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Development in the Inhibition of Dengue Proteases as Drug Targets
CONCLUSION: Different classes of compounds have been reported against DENV, such as nitrogen-containing heterocycles (i.e., imidazole, pyridine, triazoles quinazolines, quinoline, and indole), oxygen-containing heterocycles (i.e., coumarins), and some are mixed heterocyclic compounds of S, N (thiazole, benzothiazine, and thiazolidinediones), and N, O (i.e., oxadiazole). There have been reports of computationally designed compounds to impede the molecular functions of specific structural and non-structural proteins as potential therapeutic targets. This review summarized the current progress in developing dengue protease in...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Muhammad Akram Shehryar Hameed Abbas Hassan Khalid Khan Source Type: research
Establishment and multicenter external validation of a risk prediction model for de novo intracranial aneurysms based on a systematic review and meta-analysis of 19 cohorts
CONCLUSIONS: This prediction model is a convenient and intuitive tool for identifying high-risk patients with de novo IAs. Reasonable use of the model can not only aid in clinical decision-making but also play a positive role in the prevention of aneurysmal subarachnoid hemorrhage to a certain extent.PMID:37724813 | DOI:10.3171/2023.7.JNS23749
Source: Journal of Neurosurgery - September 19, 2023 Category: Neurosurgery Authors: Jiahe Tan Rui Song Jun Su Hongyu Wu Wenqiao Fu Yinrui Ma Zhaohui He Source Type: research
Moral resilience in registered nurses: Cultural adaption and validation study
This study aimed to translate the Rushton Moral Resilience Scale (RMRS) into Chinese and evaluate the psychometric properties of the Chinese version of RMRS (Chi-RMRS).RESEARCH DESIGN: A methodological and descriptive research design.PARTICIPANTS AND RESEARCH CONTEXT: A convenience sample of 411 Chinese professional nurses was recruited through an online survey platform between February and March 2023.ETHICAL CONSIDERATIONS: This study was approved by the Research Ethics Committees of the University and hospitals involved.RESULTS: The RMRS was translated and culturally adapted into a Chinese version. Neither floor nor ceil...
Source: Nursing Ethics - September 19, 2023 Category: Nursing Authors: Xu Tian Qiaoling He Xiaoling Liu Xiuni Gan Mar ía F Jiménez Herrera Source Type: research
Characterization of photochemical losses of volatile organic compounds and their implications for ozone formation potential and source apportionment during summer in suburban Jinan, China
Environ Res. 2023 Sep 17;238(Pt 1):117158. doi: 10.1016/j.envres.2023.117158. Online ahead of print.ABSTRACTVolatile organic compounds (VOCs) undergo substantial photochemical losses during their transport from emission sources to receptor sites, resulting in serious implications for their source apportionment and ozone (O3) formation. Based on the continuous measurements of VOCs in suburban Jinan in August 2022, the effects of photochemical losses on VOC source contributions and O3 formation were evaluated in this study. The observed and initial concentrations of total VOCs (TVOC) were 12.0 ± 5.1 and 16.0 ± 7.4 ppbv, re...
Source: Environmental Research - September 19, 2023 Category: Environmental Health Authors: Zhenguo Liu Baolin Wang Chen Wang Yuchun Sun Chuanyong Zhu Lei Sun Na Yang Guolan Fan Xiaoyan Sun Zhiyong Xia Guang Pan Changtong Zhu Yichao Gai Xiaoyu Wang Yang Xiao Guihuan Yan Chongqing Xu Source Type: research
Alteromonas Aquimaris sp. nov., Isolated from Surface Seawater
Curr Microbiol. 2023 Sep 19;80(11):343. doi: 10.1007/s00284-023-03472-0.ABSTRACTA Gram-negative, aerobic, motile by flagellum, and rod-shaped bacterium, designated ASW11-7T, was isolated from coastal surface seawater sample collected from the Yellow Sea, PR China. Strain ASW11-7T grew optimally at 37℃, 4.0% (w/v) NaCl and pH 7.0. Phylogenetic analysis based on the 16S rRNA gene sequences revealed that strain ASW11-7T belongs to the genus Alteromonas and most closely related to Alteromonas ponticola MYP5T (99.6% similarity), followed by Alteromonas confluentis DSSK2-12T (98.2%), Alteromonas lipolytica JW12T (98.2%), and A...
Source: Current Microbiology - September 19, 2023 Category: Microbiology Authors: Qin Wang Xin-Yuan Hu Li-Ping Sun Hui-Jing Niu Cai-Xia Pei Yi Li Cheng-Qiang Xia Source Type: research
A large survey on COVID-19 vaccination in patients with Parkinson's disease and healthy population
CONCLUSIONS: The COVID-19 vaccination rate was remarkably lower in PD patients than healthy individuals in China. The approved vaccines have shown an acceptable safety profile. Our findings would offer a reference to guide future clinical decision-making of COVID-19 vaccination and improve the immunization management of PD patients.PMID:37726180 | DOI:10.1016/j.vaccine.2023.09.002
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Chao Han Zhen Zhen Zhao Piu Chan Fang Li Chun Ling Chi Xin Zhang Yan Zhao Jing Chen Jing Hong Ma Source Type: research
Women's experiences of primary dysmenorrhea symptoms: a systematic review of qualitative evidence and meta-aggregation
Women Health. 2023 Sep 14;63(8):658-668. doi: 10.1080/03630242.2023.2255289. Epub 2023 Sep 19.ABSTRACTPrimary dysmenorrhea (PD) has a significant impact on women's lives, especially among young women who miss school and work due to painful periods. Experiences and how women manage PD have been explored to some extent, but the evidence has not been systematically collated and reviewed to allow health professionals to better understand women's experiences of and perceptions about PD. Hence, we aim to synthesize the qualitative evidence related to women's experiences of PD and associated symptoms. For this purpose, seven data...
Source: Women and Health - September 19, 2023 Category: Primary Care Authors: Ana Moreno G ómez Ping Guo Ana Isabel de la Llave Rinc ón Nikolaos Efstathiou Source Type: research
China ’s Worst Capital Outflow in Years Spells More Yuan Pressure
China is witnessing the biggest flight of capital in years, creating concern for authorities as it worsens pressure on the beleaguered yuan. • None Debris Spotted in Search for Missing US F-35 Fighter Jet • None Vegas’ Newest Resort Is a $3.7 Billion Palace, 23 Years in the Making • None How Auto…#beleagueredyuan #nonedebrisspotted #trump #beijing #hongkong #garyng #natixissa #malaysia #edmundgoh
Source: Reuters: Health - September 19, 2023 Category: Consumer Health News Source Type: news
Publication retraction in spine surgery: a systematic review
ConclusionsThe retraction of publications has increased in recent years in spine surgery. Researchers consulting this body of literature should remain vigilant. Institutions and journals should collaborate to increase publication transparency and scientific integrity.
Source: European Spine Journal - September 19, 2023 Category: Orthopaedics Source Type: research
Neurological telerehabilitation in the COVID-19 era – current perspectives through a bibliometric analysis
ConclusionA greater interest in the subject was observed in China with greater relevance of journals and institutions focused on neurology. However, despite telerehabilitation being an effective alternative in the context of the pandemic, few studies have explored this modality.
Source: Frontiers in Neurology - September 19, 2023 Category: Neurology Source Type: research
Quality of evidence supporting the role of acupuncture for breast cancer-related lymphoedema: an overview of systematic reviews and meta-analyses
CONCLUSIONS: Acupuncture may be beneficial in improving BCRL. However, due to the identified limitations and conflicting findings, further more prescriptive and rigorous SRs/MAs are required to give strong evidence for final judgments.PMID:37721568 | DOI:10.1007/s00432-023-05419-1
Source: Clinical Breast Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Lei Wang Xueyuan Du Peng Hu Yaling Zhang Mingchao Yao Xiaoling Che Source Type: research
Normal values of left atrial size and strain analyzed by the dedicated speckle-tracking echocardiography in Chinese population
Kardiol Pol. 2023 Sep 18. doi: 10.33963/v.kp.97479. Online ahead of print.NO ABSTRACTPMID:37718581 | DOI:10.33963/v.kp.97479
Source: Polish Heart Journal - September 18, 2023 Category: Cardiology Authors: Lei Li Chunyuan You Jun Yang Junfei Shen Pingyang Zhang Source Type: research
Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals
CONCLUSION: CVAI, TyG-WC, TyG-WHtR and LAP were independently associated with the prevalence of CA. Specifically, CVAI may be the most appropriate predictor of CA in normal-weight individuals.PMID:37719743 | PMC:PMC10501451 | DOI:10.3389/fpubh.2023.1241523
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Zeyu Liu Bi Deng Qin Huang Ruxin Tu Fang Yu Jian Xia Jie Feng Source Type: research
The mechanism of Plantaginis Semen in the treatment of diabetic nephropathy based on network pharmacology and molecular docking technology
CONCLUSION: PS can have the treatment on DN through CASP3. Quercetin, as one of the nine active ingredients, can be bounded to CASP3 to inhibit apoptosis in DN. PS can also take action on DN probably through many pathways. The role of PS on DN through other pathways still needs to be further elaborated.PMID:37718520 | DOI:10.2174/1871530323666230915100355
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Linlin He Kai Shen Lei He Yuqing Chen Zhiyuan Tang Source Type: research
Quality of evidence supporting the role of acupuncture for breast cancer-related lymphoedema: an overview of systematic reviews and meta-analyses
CONCLUSIONS: Acupuncture may be beneficial in improving BCRL. However, due to the identified limitations and conflicting findings, further more prescriptive and rigorous SRs/MAs are required to give strong evidence for final judgments.PMID:37721568 | DOI:10.1007/s00432-023-05419-1
Source: Clinical Genitourinary Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Lei Wang Xueyuan Du Peng Hu Yaling Zhang Mingchao Yao Xiaoling Che Source Type: research
