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Therapy: Immunotherapy
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Total 29681 results found since Jan 2013.
Molecular subtypes and prognostic models for predicting prognosis of lung adenocarcinoma based on miRNA-related genes
CONCLUSION: Such miRNA-associated target gene characterization could be useful for prognostic prediction and contribute to therapeutic decision-making in LUAD.PMID:37711127 | DOI:10.2174/0929867331666230914151943
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Yuxi Wei Wei Zhong Yalan Bi Xiaoyan Liu Qing Zhou Jia Liu Mengzhao Wang Hong Zhang Minjiang Chen Source Type: research
Selecting Triple Negative Breast Cancer Patients for Immunotherapy
Surg Oncol Clin N Am. 2023 Oct;32(4):733-745. doi: 10.1016/j.soc.2023.05.005. Epub 2023 Jun 5.ABSTRACTThe approval of preoperative immunotherapy combined with chemotherapy is a practice-changing advance for patients with early-stage triple-negative breast cancer. The optimal patient selection requires careful attention to staging and balancing potential risks with expected benefits, particularly as it relates to immune-related adverse events.PMID:37714640 | DOI:10.1016/j.soc.2023.05.005
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Elizabeth A Mittendorf Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
Selecting Triple Negative Breast Cancer Patients for Immunotherapy
Surg Oncol Clin N Am. 2023 Oct;32(4):733-745. doi: 10.1016/j.soc.2023.05.005. Epub 2023 Jun 5.ABSTRACTThe approval of preoperative immunotherapy combined with chemotherapy is a practice-changing advance for patients with early-stage triple-negative breast cancer. The optimal patient selection requires careful attention to staging and balancing potential risks with expected benefits, particularly as it relates to immune-related adverse events.PMID:37714640 | DOI:10.1016/j.soc.2023.05.005
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Elizabeth A Mittendorf Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
Selecting Triple Negative Breast Cancer Patients for Immunotherapy
Surg Oncol Clin N Am. 2023 Oct;32(4):733-745. doi: 10.1016/j.soc.2023.05.005. Epub 2023 Jun 5.ABSTRACTThe approval of preoperative immunotherapy combined with chemotherapy is a practice-changing advance for patients with early-stage triple-negative breast cancer. The optimal patient selection requires careful attention to staging and balancing potential risks with expected benefits, particularly as it relates to immune-related adverse events.PMID:37714640 | DOI:10.1016/j.soc.2023.05.005
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Elizabeth A Mittendorf Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
Molecular subtypes and prognostic models for predicting prognosis of lung adenocarcinoma based on miRNA-related genes
CONCLUSION: Such miRNA-associated target gene characterization could be useful for prognostic prediction and contribute to therapeutic decision-making in LUAD.PMID:37711127 | DOI:10.2174/0929867331666230914151943
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Yuxi Wei Wei Zhong Yalan Bi Xiaoyan Liu Qing Zhou Jia Liu Mengzhao Wang Hong Zhang Minjiang Chen Source Type: research
Plasma extracellular vesicle long RNAs predict response to neoadjuvant immunotherapy and survival in patients with non-small cell lung cancer
Pharmacol Res. 2023 Sep 12:106921. doi: 10.1016/j.phrs.2023.106921. Online ahead of print.ABSTRACTNeoadjuvant immunotherapy has brought new hope for patients with non-small cell lung cancer (NSCLC). However, limited by the lack of clinically feasible markers, it is still difficult to select NSCLC patients who respond well and to predict patients' clinical outcomes before the treatment. Before the treatment, we isolated plasma extracellular vesicles (EVs) from three cohorts (discovery, training and validation) of 78 NSCLC patients treated with neoadjuvant immunotherapy. To identify differentially-expressed EV long RNAs (exL...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Wei Guo Bolun Zhou Liang Zhao Qilin Huai Fengwei Tan Qi Xue Fang Lv Shugeng Gao Jie He Source Type: research
Diffuse large B-cell lymphoma involving the central nervous system: biologic rationale for targeted therapy
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2021.278613. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma curable even in advanced stages. DLBCL involving the central nervous system (CNS) is more difficult to cure and fewer treatment options exist. Primary CNS lymphoma (PCNSL) refers to aggressive lymphomas confined to the CNS, and are almost always DLBCL. Standard approaches for PCNSL use high-dose methotrexate based combinations as induction therapy and younger patients often receive dose-intensive consolidation. However, dose-intensive therapies are not suitable ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Mark Roschewski Daniel J Hodson Source Type: research
Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research
Clin Genet. 2023 Sep 14. doi: 10.1111/cge.14424. Online ahead of print.ABSTRACTCancer, one of the leading causes of death, usually commences and progresses as a result of a series of gene mutations and dysregulation of expression. With the development of clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene-editing technology, it is possible to edit and then decode the functions of cancer-related gene mutations, markedly advance the research of biological mechanisms and treatment of cancer. This review summarizes the mechanism and development of CRISPR/Cas9 gene-editing technology in recent years and descri...
Source: Clinical Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Li Ning Jiahui Xi Yin Zi Min Chen Qingjian Zou Xiaoqing Zhou Chengcheng Tang Source Type: research
Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer
This study suggests an emerging strategy based on a combination of EZH2 inhibitor and immunotherapy based on PD-1 inhibition.PMID:37708707 | DOI:10.1016/j.intimp.2023.110918
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Mengmeng Lv Sheng Guo Xinyu Zhang Yan Zou Qiang Chen Chongyi Zang Shuo Huang Yuhan Hu Yanling Wang Qianqing Wang Jiateng Zhong Source Type: research
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
CONCLUSION: Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.PMID:37710179 | DOI:10.1186/s12575-023-00217-y
Source: Biological Procedures Online - September 14, 2023 Category: Molecular Biology Authors: Min Wu Shihao Wu Yuetong Chen Liangchao Sun Jundong Zhou Source Type: research
Fatty acid metabolism-related genes as a novel module biomarker for kidney renal clear cell carcinoma: Bioinformatics modeling with experimental verification
CONCLUSIONS: In this study, a novel risk score model and a module biomarker based on FAM-related genes were screened for KIRC prognosis. More clinical carcinogenic validations will be performed for future translational applications of the findings.PMID:37708719 | DOI:10.1016/j.tranon.2023.101774
Source: Translational Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Zongming Jia Zhenyu Fu Ying Kong Chengyu Wang Bin Zhou Yuxin Lin Yuhua Huang Source Type: research
