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Specialty: Biochemistry
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Total 109398 results found since Jan 2013.
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
Histone mutations in cancer
Biochem Soc Trans. 2023 Sep 18:BST20210567. doi: 10.1042/BST20210567. Online ahead of print.ABSTRACTGenes encoding histone proteins are recurrently mutated in tumor samples, and these mutations may impact nucleosome stability, histone post-translational modification, or chromatin dynamics. The prevalence of histone mutations across diverse cancer types suggest that normal chromatin structure is a barrier to tumorigenesis. Oncohistone mutations disrupt chromatin structure and gene regulatory mechanisms, resulting in aberrant gene expression and the development of cancer phenotypes. Examples of oncohistones include the histo...
Source: Biochemical Society Transactions - September 18, 2023 Category: Biochemistry Authors: Kimberly N Espinoza Pereira Jixiu Shan Jonathan D Licht Richard L Bennett Source Type: research
Insights into the function of cytoglobin
Biochem Soc Trans. 2023 Sep 18:BST20230081. doi: 10.1042/BST20230081. Online ahead of print.ABSTRACTSince its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publications have examined different aspects of cytoglobin structure, redox chemistry and potential roles in cell signalling pathways. This research is wide ranging, but common themes have emerged throughout the research. This review examine...
Source: Biochemical Society Transactions - September 18, 2023 Category: Biochemistry Authors: Brandon J Reeder Source Type: research
Comprehensive review on single and dual modification of starch: Methods, properties and applications
Int J Biol Macromol. 2023 Sep 16;253(Pt 3):126952. doi: 10.1016/j.ijbiomac.2023.126952. Online ahead of print.ABSTRACTStarch is a natural, renewable, affordable, and easily available polymer used as gelling agents, thickeners, binders, and potential raw materials in various food products. Due to these techno-functional properties of starch, food and non-food industries are showing interest in developing starch-based food products such as films, hydrogels, starch nanoparticles, and many more. However, the application of native starch is limited due to its shortcomings. To overcome these problems, modification of starch is n...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Bharati Kumari Nandan Sit Source Type: research
Biomass-based indole derived fluorescence sensor composited with cellulose paper: Detection of picric acid in food and environment samples
Int J Biol Macromol. 2023 Sep 16:126963. doi: 10.1016/j.ijbiomac.2023.126963. Online ahead of print.ABSTRACTPicric acid (PA) is highly water-soluble, the fact makes it stand out as the most hazardous environment pollutant. Therefore, accurate determination of PA is of great significance for human health and environmental protection. Herein, a novel indole-based fluorescent sensor (H1) with good water solubility and fluorescence stability was reported. H1 exhibited 'turn-off' fluorescence response for PA with fast reaction rate (<30 s), unique specificity and excellent selectivity and high sensitivity (limit of detection...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Yingying Zhang Xiaoci Cui Xin Wang Xiuyuan Feng Weixia Cheng Ranhua Xiong Chaobo Huang Source Type: research
The emerging functions of mini zinc finger (MIF) microproteins in seed plants: A minireview
Biochimie. 2023 Sep 16:S0300-9084(23)00243-2. doi: 10.1016/j.biochi.2023.09.016. Online ahead of print.ABSTRACTMini zinc fingers constitute a class of microproteins that appeared early in evolution and expanded in seeds plants. In this review, the phylogenetic history, the functions and the mode of action of MIFs in plants are reported and discussed. It appears that mini zinc finger microproteins play an important role in the control of plant development. They are involved in the control of cell division and expansion and in the switch between the determinate/indeterminate state of the meristems. They are involved in the r...
Source: Biochimie - September 18, 2023 Category: Biochemistry Authors: Marie Rose Ndella Thiaw Pascal Gantet Source Type: research
Corrigendum to "pH evaluation in the digestive tract of the pygmy octopus, Paroctopus digueti" Comparative Biochemistry and Physiology, Part B 269 (2024) 110881
Comp Biochem Physiol B Biochem Mol Biol. 2023 Sep 16;269:110897. doi: 10.1016/j.cbpb.2023.110897. Online ahead of print.NO ABSTRACTPMID:37722231 | DOI:10.1016/j.cbpb.2023.110897
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - September 18, 2023 Category: Biochemistry Authors: N Perales-Garc ía D Tovar-Ram írez M G Mart ínez-Morales B P Ceballos-V ázquez D A Corona-Rojas M A Salcedo-Meza A Garrido-Mora F Vega-Villasante H Nolasco-Soria Source Type: research
Single-molecule analysis of osmolyte-mediated nanomechanical unfolding behavior of a protein domain
Int J Biol Macromol. 2023 Sep 15:126849. doi: 10.1016/j.ijbiomac.2023.126849. Online ahead of print.ABSTRACTThe small organic molecules, known as osmolytes being ubiquitously present in different cell types, affect protein folding, stability and aggregation. However, it is unknown how the osmolytes affect the nanomechanical unfolding behavior of protein domain. Here, we show the osmolyte-dependent mechanical unfolding properties of protein titin immunoglobulin-27 (I27) domain using an atomic force microscopy (AFM)-based single-molecule force spectroscopy. We found that amines and methylamines improved the mechanical stabil...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Manish Bajaj Mohd Muddassir Bumjoon Choi Priyanka Singh Jong Bum Park Surjeet Singh Manisha Yadav Rajesh Kumar Kilho Eom Deepak Sharma Source Type: research
A novel multifunctional chitosan-gelatin/carboxymethyl cellulose-alginate bilayer hydrogel containing human placenta extract for accelerating full-thickness wound healing
This study presents a multifunctional bi-layer hydrogel incorporating HPE for accelerating full-thickness wound healing through sustained HPE release, inhibition of bacteria invasion, and promotion of cell proliferation. The upper layer of the scaffold, known as the dressing layer, is composed of carboxymethyl cellulose and sodium alginate, serving as a supportive layer for cell proliferation. The under layer, referred to as the regenerative layer, is composed of chitosan and gelatin, providing an extracellular matrix-like, porous, moist, and antibacterial environment for cell growth. The scaffold was optimized to replicat...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Saeed Seifi Amir Shamloo Sayed Navid Tavoosi Aram Almasi-Jaf Hossein Shaygani Mohammad Reza Sayah Source Type: research
Activities of cellulose acetate and microcrystalline cellulose on the thermal and morphomechanical performances of a biobased hybrid composite made polybutylene succinate
Int J Biol Macromol. 2023 Sep 15:126918. doi: 10.1016/j.ijbiomac.2023.126918. Online ahead of print.ABSTRACTMicrocrystalline cellulose (MCC-30 wt%) was extruded with a blend of polybutylene succinate (PBS) and cellulose acetate (CADS=2.5-20 wt%) to produce two grades of binary (PBS/CA, PBS/MCC) and ternary (PBS/CA/MCC) specimens by injection into a mold previously thermostated at 22 °C and 78 °C. The structure-property relationships of neat PBS (n-PBS) and PBS-based blends were investigated by Fourier transform infrared (FTIR) spectroscopy, diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, scanning ele...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Thomas Sango Ahmed Koubaa Mohamed Ragoubi Martin Claude Ngueho Yemele Nathalie Leblanc Source Type: research
Chiral resolution of ( ±)-flurbiprofen using molecularly imprinted hydrazidine-modified cellulose microparticles
Int J Biol Macromol. 2023 Sep 15:126928. doi: 10.1016/j.ijbiomac.2023.126928. Online ahead of print.ABSTRACTFlurbiprofen (FP) is one of the non-steroidal anti-inflammatory drugs (NSAIDs) commonly used to treat arthritic conditions. FP has two enantiomers: S-FP and R-FP. S-FP has potent anti-inflammatory effects, while R-FP has nearly no such effects. Herein, molecularly imprinted microparticles produced from hydrazidine-cellulose (CHD) biopolymer for the preferential uptake of S-FP and chiral resolution of (±)-FP were developed. First, cyanoethylcellulose (CECN) was synthesized, and the -CN units were transformed into hyd...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Huda S AlSalem M Monier May Abdullah Abomuti Rua B Alnoman Hussam Y Alharbi Majed S Aljohani Soha T Al-Goul Eslam B Elkaeed Imen Zghab Amira L Shafik Source Type: research
Catalytic efficiency and thermal stability promotion of the cassava linamarase with multiple mutations for better cyanogenic glycoside degradation
In this study, the catalytic activity and thermal stability of enzymes were screened before investigating the degradation efficiency of cyanogenic glycosides with a cassava linamarase mutant K263P-T53F-S366R-V335C-F339C (CASmut) -controlled technique. The CASmut was obtained with the optimum temperature of 45 °C, which was improved by 10 °C. The specific activity of CASmut was 85.1 ± 4.6 U/mg, which was 2.02 times higher than that of the wild type. Molecular dynamics simulation analysis and flexible docking showed there were more hydrogen bonding interactions at the pocket, and the aliphatic glycoside of the linamarin w...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Yongheng Zhong Ye Li Qi Chen Shengyang Ji Minhao Xu Yuqi Liu Xiaodan Wu Shimin Li Kaimian Li Baiyi Lu Source Type: research
Influence of pH and ionic strength on the physicochemical and structural properties of soybean β-conglycinin subunits in aqueous dispersions
In this study, soybean β-conglycinin and its subunit fractions αα' and β were dispersed in solutions with different pH values (3.7, 7.6, and 9.0) at low (5 mM NaCl) and high (400 mM NaCl) ionic strengths, respectively. The solubility, rheology, particle size, zeta potential, microstructure, secondary structure, and tertiary structure of the different dispersions were analyzed using a range of analytical methods. The β-conglycinin, αα'- and β-subunits aggregated near the isoelectric point (pH 3.7). Increasing the ionic strength led to the assembly of more homogeneous units. An increase in ionic strength at pH 7.6 an...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Qian Ju Jieru Wang Hualu Zhou Dingkui Qin Xiaoyan Hu David Julian McClements Guangzhong Luan Source Type: research
Tissue and subcellular localization of CycD2 and KRPs are dissimilarly distributed by glucose and sucrose during early maize germination
Acta Histochem. 2023 Sep 15;125(7):152092. doi: 10.1016/j.acthis.2023.152092. Online ahead of print.ABSTRACTIn maize, immunoprecipitation assays have shown that CycD2;2 interacts with KRPs. However, evidence on CycD2;2 or KRPs localization and their possible interaction in specific tissues is lacking and its physiological consequence is still unknown. This work explores the spatiotemporal presence of CyclinD2s and KRPs, cell cycle regulators, during maize seed germination (18 and 36 h) after soaking on glucose or sucrose (120 mM). CyclinD2s are positive actors driving proliferation; KRPs are inhibitors of the main kinase c...
Source: Acta Histochemica - September 17, 2023 Category: Biochemistry Authors: Diana I Romero-S ánchez Sonia V ázquez-Santana Rafael A Alonso-Alvarez Jorge M V ázquez-Ramos Aurora Lara-N úñez Source Type: research
HSAFM-MIREBA - Methodology for Inferring REsolution in biological applications
Anal Biochem. 2023 Sep 15:115320. doi: 10.1016/j.ab.2023.115320. Online ahead of print.ABSTRACTDue to a lack of requirement for any direct labelling of the target molecule, high speed atomic force microscopy (HS-AFM) is a potentially powerful procedure for the assessment of biological processes involving macromolecules. When the sample is static the AFM device can be purposefully setup to recover high-resolution information about the feature in question. However, when the feature to be studied moves an appreciable amount during the course of the measurement, the obtained image will be blurred. Encountering such blurred obs...
Source: Analytical Biochemistry - September 17, 2023 Category: Biochemistry Authors: Damien Hall Source Type: research
