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Specialty: Biochemistry
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Total 109398 results found since Jan 2013.
miRNA contributes to neuropathic pains
Int J Biol Macromol. 2023 Sep 18:126893. doi: 10.1016/j.ijbiomac.2023.126893. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a kind of chronic pain caused by direct injury to the peripheral or central nervous system (CNS). microRNAs (miRNAs) are small noncoding RNAs that mostly interact with the 3 untranslated region of messenger RNAs (mRNAs) to regulate the expression of multiple genes. NP is characterized by changes in the expression of receptors and mediators, and there is evidence that miRNAs may contribute to some of these alterations. In this review, we aimed to fully comprehend the connection between NP and ...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Reyhaneh Vali Ali Azadi Ashkan Tizno Tahereh Farkhondeh Fariborz Samini Saeed Samarghandian Source Type: research
Microencapsulation of bioactive compound extracts using maltodextrin and gum arabic by spray and freeze-drying techniques
Int J Biol Macromol. 2023 Sep 18:126969. doi: 10.1016/j.ijbiomac.2023.126969. Online ahead of print.ABSTRACTMicroencapsulation techniques establish a protective barrier around a sensitive compound, reducing vulnerability to external influences and offering controlled release. This work evaluates microencapsulation of Brazilian seed known as pink pepper (Schinus terebinthifolius) extract incorporated with green propolis extract, (main propolis font from the South America native plant Baccharis dracunculifolia DC) to enhancement antioxidant activity through synergic interaction, comparing to the extracts individually. Four t...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Emanuele Joana Gbur Laureanti Thainnane Silva Paiva Luiz M ário de Matos Jorge Regina Maria Matos Jorge Source Type: research
Synthesis and antitumor activity of bagasse xylan derivatives modified by graft-esterification and cross-linking
Int J Biol Macromol. 2023 Sep 18:126867. doi: 10.1016/j.ijbiomac.2023.126867. Online ahead of print.ABSTRACTA crucial aspect in achieving sustainable development of biomass materials is the modification of renewable polysaccharides to create various high-value functional materials. In this paper, bagasse xylan (BX) was used as a raw material to introduce benzyl methacrylate (BMA) through graft copolymerization reaction to generate the intermediate product BX-g-BMA. Subsequently, the target product (CA-BX-g-BMA) was synthesized by catalytic esterification of BX-g-BMA with citric acid (CA) in AmimCl ionic liquid. Meanwhile, ...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Bin Zhao Heping Li Kexin Tian Yue Su Zhiming Zou Source Type: research
Construction and functional evaluation of oral long-acting insulin hydrogel microparticles based on physical and chemical double crosslinking
The objective of this study was to enhance the convenience and effectiveness of diabetes treatment by developing hydrogel microparticles as an oral insulin delivery system, aiming to reduce the necessity for frequent treatments. The hydrogel microparticles were prepared with polysaccharides through a combination of physical and chemical crosslinking method, they achieved good results in insulin loading efficiency (70 %), insulin release efficiency (98 %) and sustained release time (>20 h). The effective transmembrane transport was validated using an intestinal epithelial cell model, which demonstrated a continuous hypog...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: ShengQin Chen QingYa Miao Yang Liu Qiao Xiao YuKai Lin Yu Yang FengBiao Guo Source Type: research
Oil structuring from porous starch to powdered oil: Role of multi-scale structure in the oil adsorption and distribution
This study compared the role of multi-scale structure of porous starch (PS) prepared by normal and waxy maize starch in the oil adsorption. Waxy maize porous starch exhibited higher oil adsorption capacity (32.43 %-98.71 %) and more oil distributed on the surface of granules than normal maize porous starch, resulting from the more pores, larger specific surface area (1.01-1.53 m2/g), and pore size (8.45-9.32 nm). The enzymolysis time of native starch dominated oil distribution, leading to different granule adhesion and aggregation state. Pearson correlation analysis further showed oil adsorption capacity was negatively cor...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Miao Shao Songnan Li Sixin Huang Shahid Ahmed Junejo Yi Jiang Bin Zhang Qiang Huang Source Type: research
Characterization, health benefits, and food applications of enzymatic digestion- resistant dextrin: A review
Int J Biol Macromol. 2023 Sep 18:126970. doi: 10.1016/j.ijbiomac.2023.126970. Online ahead of print.ABSTRACTResistant dextrin or resistant maltodextrin (RD), a short-chain glucose polymer that is highly resistant to hydrolysis by human digestive enzymes, has shown broad developmental prospects in the food industry and has gained substantial attention owing to its lack of undesirable effects on the sensory features of food or the digestive system. However, comprehensive fundamental and application information on RD and how RD improves anti-diabetes and obesity have not yet been received. Therefore, the characterization, hea...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Fei Li Atif Muhmood Muhammad Akhter Xiang Gao Jie Sun Zubo Du Yuxi Wei Ting Zhang Yunlu Wei Source Type: research
Characterization and comparison of cardiomyocyte protection activities of non-starch polysaccharides from six ginseng root herbal medicines
Int J Biol Macromol. 2023 Sep 18;253(Pt 3):126994. doi: 10.1016/j.ijbiomac.2023.126994. Online ahead of print.ABSTRACTGinseng is rich of polysaccharides, however, the evidence supporting polysaccharides to distinguish various ginseng species is rarely reported. Focusing on six root ginseng (e.g., Panax ginseng-PG, P. quinquefolius-PQ, P. notoginseng-PN, red ginseng-RG, P. japonicus-PJ, and P. japonicus var. major-PJM), the contained non-starch polysaccharides (NPs) were structurally characterized and compared by both the chemical and biological evaluation. Holistic fingerprinting at three levels (the NPs and the acid hydro...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Jie Liu Xue Li Jing-Wen Guo Bo-Xue Chen He Sun Jia-Qi Huang Ying Hu Xiao-Yan Xu Mei-Ting Jiang Xiu-Mei Gao Wen-Zhi Yang Qi-Long Wang De-An Guo Source Type: research
Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism
In this study, manganese-doped albumin-gelatin composite nanogels (MAGN) were prepared and used to load berberine (Ber) for the treatment of gouty arthritis (GA). The nanodrug delivery system (Ber-MAGN) can target inflammatory joints due to the intrinsic high affinity of albumin for SPARC, which is overexpressed at the inflammatory site of GA. Characterization of the pharmaceutical properties in vitro showed that Ber-MAGN had good dispersion, and the particle size was 121 ± 10.7 nm. The sustained release effect significantly improved the bioavailability of berberine. In vitro and in vivo experimental results showed that B...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Junpeng Sun Xiaobang Liu Jiaqun Du Jinyu An Yingqiao Li Yu Hu Shuai Cheng Ying Xiong Yanan Yu He Tian Xifan Mei Chao Wu Source Type: research
Improved miscibility and toughness of biological poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/poly(lactic acid) blends via melt-blending-induced thermal degradation
This study aimed to improve the miscibility of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) and PLA by lowering their molecular weights via a melt-blending-induced thermal degradation during mechanical mixing to form m-P34HB/PLA blends. The molecular weight of the P34HB was significantly reduced after blending, thereby improving the miscibility of the blends, as evidenced by the shift of glass transition temperatures. Also, simulation based on Flory-Huggins theory demonstrated increased miscibility with decreasing molecular weight of the polymers. Moreover, the thermal gravimetric analysis revealed that the PLA pro...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Yit Thai Ong Ting-Min Chen Trong-Ming Don Source Type: research
Development of gallic acid-loaded ethylcellulose fibers as a potential wound dressing material
In this study, novel fibers were designed based on ethylcellulose (EC), loaded with different concentrations of gallic acid (GA) using the electrospinning technique, in order to investigate the potential of these materials as wound dressings. The chemical structure and morphology, along with the antimicrobial and biocompatibility tests of the EC_GA fibers were investigated. To observe the chemical interactions between the components, fourier transform infrared spectroscopy (FTIR) was used. The morphological analyzes were performed using scanning electron microscope (SEM). The uniaxial tensile test machine was used to obtai...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Alexa-Maria Croitoru Musa Ayran Eray Altan Yasin Karacelebi Songul Ulag Ali Sahin Mehmet Mucahit Guncu Burak Aksu Oguzhan Gunduz Bianca-Maria Tih ăuan Denisa Ficai Anton Ficai Source Type: research
Xanthan and gum acacia modified olive oil based nanoemulsion as a controlled delivery vehicle for topical formulations
In this study, olive oil nanoemulsion modified with xanthan gum and gum acacia was explored as a potential controlled topical delivery vehicle. Oil-in-water nanoemulsion formulated with optimized composition of olive oil, tween 80, and water was used as the drug carrier and further modified with gum. Effect of gum on nanoemulsion different physiochemical characteristics, stability, rheology, drug release and encapsulation efficiency were investigated. Results showed that developed nanoemulsion behaved as low viscosity Newtonian fluid and released 100 % drug within 6 h. Modification with xanthan and gum acacia had significa...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Khadijatul Kobra Siew Yee Wong Mohammad A Jafar Mazumder Xu Li M Tarik Arafat Source Type: research
Lavandula stoechas extract incorporated polylactic acid nanofibrous mats as an antibacterial and cytocompatible wound dressing
In this study, Lavandula stoechas extract (LSE) (0.25 %, 0.5 %, and 1%wt) incorporated-polylactic acid (PLA) nanofibrous mats were successfully produced and characterized. Microstructural analysis by SEM revealed that the fiber diameter changed with the increase in the amount of LSE. Also, the nanofibrous mats were evaluated for their in vitro antibacterial, cytotoxicity, and wound healing properties for their use as a wound dressing material. According to the results of the disc diffusion test, PLA nanofibrous mats containing LSE %1 showed 9.65 ± 0.46 and 7.37 ± 0.03 inhibition zone (mm) against E. coli and S. aureus, r...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Bet ül Mutlu Fatih Çiftçi Cem B ülent Üstündağ Rabia Çakır-Koç Source Type: research
Fabrication of versatile polyvinyl alcohol and carboxymethyl cellulose-based hydrogels for information hiding and flexible sensors: Heat-induced adjustable stiffness and transparency
Int J Biol Macromol. 2023 Sep 18:126950. doi: 10.1016/j.ijbiomac.2023.126950. Online ahead of print.ABSTRACTWith the growing demand for wearable electronics, designing biocompatible hydrogels that combine self-repairability, wide operating temperature and precise sensing ability offers a promising scheme. Herein, by interpenetrating naturally derived carboxymethyl cellulose (CMC) into a polyvinyl alcohol (PVA) gel matrix, a novel hydrogel is successfully developed via simple coordination with calcium chloride (CaCl2). The chelation of CMC and Ca2+ is applied as a second crosslinking mechanism to stabilize the hydrogel at r...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Yuanna Sun Fenling Shi Ruobing Tian Xiaoliang Zhao Qingshan Li Chen Song Ying Du Xinhai He Jun Fu Source Type: research
In-depth insight into the effects of tapioca or corn acetylated distarch phosphate on the gel properties and in vitro digestibility of kung-wan
This study aimed to investigate the effects of incorporating tapioca acetylated distarch phosphate (TADSP) or corn acetylated distarch phosphate (CADSP) on the gel properties and in vitro digestibility of Chinese-style meatballs known as kung-wan. The results showed that TADSP and CADSP significantly enhanced the textural properties of kung-wan in a dose-dependent manner (P < 0.05), as well as enhanced the rheological behavior of meat batters. TADSP resulted in a denser meat protein gel network compared to CADSP, primarily because the lower pasting temperature of TADSP made it gelatinize earlier and more completely duri...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Sumeng Wei Xue Liang Yining Xu Baohua Kong Xin Li Hongwei Zhang Qian Liu Hui Wang Source Type: research
Effects of carboxymethyl cellulose fiber formations with chitosan incorporation via coating and mixing processes
Int J Biol Macromol. 2023 Sep 18:126971. doi: 10.1016/j.ijbiomac.2023.126971. Online ahead of print.ABSTRACTTo date, the utilization of carboxymethyl cellulose (CMC) fibers are only restricted to weak mechanical application such as wound dressing. Physically, CMC has a weak mechanical strength due to the high hydrophilicity trait. However, this flaw was saved by the extensive number of reactive functional groups, allowing this macromolecule to form linkages with chitosan to ensure its versatility. This work successfully fabricated CMC-chitosan fiber via dissolution, crosslinking, dry-jet wet-spinning extrusion, and coagula...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Nur Fathihah Jafri Kushairi Mohd Salleh Nursyamimi Ahmad Ghazali Nyak Syazwani Nyak Mazlan Nurul Husna Ab Halim Sarani Zakaria Source Type: research
