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Therapy: Immunotherapy
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Total 29681 results found since Jan 2013.
Applications of tissue-specific and cancer-selective gene promoters for cancer diagnosis and therapy
Adv Cancer Res. 2023;160:253-315. doi: 10.1016/bs.acr.2023.03.005. Epub 2023 Apr 20.ABSTRACTCurrent treatment of solid tumors with standard of care chemotherapies, radiation therapy and/or immunotherapies are often limited by severe adverse toxic effects, resulting in a narrow therapeutic index. Cancer gene therapy represents a targeted approach that in principle could significantly reduce undesirable side effects in normal tissues while significantly inhibiting tumor growth and progression. To be effective, this strategy requires a clear understanding of the molecular biology of cancer development and evolution and develo...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Amit Kumar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Applications of tissue-specific and cancer-selective gene promoters for cancer diagnosis and therapy
Adv Cancer Res. 2023;160:253-315. doi: 10.1016/bs.acr.2023.03.005. Epub 2023 Apr 20.ABSTRACTCurrent treatment of solid tumors with standard of care chemotherapies, radiation therapy and/or immunotherapies are often limited by severe adverse toxic effects, resulting in a narrow therapeutic index. Cancer gene therapy represents a targeted approach that in principle could significantly reduce undesirable side effects in normal tissues while significantly inhibiting tumor growth and progression. To be effective, this strategy requires a clear understanding of the molecular biology of cancer development and evolution and develo...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Amit Kumar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
This study reviews the latest research progress on TLS detection and quantification, proposes new directions for TLS assessment, and addresses issues for the quantitative application of TLSs in the clinic.PMID:37701955 | PMC:PMC10500099 | DOI:10.1631/jzus.B2200605
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Man Yang Yurou Che Kezhen Li Zengyi Fang Simin Li Mei Wang Yiyao Zhang Zhu Xu Liping Luo Chuan Wu Xin Lai Weidong Wang Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Activation and differentiation of cognate T cells by a dextran-based antigen-presenting system for cancer immunotherapy
This article is protected by copyright. All rights reserved.PMID:37698527 | DOI:10.1002/eji.202350528
Source: European Journal of Immunology - September 12, 2023 Category: Allergy & Immunology Authors: Dhrubajyoti Mahata Debangshu Mukherjee Debarati Biswas Shyam Basak Aditya Jyoti Basak Imlilong Jamir Nidhi Pandey Huma Khatoon Dibyendu Samanta Amit Basak Gayatri Mukherjee Source Type: research
Integrated clustering signature of genomic heterogeneity, stemness and tumor microenvironment predicts glioma prognosis and immunotherapy response
CONCLUSIONS: This study identified risk hub genes and established a risk model by analyzing the genomic heterogeneity, stemness, and immune microenvironment of glioma. Our findings will facilitate the diagnosis and prediction of glioma prognosis and may lead to potential treatment strategies for glioma.PMID:37698534 | DOI:10.18632/aging.205018
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Yangyang Wu Meng Mao Lin-Jian Wang Source Type: research
Prognostic and immunological roles of IL18RAP in human cancers
In this study, based on bioinformatics analysis, we discovered that IL18RAP is related to the human tumor microenvironment and promotes various immune cells infiltration. Additionally, the multiple immunofluorescence staining revealed that with the increased expression of IL18RAP, the number of infiltrated M1 macrophages increased. This finding was confirmed by coculture migration analysis using three human cancer cell lines (MDA-MB-231, U251, and HepG2) with IL18RAP knockdown. We discovered a positive link between IL18RAP and the majority of immunostimulators, immunoinhibitors, major histocompatibility complex (MHC) molec...
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Wu Chen Tianbao Song Fan Zou Yuqi Xia Ji Xing Weimin Yu Ting Rao Xiangjun Zhou Chenglong Li Jinzhuo Ning Sheng Zhao Yuan Ruan Fan Cheng Source Type: research
Treatment strategy for de novo metastatic nasopharyngeal carcinoma: a literature review
CONCLUSIONS: Given the diversity of metastatic NPC, a multimodality approach incorporating chemotherapy, immunotherapy, locoregional radiation and ablative treatment to metastatic sites has been shown to improve overall control. Further research is needed to determine the efficacy and optimal duration of maintenance therapy.PMID:37699604 | DOI:10.21037/cco-23-32
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Qin Liu Jishi Li Wai Tong Ng Anne W M Lee Source Type: research
Nivolumab as maintenance therapy following platinum-based chemotherapy in EGFR-mutant lung cancer patients after tyrosine kinase inhibitor failure: A single-arm, open-label, phase 2 trial
CONCLUSION: Nivolumab maintenance following platinum-based chemotherapy did not show clinical benefits after EGFR-TKI failure in patients with EGFR-mutant NSCLC.PMID:37699785 | DOI:10.1111/1759-7714.15083
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Jiwon Kim Chang-Min Choi Wonjun Ji Jae Cheol Lee Source Type: research
Re-routing the GPS directing immunotherapy in endometrial cancer
Clin Cancer Res. 2023 Sep 12. doi: 10.1158/1078-0432.CCR-23-1953. Online ahead of print.ABSTRACTMMR status alone is insufficient to guide the use of PD-(L)1 monotherapy in endometrial cancer patients. Additional biomarkers, including TMB and CPS score may help to identify patients with pMMR tumors with a high probability of benefit from PD-(L)1 monotherapy, and those with dMMR tumors who might require combination strategies.PMID:37698948 | DOI:10.1158/1078-0432.CCR-23-1953
Source: Clinical Cancer Research - September 12, 2023 Category: Cancer & Oncology Authors: Rhea Jangra Neesha C Dhani Source Type: research
A novel immunogenic cell death-related genes signature for predicting prognosis, immune landscape and immunotherapy effect in hepatocellular carcinoma
CONCLUSION: The ICD score exhibits a high degree of reliability for predicting prognosis and may provide valuable guidance for the selection of immunotherapy for HCC patients. This novel scoring system enables the estimation of clinical immunotherapy response for HCC patients, offering new opportunities for personalized immunotherapy.PMID:37698679 | DOI:10.1007/s00432-023-05370-1
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Guangming Xu Yifan Jiang Yu Li Jiangzhen Ge Xiaofeng Xu Diyu Chen Jian Wu Source Type: research
Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma
CONCLUSIONS: Seven MiAg-related genes were identified to be significantly associated with the prognosis of patients diagnosed with LUAD. Moreover, the identified MiAg DEGs might affect the immunotherapy strategy of patients with LUAD.PMID:37698683 | DOI:10.1007/s00432-023-05390-x
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Xiangzhi Meng Weijian Song Boxuan Zhou Mei Liang Yushun Gao Source Type: research
