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Genetic Predictors of Ibrutinib-Related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia
CONCLUSIONS: Our findings suggest possible genetic determinants of ibrutinib-related CVSEs in CLL. If replicated in a larger study, pre-treatment pharmacogenetic testing for GATA4 and KCNQ1 polymorphisms may be a useful clinical tool for personalizing treatment selection for CLL and/or instituting early risk-mitigation strategies.PMID:37738027 | DOI:10.1158/1078-0432.CCR-23-0421
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Issam S Hamadeh Jai N Patel Ryan Jacobs Hang Zeng Jiaxian He Bei Hu Tamara Kay Moyo Amy Soni Steven Park Ed Copelan Belinda Avalos Alicia Hamilton Nury Steuerwald Nilanjan Ghosh Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Did COVID-19 Change the Availability and Use of Clean Energy for Cooking? Evidence From Ghana
This study provides insights that could be valuable in future understanding of the interactions between pandemic control measures and economic disruptions that may affect household energy choices for cooking.PMID:37736574 | PMC:PMC10510355 | DOI:10.1177/11786302231198854
Source: Environmental Health Insights - September 22, 2023 Category: Environmental Health Authors: Rebecca Kd Prah Darby Jack Theresa Tawiah Seidu Iddrisu Sulemana Watara Abubakari Mohammed Nuhu Mujtaba Richard Joshua Tetteh Stephaney Gyaase Mieks Twumasi Jason Saah Joseph Wilson Sheila Addo Daniel Pope Kwaku Poku Asante Elisa Puzzolo Source Type: research
Depletion of mTOR ameliorates CD < sub > 4 < /sub > < sup > + < /sup > T cell pyroptosis by promoting autophagy activity in septic mice
In this study, a septic mouse model was developed using cecal ligation and puncture (CLP) to explore the degree of pyroptosis and autophagy of CD4+ T cells. T-cell-specific mTOR/TSC1-knockout mice were used to investigate the role of mTOR pathway in the regulation of CD4+ T cell pyroptosis. Bafilomycin, a specific autophagy inhibitor, was used to verify the regulatory effect of autophagy on pyroptosis in septic mice. We observed aggravated pyroptosis in CD4+ T cells in CLP mice accompanied by impaired autophagy activity and an overactivated mTOR signaling pathway. Depletion of mTOR relieved autophagy deficiency and reduced...
Source: International Immunopharmacology - September 22, 2023 Category: Allergy & Immunology Authors: Ran Guo Guoyu Zhao Guangxu Bai Jianwei Chen Wen Han Na Cui Hao Wang Source Type: research
Meta-analysis of primary care delivered buprenorphine treatment retention outcomes
Conclusions: While we only investigate BT through primary care, our findings indicate retention rates are equivalent to the rates reported in the specialty care literature. More work is needed to examine factors that may impact primary care delivered BT specifically and differentiate participants that may benefit from care delivered in specialty over primary care as well as the converse.PMID:37737714 | DOI:10.1080/00952990.2023.2251653
Source: The American Journal of Drug and Alcohol Abuse - September 22, 2023 Category: Addiction Authors: Robert L Cooper Ryan D Edgerton Julia Watson Nicholas Conley William A Agee Derek M Wilus Samuel A MacMaster Lisa Bell Parul Patel Amruta Godbole Cynthia Bass-Thomas Aramandla Ramesh Mohammad Tabatabai Source Type: research
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
In this study, we examined the role of TRPML1 (TRP cation channel, mucolipin subfamily, member 1) in regulating the homeostasis of secretory lysosomes and their cross-talk with mitochondria in human NK cells. We found that genetic deletion of TRPML1, which localizes to lysosomes in NK cells, led to mitochondrial fragmentation with evidence of collapsed mitochondrial cristae. Consequently, TRPML1-/- NK92 (NK92ML1-/-) displayed loss of mitochondrial membrane potential, increased reactive oxygen species stress, reduced ATP production, and compromised respiratory capacity. Using sensitive organelle-specific probes, we observed...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Dennis Clement Edina K Szabo Silje Zandstra Krokeide Merete Thune Wiiger Marianna Vincenti Daniel Palacios Young-Tae Chang Christian Grimm Sandip Patel Harald Stenmark Andreas Brech Rakesh Kumar Majhi Karl-Johan Malmberg Source Type: research
Opioid Prescribing Habits of Emergency Department Providers in Response to an Educational Intervention
CONCLUSION: Overall, the educational intervention on the topic of opioid prescribing guidelines did not have the expected impact on amounts of opioids administered or prescribed during the study period. Total opioids utilized and opioids prescribed did not vary between the pre- and post-intervention groups overall, by subset diagnosis, or by provider. There was, however, an increase in utilization of non-opioid treatments that could be indicative of a partial response to the educational intervention. This study showed that long-term effects of education regarding recommended opioid utilization might be less effective than ...
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Tory Makela Source Type: research
Patients with fibromyalgia in Finnish healthcare center - one-year follow up
CONCLUSION: With these results, we cannot conclude that ÖMPSQ predicts the patient's severity of symptoms. On the contrary, we can conclude that antidepressants and/or psychological therapy might reduce fibromyalgia symptoms for depressed patients with fibromyalgia. Patients with fibromyalgia might benefit from clinical evaluation and modifications to the treatment plan if necessary.PMID:37738389 | DOI:10.1080/02813432.2023.2259960
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Tommi J ärvinen Aleksi Varinen Markku Sumanen Source Type: research
Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells
This article is protected by copyright. All rights reserved.PMID:37736882 | DOI:10.1002/eji.202250360
Source: European Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Daisuke Kondo Ruriko Suzuki Ayako Matsumura Hitomi Meguri Masahiko Tanaka Makoto Itakura Naohide Hirashima Source Type: research
Loss of αβ but not γδ T cells in chickens causes a severe phenotype
This article is protected by copyright. All rights reserved.PMID:37735713 | DOI:10.1002/eji.202350503
Source: European Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Theresa von Heyl Romina Klinger Dorothea Aumann Christian Zenner Mohanned Alhussien Antonina Schlickenrieder Kamila Lengyel Hanna-Kaisa Vikkula Teresa Mittermair Hicham Sid Benjamin Schusser Source Type: research
Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research
Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis
Stem Cell Res Ther. 2023 Sep 21;14(1):262. doi: 10.1186/s13287-023-03466-6.ABSTRACTThe loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. Laboratory studies have used in vitro testicular models and different 3-dimensional (3D) culture systems for preservation, proliferation and differentiation of spermatogonial stem cells (SSCs) in recent decades. The establishment of testis-like structures would facilitate the study of drug and toxicity screening, pathological mechanisms and in vitro differentiation of SSCs which resulted in possible treatmen...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Maryam Salem Farnaz Khadivi Parinaz Javanbakht Sina Mojaverrostami Mehdi Abbasi Narjes Feizollahi Yasaman Abbasi Ehsan Heidarian Farzane Rezaei Yazdi Source Type: research
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
CONCLUSIONS: In this study we report that an inherent enrichment of distinct GSCs pools underpin the functional inter-cluster variances displayed by GBM patients. We uncover two selectively represented novel functional biomarkers capable of discriminating GBM patients' stratification, survival and drug response, setting the stage for the determination of patient-tailored diagnostic and prognostic strategies and, mostly, for the design of appropriate, patient-selective treatment protocols.PMID:37735434 | DOI:10.1186/s13046-023-02811-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Alberto Visioli Nadia Trivieri Gandino Mencarelli Fabrizio Giani Massimiliano Copetti Orazio Palumbo Riccardo Pracella Maria Grazia Cariglia Chiara Barile Luigi Mischitelli Amata Amy Soriano Pietro Palumbo Federico Legnani Francesco DiMeco Leonardo Gorgog Source Type: research
Evaluation of treatment patterns, healthcare resource utilization and cost of illness for sickle cell disease in Ghana: a private medical insurance claims database study
CONCLUSION: In this retrospective private insurance claims database analysis, SCD imposes a significant healthcare burden, especially in patients with VOC. There is a need for reimbursed treatment options that could reduce the long-term burden associated with SCD and VOC.PMID:37735428 | DOI:10.1186/s12913-023-09984-6
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Kwaku Marfo Yvonne Dei-Adomakoh Catherine Segbefia Duah Dwomoh Adeline Edgal Nancy Ampah Badarinath Chickballapur Ramachandrachar Kumaresan Subramanyam Ashok Natarajan Olufolake Egbujo Kenneth I Ataga Source Type: research
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice
CONCLUSIONS: Our study highlights the beneficial effects of hUC-MSC treatment on PND and provides a justification to consider the potential use of hUC-MSCs in the perioperative period.PMID:37735415 | DOI:10.1186/s13287-023-03499-x
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Penghui Wei Min Jia Xiangyi Kong Wenyuan Lyu Hao Feng Xinyi Sun Jianjun Li Jian-Jun Yang Source Type: research
