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Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review
CONCLUSIONS: Although PHGS is a disease with a high worldwide prevalence, the lack of consensus about therapeutic management indicates gaps in existing evidence. Most of the proposed treatment consists in symptomatic drugs with empiric regimens which are ineffective for the viral replication. The main limit to realize randomized clinical trial is due to the rapid onset and remission of the disease. In fact, the diagnostic delay, estimated in 72 h, decreases the effectiveness of any antiviral drugs.CLINICAL RELEVANCE: Out of the five studies included in this systematic review, only one was able to provide some weak evidence...
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Noemi Coppola Tiziana Cantile Daniela Adamo Federica Canfora Stefania Baldares Francesco Riccitiello Gennaro Musella Michele Davide D Mignogna Stefania Leuci Source Type: research
The effect of herpes zoster vaccination on the occurrence of deaths due to dementia in England and Wales
CONCLUSIONS: Our findings indicate that HZ vaccination improved cognitive function at a fairly advanced stage of the dementia disease process because most individuals whose underlying cause of death was dementia during our nine-year follow-up period were likely already living with dementia at the start of the HZ vaccination program. By using a different population, type of data, and outcome than our prior study in Welsh electronic health record data, this analysis adds to the evidence base that HZ vaccination slows, or potentially even prevents, the natural history of dementia.PMID:37732219 | PMC:PMC10508823 | DOI:10.1101/2023.09.08.23295225
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Felix Michalik Min Xie Markus Eyting Simon He ß Seunghun Chung Pascal Geldsetzer Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Nutrition-associated health levels in persons with cancer: item response modelling based on the International Classification of Functioning, Disability and Health
CONCLUSIONS: The study constructed an evidence-based ICF scale for nutrition conditions in patients with cancer with 32-item and 2PLM for evaluating nutrition-associated health level in persons with cancer, including high validity and reliability.CLINICAL REHABILITATION IMPACT: The IRT model based on ICF provided a promising assessment tool to discriminate nutrition-associated health level of persons with cancer, and offered an auxiliary method for selecting rehabilitation intervention targets. This has the potential to lead to improved outcomes in cancer treatment and increased quality of life for cancer survivors.PMID:37...
Source: Methods of Information in Medicine - September 21, 2023 Category: Information Technology Authors: Jin-Jin Chen Zi-Yan Zhu Jia-Jia Bian Feng Lin Source Type: research
Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.PMID:37733239 | DOI:10.2807/1560-7917.ES.2023.28.38.2200938
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Tom áš Kliegr Ji ří Jarkovský Helena Ji řincová Jaroslav Kucha ř Tom áš Karel David Chud án Stanislav Voj íř Michal Zav řel Ond řej Šanca Ruth Tachezy Source Type: research
Surveillance of SARS-CoV-2 infection based on self-administered swabs, Denmark, May to July 2022: evaluation of a pilot study
ConclusionParticipants successfully performed self-swabs and answered symptom questionnaires. Also, WGS analysis of samples was possible. The system can support surveillance of respiratory pathogens and also holds potential as a diagnostic tool, easing access to test for at-risk groups, while also reducing the burden on healthcare system resources.PMID:37733236 | DOI:10.2807/1560-7917.ES.2023.28.38.2200907
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Kamille Fogh Tine Graakj ær Larsen Cyril Jean-Marie Martel Frederik Trier M øller Lasse Skafte Vestergaard Ramona Trebbien Anne-Marie Vangsted Tyra Grove Krause Source Type: research
Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders
Haematologica. 2023 Sep 21. doi: 10.3324/haematol.2023.283295. Online ahead of print.ABSTRACTStandard treatment for Langerhans Cell Histiocytosis (LCH) is chemotherapy, with high failure rates. Since MAP-kinase activating mutations are found in most cases, BRAF- and MEKinhibitors have been used successfully to treat patients with refractory or relapsed disease. However, data on long-term responses in children are limited and no data exist on their use as first-line therapy. We treated thirty-four patients (26 LCH, 2 Juvenile Xanthogranuloma, 2 Rosai-Dorfman Disease, 4 presumed single site-CNS histiocytosis) with either dab...
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Eily Cournoyer Justin Ferrell Susan Sharp Anish Ray Michael Jordan Christopher Dandoy Michael Grimley Somak Roy Robert Lorsbach Arnold C Merrow Adam Nelson Allison Bartlett Jennifer Picarsic Ashish Kumar Source Type: research
Idecabtagene vicleucel chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma with renal impairment
Haematologica. 2023 Sep 21. doi: 10.3324/haematol.2023.283940. Online ahead of print.ABSTRACTWe evaluated patients with relapsed multiple myeloma with renal impairment (RI treated with standard of care ide-cel, as outcomes with CAR-T therapy are unknown in this population. RI was defined as creatinine clearance (CrCl < 50 ml/min. CrCl of < 30 ml/min or dialysis dependence were defined as severe RI. The study cohort included 214 patients, 28 (13% patients with RI, including 11 patients severe RI (dialysis, n=1. Patients with RI were older, more likely to be female and had higher likelihood of having R-ISS stage 3 dise...
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Surbhi Sidana Lauren C Peres Hamza Hashmi Hitomi Hosoya Christopher Ferreri Jack Khouri Danai Dima Shebli Atrash Peter Voorhees Gary Simmons Douglas W Sborov Nilesh Kalariya Vanna Hovanky Sushma Bharadwaj David Miklos Charlotte Wagner Mehmet H Kocoglu Gur Source Type: research
Reply to "Comment on: A comparative study in type 2 von Willebrand disease patients using four different platelet-dependent von Willebrand factor assays"
Res Pract Thromb Haemost. 2023 Aug 25;7(6):102174. doi: 10.1016/j.rpth.2023.102174. eCollection 2023 Aug.NO ABSTRACTPMID:37732159 | PMC:PMC10507377 | DOI:10.1016/j.rpth.2023.102174
Source: Thrombosis and Haemostasis - September 21, 2023 Category: Hematology Authors: Paola Colpani Luciano Baronciani Giovanna Cozzi Maria Teresa Pagliari Eugenia Biguzzi Flora Peyvandi Source Type: research
Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells
CONCLUSION: ACE2 overexpression can inhibit HSC activation and promote cell apoptosis by regulating HSC autophagy through the AMPK/mTOR pathway, thereby alleviating liver fibrosis and hepatic sinusoidal remodeling.PMID:37732000 | PMC:PMC10507507 | DOI:10.3748/wjg.v29.i33.4975
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Ying Wu Ai-Hong Yin Jun-Tao Sun Wei-Hua Xu Chun-Qing Zhang Source Type: research
Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury
World J Gastroenterol. 2023 Sep 7;29(33):4927-4941. doi: 10.3748/wjg.v29.i33.4927.ABSTRACTHepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver transplantation, that may increase the postoperative morbidity, mortality, tumor progression, and metastasis. The underlying mechanisms have been extensively investigated in recent years. Among these, oxidative stress, inflammatory responses, immunoreactions, and cell death are the most studied. Non-coding RNAs (ncRNAs) are defined as the RNAs that do not encode proteins, but can regulate gene expressions. In recent years, ncRNAs have emerg...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Jia-Li Shao Li-Juan Wang Ji Xiao Jin-Feng Yang Source Type: research
Very early onset perinatal constipation: Can it be cow's milk protein allergy?
World J Gastroenterol. 2023 Sep 7;29(33):4920-4926. doi: 10.3748/wjg.v29.i33.4920.ABSTRACTDelayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung's disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow's milk protein allergy (CMPA) is often diagnosed in infa...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Rajalakshmy Arakoni Hebat Kamal Sam Xianjun Cheng Source Type: research
Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.ABSTRACTHepatitis due to hepatitis B virus (HBV) reactivation can be serious and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving chemotherapy, especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation. Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver. The expression of these silent genomes is controlled by the immune system. Suppression or ablation of immune cells, most imp...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Source Type: research
Direct oral anticoagulants for the treatment of splanchnic vein thrombosis: A state of art
World J Gastroenterol. 2023 Sep 7;29(33):4962-4974. doi: 10.3748/wjg.v29.i33.4962.ABSTRACTSplanchnic vein thrombosis (SVT) is a manifestation of venous thromboembolism in an unusual site. Portal, mesenteric, and splenic veins are the most common vessels involved in SVT which occurs mainly in patients with liver cirrhosis, although non-cirrhotic patients could be affected as well. Thrombosis of hepatic veins, also known as Budd-Chiari syndrome, is another manifestation of SVT. Prompt diagnosis and intervention are mandatory in order to increase the recalization rate and reduce the risk of thrombus progression and hypertensi...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Giovanni Monaco Luca Bucherini Bernardo Stefanini Fabio Piscaglia Francesco Giuseppe Foschi Luca Ielasi Source Type: research
The effects of cycling on walking outcomes in adults with stroke: a systematic review
CONCLUSION: Considerable heterogeneity was observed across cycling protocols with respect to intensity, frequency, exercise duration and protocol duration. However, none of the studies reported declines in walking outcomes and improvements were measured in the absence of task-specific gait training. Cycling interventions employing moderate- to high-intensity aerobic training and 24 sessions or more may be optimal in improving gait velocity and walking capacity.PMID:37732513 | DOI:10.1080/10749357.2023.2259167
Source: Topics in Stroke Rehabilitation - September 21, 2023 Category: Neurology Authors: Madeeha Khan Logan M Maag Mary Pat Harnegie Susan M Linder Source Type: research
