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Total 109398 results found since Jan 2013.
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Importance of aspartate 4 in the Mg < sup > 2+ < /sup > dependent regulation of Leishmania major PAS domain-containing phosphoglycerate kinase
Biochim Biophys Acta Proteins Proteom. 2023 Sep 17:140964. doi: 10.1016/j.bbapap.2023.140964. Online ahead of print.ABSTRACTMagnesium is an important divalent cation for the regulation of catalytic activity. Recently, we have described that the Mg2+ binding through the PAS domain inhibits the phosphoglycerate kinase (PGK) activity in PAS domain-containing PGK from Leishmania major (LmPAS-PGK) at neutral pH 7.5, but PGK activity is derepressed at acidic pH 5.5. The acidic residue within the PAS domain of LmPAS-PGK is expected to bind the cofactor Mg2+ ion at neutral pH, but which specific acidic residue(s) is/are responsibl...
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Gaurab Chowdhury Saroj Biswas Yuthika Dholey Puja Panja Sumit Das Subrata Adak Source Type: research
Estrogen sulfotransferase SULT1E1 expression levels and regulated factors in malignant tumours
Protein Pept Lett. 2023 Sep 15. doi: 10.2174/0929866530666230915103418. Online ahead of print.ABSTRACTEstrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignan...
Source: Protein and Peptide Letters - September 19, 2023 Category: Biochemistry Authors: Rui Wang Xia Li Yangyang Li Mengjie Zhao Lida Mi Weiwei Chen Jianxiang Song Source Type: research
Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)
Biosci Biotechnol Biochem. 2023 Sep 18:zbad135. doi: 10.1093/bbb/zbad135. Online ahead of print.ABSTRACTWe evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin (DCX)-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.PMID:37723613 | DOI:10.1093/bbb/zbad135
Source: Bioscience, Biotechnology, and Biochemistry - September 19, 2023 Category: Biochemistry Authors: Mitsuki Umino Mayumi Okuda Takeshi Ohkubo Tsutomu Fujii Kiminori Matsubara Source Type: research
Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 18. doi: 10.3724/abbs.2023148. Online ahead of print.NO ABSTRACTPMID:37723875 | DOI:10.3724/abbs.2023148
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells
This study aimed to figure out how microRNA (miR)-411-3p's impacts on methotrexate (MTX)'s cellular uptake and cytotoxicity in acute lymphoblastic leukaemia (ALL) CEM-C1 cells by targeting Yin-yang 1 (YY1). miR-411-3p and YY1 were detected by RT-qPCR or Western blot. Intracellular MTX concentration was measured by enzyme-linked immunosorbent assay. Cell viability and apoptosis were evaluated by CCK-8, clonal formation assay, and flow cytometry. Verification of miR-411-3p and YY1's targeting link was manifested. It came out that miR-411-3p mimic or si-YY1 elevated intracellular MTX, MTX-induced cytotoxicity and apoptosis ra...
Source: Acta Biochim Pol - September 19, 2023 Category: Biochemistry Authors: HuiJing Sun ShuGuang Zhou ZhouSheng Yang MingYu Meng Yan Dai XinYe Li XiaoYu Chen Source Type: research
Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells
This study illustrates the effectiveness of TurboID in mESCs. Importantly, we found that application of both SILAC and LF methods in combination allowed us to analyze the TurboID proteomics data in an unbiased, stringent and yet comprehensive manner.PMID:37725837 | DOI:10.1016/j.bbrc.2023.09.017
Source: Biochemical and Biophysical Research communications - September 19, 2023 Category: Biochemistry Authors: Qianqian He Siu Kwan Sze Kai Soon Ng Cheng-Gee Koh Source Type: research
Distinctive Arbutin-Containing Markers: Chemotaxonomic Significance and Insights Into the Evolution of Proteaceae Phytochemistry
Chem Biodivers. 2023 Sep 19:e202301112. doi: 10.1002/cbdv.202301112. Online ahead of print.ABSTRACTNatural products isolation studies of eight endemic Tasmanian Proteaceae species - Agastachys odorata, Persoonia juniperina, Hakea megadenia, Hakea epiglottis, Orites diversifolius, Orites acicularis,Orites revolutus, and Telopea truncata - and three endemic Australian Proteaceae species Banksia serrata, Banksia praemorsa, and Banksia marginata were undertaken.Two previously unreported glycoside-derived natural products were identified, in addition to four other tremendously rare arbutin esters. The results of this study prov...
Source: Chemistry and Biodiversity - September 19, 2023 Category: Biochemistry Authors: Alex C Bissember Samuel D Zarfos Bianca J Deans Curtis C Ho Gregory J Jordan Jason A Smith Source Type: research
Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration
Biomacromolecules. 2023 Sep 19. doi: 10.1021/acs.biomac.3c00803. Online ahead of print.ABSTRACTDeveloping a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distri...
Source: Biomacromolecules - September 19, 2023 Category: Biochemistry Authors: Yangrui Du Yangjing Bai Shiying Lang Dandan Xing Li Ma Kaijun Li Jinyu Peng Xinyun Li Gongyan Liu Source Type: research
Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 18. doi: 10.3724/abbs.2023148. Online ahead of print.NO ABSTRACTPMID:37723875 | DOI:10.3724/abbs.2023148
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer-Opportunities for Drug Repurposing
Appl Biochem Biotechnol. 2023 Sep 18. doi: 10.1007/s12010-023-04595-7. Online ahead of print.ABSTRACTGlobally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma. One of the most vital aspects for proper diagnosis, prognosis, and adequate therapy is the precise classification of non-small cell lung cancer based on biomarke...
Source: Applied Biochemistry and Biotechnology - September 18, 2023 Category: Biochemistry Authors: Rajdeep Kaur P K Suresh Source Type: research
Exploring the Synthetic and Antioxidant Potential of 1,2-Disubstituted Benzimidazoles using Et3NHHSO4 Ionic Liquid Catalyst
Chem Biodivers. 2023 Sep 17:e202301159. doi: 10.1002/cbdv.202301159. Online ahead of print.ABSTRACTAn [Et3NH][HSO4] ionic-liquid catalyzed, intermolecular C-N bond formation for 1,2-disubstituted benzimidazole synthesis was achieved by the reaction of OPD and substituted aldehydes at ambient reaction conditions. Operational simplicity, use of easily available substrate and reagents, good yield in short reaction time, simple work-up, and column chromatographic free synthesis are remarkable features of this new protocol. The applicability of [Et3NH][HSO4] ionic-liquid as a green and inexpensive catalyst with good recyclabili...
Source: Chemistry and Biodiversity - September 18, 2023 Category: Biochemistry Authors: Nusrat Sahiba Pankaj Teli Priyadarshi Meena Shikha Agarwal Source Type: research
Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications
Biomacromolecules. 2023 Sep 17. doi: 10.1021/acs.biomac.3c00765. Online ahead of print.ABSTRACTPolysaccharides are carbohydrate polymers that are major components of plants, animals, and microorganisms, with unique properties. Biological hydrogels are polymeric networks that imbibe and retain large amounts of water and are the major components of living organisms. The mechanical properties of hydrogels are critical for their functionality and applications. Since synthetic polymeric double-network (DN) hydrogels possess unique network structures with high and tunable mechanical properties, many natural functional polysaccha...
Source: Biomacromolecules - September 18, 2023 Category: Biochemistry Authors: Pengguang Wang Qingyu Liao Hongbin Zhang Source Type: research
