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Infectious Disease: Parasitic Diseases
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Total 27724 results found since Jan 2013.
Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy
CONCLUSION: ABZ inhibits melanoma growth and metastasis. Moreover, ABZ synergized with PD-L1 blockade mediates tumor regression.PMID:37730912 | DOI:10.1007/s00432-023-05415-5
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Weinan Zhang Zhiqiang He Fucheng Liang Jie Gong Liuchang Tan Juan Yang Siji Song Luoyingzi Xie Yuangang Lu Source Type: research
Diethylcarbamazine elicits Ca < sup > 2+ < /sup > signals through TRP-2 channels that are potentiated by emodepside in < em > Brugia malayi < /em > muscles
Antimicrob Agents Chemother. 2023 Sep 20:e0041923. doi: 10.1128/aac.00419-23. Online ahead of print.ABSTRACTFilarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of l...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: Paul D E Williams Sudhanva S Kashyap Alan P Robertson Richard J Martin Source Type: research
Translational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state
RNA. 2023 Sep 20:rna.079625.123. doi: 10.1261/rna.079625.123. Online ahead of print.ABSTRACTTrypanosoma brucei occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping of the protein landscape of the parasite both to evade surveillance and face changing metabolic demands. In kinetoplastid protozoa, including T. brucei, post-transcriptional control mechanisms are the primary means of gene regulation, and these are often mediated by RNA-binding proteins. DRBD18 is a T. bruc...
Source: RNA - September 20, 2023 Category: Genetics & Stem Cells Authors: Martin Ciganda Jose Sotelo-Silveira Ashutosh P Dubey Parul Pandey Joseph T Smith Shichen Shen Jun Qu Pablo Smircich Laurie K Read Source Type: research
Nematodes as indicators of environmental changes in a river with different levels of anthropogenic impact
An Acad Bras Cienc. 2023 Sep 18;95(4):e20200307. doi: 10.1590/0001-3765202320200307. eCollection 2023.ABSTRACTConsidering that changes in the biodiversity of parasite communities can be used as indicators of ecosystem health, the aim of this study was to investigate the potential use of Geophagus brasiliensis parasites as bioindicators of environmental changes. We established three sample points in the Iguaçu River, each presenting different degrees of environmental impact. Out of the 69 G. brasiliensis specimens analyzed, 32 (46.3%) were parasitized by at least one parasite. We collected a total of 56 specimens of endopa...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Atsler Luana Lehun Gisele S C Duarte Ricardo M Takemoto Source Type: research
First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil
CONCLUSIONS: To the best of our knowledge, this is the first detection of LRV2 in the New World.PMID:37729273 | DOI:10.1590/0074-02760230071
Source: Memorias do Instituto Oswaldo Cruz - September 20, 2023 Category: Infectious Diseases Authors: Felipe Dutra R êgo Eduardo S érgio da Silva Valeriana Valadares Lopes Rafael Gon çalves Teixeira-Neto Vin ícius Silva Belo Ant ônio Augusto Fonseca Júnior Diego Andrade Pereira Heber Paulino Pena M árcia Dalastra Laurenti Gabriela V Ara újo V âni Source Type: research
Nematodes as indicators of environmental changes in a river with different levels of anthropogenic impact
An Acad Bras Cienc. 2023 Sep 18;95(4):e20200307. doi: 10.1590/0001-3765202320200307. eCollection 2023.ABSTRACTConsidering that changes in the biodiversity of parasite communities can be used as indicators of ecosystem health, the aim of this study was to investigate the potential use of Geophagus brasiliensis parasites as bioindicators of environmental changes. We established three sample points in the Iguaçu River, each presenting different degrees of environmental impact. Out of the 69 G. brasiliensis specimens analyzed, 32 (46.3%) were parasitized by at least one parasite. We collected a total of 56 specimens of endopa...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Atsler Luana Lehun Gisele S C Duarte Ricardo M Takemoto Source Type: research
Sampling for malaria molecular surveillance
We present examples for different use cases, including detecting emergence and spread of rare variants, establishing transmission sources and inferring changes in malaria transmission intensity. This review will potentially guide the collection of samples and data, serve as a starting point for further methodological innovation, and enhance utilization of MMS to support malaria elimination.PMID:37730525 | DOI:10.1016/j.pt.2023.08.007
Source: Trends in Parasitology - September 20, 2023 Category: Parasitology Authors: Alfredo Mayor Deus S Ishengoma Joshua L Proctor Robert Verity Source Type: research
The evolution of endoparasitism and complex life cycles in parasitic platyhelminths
Curr Biol. 2023 Sep 14:S0960-9822(23)01144-2. doi: 10.1016/j.cub.2023.08.064. Online ahead of print.ABSTRACTWithin flatworms, the vast majority of parasitism is innate to Neodermata, the most derived and diversified group of the phylum Platyhelminthes.1,2 The four major lineages of Neodermata maintain various combinations of life strategies.3 They include both externally (ecto-) and internally feeding (endo-) parasites. Some lineages complete their life cycles directly by infecting a single host, whereas others succeed only through serial infections of multiple hosts of various vertebrate and invertebrate groups. Food sour...
Source: Current Biology - September 20, 2023 Category: Biology Authors: Jan Brabec Eric D Salomaki Martin Kol ísko Tom áš Scholz Roman Kuchta Source Type: research
Diethylcarbamazine elicits Ca < sup > 2+ < /sup > signals through TRP-2 channels that are potentiated by emodepside in < em > Brugia malayi < /em > muscles
Antimicrob Agents Chemother. 2023 Sep 20:e0041923. doi: 10.1128/aac.00419-23. Online ahead of print.ABSTRACTFilarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of l...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: Paul D E Williams Sudhanva S Kashyap Alan P Robertson Richard J Martin Source Type: research
Sampling for malaria molecular surveillance
We present examples for different use cases, including detecting emergence and spread of rare variants, establishing transmission sources and inferring changes in malaria transmission intensity. This review will potentially guide the collection of samples and data, serve as a starting point for further methodological innovation, and enhance utilization of MMS to support malaria elimination.PMID:37730525 | DOI:10.1016/j.pt.2023.08.007
Source: Trends in Parasitology - September 20, 2023 Category: Parasitology Authors: Alfredo Mayor Deus S Ishengoma Joshua L Proctor Robert Verity Source Type: research
A Ruptured Cystic Echinococcosis in the Gallbladder and Intra/Extrahepatic Biliary Tract, Radiological and Surgical Imaging Findings
Turkiye Parazitol Derg. 2023 Sep 18;47(3):200-203. doi: 10.4274/tpd.galenos.2023.65265.ABSTRACTCystic echinococcosis is a common parasitic infestation that can still cause serious complications in endemic areas. Intrabiliary rupture is a well-defined complication, but rupture into the gallbladder is rare. The disease may present with cholecystitis and cholangitis. Clinicians and radiologists working in the emergency room will find the management of the disease much easier if they become familiar with the clinical and radiological findings of the cyst. In this article, a 28-year-old male admitted to the emergency department...
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Saim T ürkoğlu Abdurrahman Ekici Leyla Turgut Çoban İlyas Dündar Ozan Okyay Esra G ürbüz Source Type: research
The Parasites of Cats in T ürkiye
Turkiye Parazitol Derg. 2023 Sep 18;47(3):190-199. doi: 10.4274/tpd.galenos.2023.85698.ABSTRACTCats have an important and different place due to their close relationships with humans. Since most of the parasites they carry are zoonotic, it is important to detect them. According to the research, Dipylidium caninum, Joyeuxiella pasqualei, Toxocara spp., Toxascaris leonina, Giardia spp., Isospora spp., and Toxoplasma sp. were found to be higher in cats compared to other parasites. It has been determined that scabies and flea infestations are common as ectoparasites. This review aims to present the reported parasites and their...
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Öykü Barılı Tu ğçe Tuygun Elif Burcu Gen çay Topçu Şinasi Umur Source Type: research
Scientometric Evaluation of the Itch Mite, < em > Sarcoptes scabiei < /em > (Acari: Sarcoptidae): The Last Four Decades of Global Academic Output on Scabies
CONCLUSION: The majority of the studies were done in a given country while multicenter studies are very rare. It is recommended that more studies should be conducted on scabiosis in developing countries where the problem of scabies is the biggest.PMID:37724367 | DOI:10.4274/tpd.galenos.2023.51423
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Kosta Y Mumcuo ğlu Engin Şenel Ay şegül Taylan Özkan Source Type: research
