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Therapy: Immunotherapy
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Total 29681 results found since Jan 2013.
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research
Myelin oligodendrocyte glycoprotein antibody and N-methyl-d-aspartate receptor antibody overlapping syndrome: insights from the recent case reports
Clin Exp Immunol. 2023 Sep 19:uxad109. doi: 10.1093/cei/uxad109. Online ahead of print.ABSTRACTThe overlapping of two or more types of neural autoantibodies in one patient has increasingly been documented in recent years. The coexistence of myelin oligodendrocyte glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) antibodies is most common, which leads to a unique condition known as the MOG antibody and NMDAR antibody overlapping syndrome (MNOS). Here, we have reviewed the pathogenesis, clinical manifestations, paraclinical features, and treatment of MNOS. Forty-nine patients with MNOS were included in this study....
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Bing-Qing Du Qi-Lun Lai Er-Chuang Li Meng-Ting Cai Gao-Li Fang Chun-Hong Shen Yin-Xi Zhang Mei-Ping Ding Source Type: research
Spermidine - an old molecule with a new age-defying immune function
Trends Cell Biol. 2023 Sep 16:S0962-8924(23)00166-6. doi: 10.1016/j.tcb.2023.08.002. Online ahead of print.ABSTRACTPolyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is prod...
Source: Trends in Cell Biology - September 18, 2023 Category: Cytology Authors: Kenji Chamoto Baihao Zhang Masaki Tajima Tasuku Honjo Sidonia Fagarasan Source Type: research
Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study
CONCLUSION: Chemotherapy combined with or without targeted therapy remained dominated third-line choice and showed favorable efficacy compared with anti-angiogenic monotherapy. With the application of more types and quantities of effective drugs, patients would achieve better survival.PMID:37720594 | PMC:PMC10501067 | DOI:10.1177/20406223231197311
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Ting Deng Jingjing Duan Ming Bai Le Zhang Hongli Li Rui Liu Tao Ning Shaohua Ge Xia Wang Yuchong Yang Zhi Ji Feixue Wang Yi Ba Source Type: research
Navigating the challenges of invasive pulmonary aspergillosis in lung cancer treatment: a propensity score study
CONCLUSIONS: IPA tended to be diagnosed more frequently in patients receiving chemotherapy or immune checkpoint inhibitors. Patients diagnosed with IPA are associated with shorter survival. Larger cohort studies are needed to verify the observations.PMID:37720497 | PMC:PMC10503299 | DOI:10.1177/17588359231198454
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Chin-Wei Kuo Chien-Yu Lin Sheng-Huan Wei Yun-Tse Chou Chian-Wei Chen Jeng-Shiuan Tsai Po-Lan Su Chien-Chung Lin Source Type: research
Controversies in the surgical management of esophageal adenocarcinoma
J Gastrointest Oncol. 2023 Aug 31;14(4):1919-1926. doi: 10.21037/jgo-22-713. Epub 2023 Aug 30.ABSTRACTThe incidence of esophageal adenocarcinoma (EAC) has risen dramatically over the last decade. Over this same period, our understanding and treatments have been revolutionized. Just over a decade ago, the majority of patients with locally advanced esophageal cancer went directly to surgery and our overall survival was bleak. Our current strategy for locally advanced esophageal adenocarcinoma is a multi-disciplinary approach. This approach consists of chemotherapy plus or minus radiation followed by surgical resection follow...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Stephanie G Worrell Daniela Molena Source Type: research
Efficient TNBC immunotherapy by dual reprogramming tumor-infiltrating dendritic cells and tumor-associated macrophages with stimulus-responsive miR155 nanocomplexes
In this study, pH/ROS-responsive microRNA-155 (miR155) nanocomplexes (MiR@PCPmP NPs) were developed to reprogram TIDCs and TAMs for efficient TNBC immunotherapy. This nanoplatform was based on a pH/ROS cleavable copolymer of poly(ethylene glycol)-carboxydimethyl maleate-poly(ethyleneimine)-peroxalate ester-poly(ε-caprolactone) grafted with mannose moieties (PEG-CDM-PEI[Man]-ox-PCL) which self-assembled with miRNA to form nanocomplexes. In the tumor microenvironment, the nanocomplexes showed selective cellular uptake by TIDCs and TAMs through PEG detachment and mannose exposure, followed by efficient endosomal escape, cyto...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenghui Jing Yanfeng Li Jinxiao Song Xinlong Zang Source Type: research
The negative effect of concomitant medications on immunotherapy in non-small cell lung cancer: An umbrella review
CONCLUSIONS: The concurrent usage of PPIs or steroids adversely affects the survival of patients with NSCLC receiving immunotherapy. Future investigations are required to ascertain whether these adverse effects are primarily attributed to the comorbidities or the concurrent medications.PMID:37722262 | DOI:10.1016/j.intimp.2023.110919
Source: International Immunopharmacology - September 18, 2023 Category: Allergy & Immunology Authors: Jixin Chen Shuqi Chen Huiyan Luo Shunqin Long Xiaobing Yang Wenfeng He Wanyin Wu Sumei Wang Source Type: research
Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy
CONCLUSION: The CRISPR/Cas9 exon skipping approach could be used in adoptive cell immunotherapies to change PD-1 expression patterns and overcome exhaustion.PMID:37718766 | DOI:10.22074/cellj.2023.1999548.1269
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Zeinab Yousefi-Najafabadi Zohreh Mehmandoostli Yazdan Asgari Saeed Kaboli Reza Falak Gholam Ali Kardar Source Type: research
A collagen-binding SIRP αFc fusion protein for targeted cancer immunotherapy
Int Immunopharmacol. 2023 Sep 16;124(Pt B):110951. doi: 10.1016/j.intimp.2023.110951. Online ahead of print.ABSTRACTCollagen is abundant but exposed in tumor due to the abnormal tumor blood vessels, thus is considered as a tumor-specific target. The A3 domain of von Willebrand factor (vWF A3) is a kind of collagen-binding domain (CBD) which could bind collagen specifically. Previously we reported a chemosynthetic CBD-SIRPαFc conjugate, which could block CD47 and derived tumor-targeting ability by CBD. CBD-SIRPαFc conjugate represented improved anti-tumor efficacy with increased MHC II+ M1 macrophages, but the uncertain c...
Source: International Immunopharmacology - September 18, 2023 Category: Allergy & Immunology Authors: Jiayang Liu Tongyang Xu Danjie Pan Jiajun Fan Yuan Fu Xiting Huang Weili Zhao Xiaochun Dong Shaohui Zhang Kudelaidi Kuerban Xuan Huang Songna Wang Huaning Chen Yunpeng He Yi Zhun Zhu Congjun Wang Li Ye Source Type: research
Prevalence of Enteric Infections in Patients on Immune Checkpoint Inhibitors and Impact on Management and Outcomes
CONCLUSIONS: GI infections in ICI-treated patients presenting with diarrhea are linked to more severe but self-limited clinical presentations and may be optimally treated with observation and supportive care alone. Routine and timely stool pathogen testing may help avert unnecessary empiric immunosuppression for suspected irEC, which has been linked to blunted antitumor responses and numerous adverse effects.PMID:37721546 | DOI:10.1093/oncolo/oyad226
Source: The Oncologist - September 18, 2023 Category: Cancer & Oncology Authors: Patrick T Magahis Deepika Satish Ngolela Esther Babady Mini Kamboj Michael A Postow Monika Laszkowska David M Faleck Source Type: research
PD-1-Targeted Immunotherapy: The Ligand Matters
J Immunol. 2023 Oct 1;211(7):1065-1066. doi: 10.4049/jimmunol.2300239.NO ABSTRACTPMID:37722094 | DOI:10.4049/jimmunol.2300239
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Andreas Wieland Mark P Rubinstein Zihai Li Source Type: research
Pan-Cancer Analysis of Oncogenic Role of RAD54L and Experimental Validation in Hepatocellular Carcinoma
CONCLUSION: RAD54L exhibits robust expression in both pan-cancer and HCC, exerting a significant influence on the proliferation and migration of HCC cells. These findings highlight its potential as a promising biomarker for pan-cancer and a prospective target for immunotherapy.PMID:37719938 | PMC:PMC10503553 | DOI:10.2147/JIR.S426558
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yongzhen Zhou Chenjie Qiu Qingsheng Fu Tao Li Xudong Zhang Chunfu Zhu Xihu Qin Baoqiang Wu Source Type: research
Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer
CONCLUSION: Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.PMID:37719086 | PMC:PMC10505079 | DOI:10.1155/2023/2473075
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Qianqian Wang Chunxaing Feng Yuchun Chen Tianming Peng Yong Li Kunlin Wu Xiaoyong Pu Hanzhong Chen Jiumin Liu Source Type: research
Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma
CONCLUSION: In our study, the IMDC was confirmed to be a prognostic factor for MM. The IMDC groups were similar, except for the favorable RCC and MM groups. Different metastatic sites were prognostic, similar to the IMDC risk group in the MM group.PMID:37718781 | DOI:10.3233/CBM-230159
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Ismail Beyp ınar Y ıldız Sözel Arif Hakan Önder Source Type: research
