a re-analysis and meta-analysis of two of the trials (including the largest one) to estimate reduction of truly incident cases by a single FS offered between 5...
Source: European Journal of Epidemiology - April 20, 2024 Category: Epidemiology Source Type: research
Validation of a Tool-Based Visual Anorectal Examination Advanced Simulator for the Early Detection of Colorectal Cancer
This study aims to establish the initial face, content, and construct validity of a tool-based visual anorectal examination advanced simulator model for proctoscopy and rigid sigmoidoscopy. This innovative, highly realistic simulated environment aims to enhance the training of healthcare professionals and improve the efficiency of detecting and diagnosing distal colorectal disease.PMID:38592245 | DOI:10.3390/jcm13051423 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Niamh Grayson Reza Haghighi Osgouei Renke Huang Paris Tekkis Fernando Bello Christos Kontovounisios Source Type: research
Validation of a Tool-Based Visual Anorectal Examination Advanced Simulator for the Early Detection of Colorectal Cancer
This study aims to establish the initial face, content, and construct validity of a tool-based visual anorectal examination advanced simulator model for proctoscopy and rigid sigmoidoscopy. This innovative, highly realistic simulated environment aims to enhance the training of healthcare professionals and improve the efficiency of detecting and diagnosing distal colorectal disease.PMID:38592245 | PMC:PMC10932247 | DOI:10.3390/jcm13051423 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Niamh Grayson Reza Haghighi Osgouei Renke Huang Paris Tekkis Fernando Bello Christos Kontovounisios Source Type: research
Effectiveness of sigmoidoscopy or colonoscopy screening on colorectal cancer incidence and mortality: a systematic review and meta-analysis of randomized controlled trial
CONCLUSION: This meta-analysis of randomized controlled trials underscores the effectiveness of colonoscopy and, notably, sigmoidoscopy in reducing colorectal cancer incidence and mortality among average-risk populations. In comparison to fecal immunochemical testing, both colonoscopy and sigmoidoscopy did not significantly impact colorectal cancer incidence and mortality in this population.SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023460007.PMID:38549924 | PMC:PMC10972922 | DOI:10.3389/fonc.2024.1364923 (Source: Cancer Control)
Source: Cancer Control - March 29, 2024 Category: Cancer & Oncology Authors: Chunyang Han Fan Wu Jian Xu Source Type: research
Management of an undetectable Diverticular Bleed: A Case Report and Literature review
Key Clinical MessageDiverticular bleeding is the most common cause of lower gastrointestinal bleeding and accounts for 20.8% –41.6% of cases in the Western world. Management involves initial resuscitation followed by diagnostic assessment. Colonoscopy is the investigation of choice as it localizes the bleed and has the potential to effectively deliver therapeutic interventions. Other diagnostic modalities include flexib le sigmoidoscopy, a tagged red blood cell scan, or angiography. In cases where the bleeding source cannot be identified, intraoperative enteroscopy has emerged as a valuable tool for investigating obscure...
Source: Clinical Case Reports - March 22, 2024 Category: General Medicine Authors: Zubir S. Rentiya,
Lokeshwar Raaju Addi Palle,
Sanni Emmanuel,
Heeya Shah,
Abiodun Adegbite,
Carlo Kristian Chu Carredo,
Ronald Mauricio Blanco Montecino,
Ummul Z. Asfeen,
Akbar Hussain,
Ogbonnaya Akuma,
Aadil Mahmood Khan,
Anasonye Emmanuel Tags: CASE REPORT Source Type: research
Effectiveness of sigmoidoscopy or colonoscopy screening on colorectal cancer incidence and mortality: a systematic review and meta-analysis of randomized controlled trial
ConclusionThis meta-analysis of randomized controlled trials underscores the effectiveness of colonoscopy and, notably, sigmoidoscopy in reducing colorectal cancer incidence and mortality among average-risk populations. In comparison to fecal immunochemical testing, both colonoscopy and sigmoidoscopy did not significantly impact colorectal cancer incidence and mortality in this population.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023460007. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 14, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1110: Screening Implications for Distribution of Colorectal Cancer Subsite by Age and Role of Flexible Sigmoidoscopy
Conclusions: 58% of CRC arises in locations visible by flexible sigmoidoscopy. Flexible sigmoidoscopy should be considered as a viable option for CRC screening, particularly in younger patients unwilling or unable to undergo colonoscopy. (Source: Cancers)
Source: Cancers - March 10, 2024 Category: Cancer & Oncology Authors: Gloria Lin David M. Hein Po-Hong Liu Amit G. Singal Nina N. Sanford Tags: Article Source Type: research
Cytomegalovirus Colitis in a Patient with Severe Treatment Refractory Ulcerative Colitis
CONCLUSIONS: Despite our patient having multiple risk factors for developing CMV colitis, upadacitinib may have played a role when considering its known impact on the herpes family of viruses. CMV colitis should be evaluated for in any patient who presents with worsening symptoms without evidence of other infection or response to increase in therapy.PMID:38444641 | PMC:PMC10914341 | DOI:10.1093/crocol/otae014 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Michelle M Bao Juliana M Kennedy Michael T Dolinger David Dunkin Joanne Lai Marla C Dubinsky Source Type: research
Cytomegalovirus Colitis in a Patient with Severe Treatment Refractory Ulcerative Colitis
CONCLUSIONS: Despite our patient having multiple risk factors for developing CMV colitis, upadacitinib may have played a role when considering its known impact on the herpes family of viruses. CMV colitis should be evaluated for in any patient who presents with worsening symptoms without evidence of other infection or response to increase in therapy.PMID:38444641 | PMC:PMC10914341 | DOI:10.1093/crocol/otae014 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Michelle M Bao Juliana M Kennedy Michael T Dolinger David Dunkin Joanne Lai Marla C Dubinsky Source Type: research
Risk factors and management of iatrogenic colorectal perforation in diagnostic colonoscopy: a single-center cohort study
CONCLUSIONS: Additional precautions are required to prevent perforation in elderly patients, hospital settings, low BMI, sedated patients, or by a doctor with slight familiarity with endoscopies (but still insufficient experience). Endoscopic treatment should be actively considered if diagnosis is prompt, abdominal pain absent, and especially the rectal perforation is present.PMID:38380637 | DOI:10.1080/00365521.2024.2316766 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 21, 2024 Category: Gastroenterology Authors: Aryoung Kim Heejung Kim Eun Ran Kim Ji Eun Kim Sung Noh Hong Dong Kyung Chang Young-Ho Kim Source Type: research
Clinical profile of 1208 newly diagnosed colorectal cancer patients in Tamil Nadu —A multi-centric survey
ConclusionsA majority of patients with newly diagnosed CRC in Tamil Nadu belonged to the lower socioeconomic classes. About 60% had CRCs located within the reach of the flexible sigmoidoscope. Two-thirds of the patients exceeded stage II disease at presentation.Trial registrationNot applicableGraphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 19, 2024 Category: Gastroenterology Source Type: research
