• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Sexual and Gender Diversity in Pediatric Neurology: Why We Care
Sexual and gender diversity (SGD) – an inclusive term describing people who identify outside of heteronormative binary concepts of gender and sexuality – directly affects us in the pediatric neurology clinic. SGD identity can impact various neurological conditions, including headache, epilepsy, and functional neurological disord ers, all of which have been observed at higher rates in the SGD community.1-4 Gender-affirming hormone therapy can interact with medications commonly used to treat neurological conditions1,5,6 and may increase the risk for idiopathic intracranial hypertension7 and stroke.
Source: Pediatric Neurology - April 19, 2023 Category: Neurology Authors: Alison Christy, Jaclyn Martindale, Jennifer Hranilovich, Casey Orozco-Poore, Finley Kernan-Schloss, Chase T.M. Anderson, Jonathan Strober, Wendy Mitchell, Mackenzie P. Lerario Tags: Editorial Source Type: research

Diagnosis, Treatment, and Prevention of Stroke in Transgender Adults
AbstractPurpose of ReviewTo identify the current state of science on stroke in transgender adults and highlight gaps in need of further research. We will review current research on cerebrovascular risk and disease, hormone therapy, and stroke in transgender individuals. Finally, we will provide a framework for healthcare providers to prevent and reduce disparities through inclusive care practices.Recent FindingsTransgender people experience unique stroke risk factors, secondary to both psychosocial stress and health-related behaviors. These include higher rates of HIV, tobacco use, stimulant use, and hepatitis C. The use o...
Source: Current Treatment Options in Neurology - July 11, 2022 Category: Neurology Source Type: research

Sex and Gender Considerations in Episodic Migraine
AbstractPurpose of ReviewWe seek to update readers on recent advances in our understanding of sex and gender in episodic migraine with a two part series. In part 1, we examine migraine epidemiology in the context of sex and gender, differences in symptomatology, and the influence of sex hormones on migraine pathophysiology (including CGRP). In part 2, we focus on practical clinical considerations for sex and gender in episodic migraine by addressing menstrual migraine and the controversial topic of hormone-containing therapies. We make note of data applicable to gender minority populations, when available, and summarize kn...
Source: Current Pain and Headache Reports - June 9, 2022 Category: Neurology Source Type: research

Loss of Estrogen Efficacy Against Hippocampus Damage in Long-Term OVX Mice Is Related to the Reduction of Hippocampus Local Estrogen Production and Estrogen Receptor Degradation
AbstractPostmenopausal women experience a higher risk for neurodegenerative diseases, including cognitive impairment and ischemic stroke. Many preclinical studies have indicated that estrogen replacement therapy (ERT) may provide protective effects against these neurological diseases. However, the results of Women ’s Health Initiative (WHI) studies have led to the proposal of “critical period hypothesis,” which states that there is a precise window of opportunity for administering beneficial hormone therapy following menopause. However, the underlying molecular mechanisms require further characterizatio n. Here, we e...
Source: Molecular Neurobiology - June 14, 2020 Category: Neurology Source Type: research

Stroke Characteristics, Risk Factors, and Outcomes in Transgender Adults: A Case Series
Conclusions: Understanding unique vulnerabilities of the transgender community for cerebrovascular events is essential to provide culturally appropriate counseling for harm reduction.
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

In the Clinic-Stroke: Early Hormone Therapy Not Associated with Greater Stroke Risk in Postmenopausal Women
No abstract available
Source: Neurology Today - January 25, 2018 Category: Neurology Tags: Features Source Type: research

Risk of Stroke With Various Types of Menopausal Hormone Therapies Brief Report
Conclusions—In a national setting, we found an increased risk of stroke, based on ischemic stroke, with oral hormone therapies that was comparable to findings from randomized studies. We found no risk of stroke with transdermal application and a reduced risk with vaginal estrogen.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Ellen Lokkegaard, Lars Hougaard Nielsen, Niels Keiding Tags: Epidemiology, Risk Factors, Women, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study
Conclusions: Our results do not provide strong evidence for a protective association between postmenopausal HT use and AD or dementia, although we observed a reduced AD risk among those with long-term self-reported HT use.
Source: Neurology - March 12, 2017 Category: Neurology Authors: Imtiaz, B., Tuppurainen, M., Rikkonen, T., Kivipelto, M., Soininen, H., Kröger, H., Tolppanen, A.-M. Tags: Alzheimer's disease, Cohort studies ARTICLE Source Type: research

Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model.
CONCLUSION: We conclude that a combined steroid treatment inhibits ischemia-induced neuronal apoptosis through the regulation of intrinsic pathways. PMID: 27832728 [PubMed - as supplied by publisher]
Source: Neurological Research - November 13, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Postmenopausal Hormone Therapy and Risk of Stroke: Impact of the Route of Estrogen Administration and Type of Progestogen Clinical Sciences
Conclusions— Both route of estrogen administration and progestogens were important determinants of IS. Our findings suggest that transdermal estrogens might be the safest option for short-term hormone therapy use.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Canonico, M., Carcaillon, L., Plu-Bureau, G., Oger, E., Singh-Manoux, A., Tubert-Bitter, P., Elbaz, A., Scarabin, P.-Y. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Women Clinical Sciences Source Type: research

Reprint of: From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.
This article is part of a Special Issue entitled SI:50th Anniversary Issue. PMID: 27317847 [PubMed - as supplied by publisher]
Source: Brain Research - June 14, 2016 Category: Neurology Authors: Engler-Chiurazzi EB, Singh M, Simpkins JW Tags: Brain Res Source Type: research

Plasma uric acid concentrations and risk of ischaemic stroke in women
ConclusionsPlasma uric acid levels were not independently associated with increased risk of ischaemic stroke in this cohort of women. Whilst plasma uric acid was associated with stroke risk factors, it was not independently associated with stroke risk.
Source: European Journal of Neurology - March 31, 2016 Category: Neurology Authors: M. C. Jiménez, G. C. Curhan, H. K. Choi, J. P. Forman, K. M. Rexrode Tags: Original Article Source Type: research

Obesity, Oral Contraceptive Use, and Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that primarily affects young adults. A unique risk factor profile and plurality of presenting features make it an elusive diagnosis unless a high index of suspicion is maintained. It comprises approximately 0.5% to 1% of all strokes, and widespread availability of magnetic resonance imaging has made recognition easier. The International Study on Cerebral Vein and Dural Sinus Thrombosis is the largest prospective, multinational, observational study of patients with CVT to date, including 624 consecutive patients with symptomatic CVT at 89 centers between May ...
Source: JAMA Neurology - March 15, 2016 Category: Neurology Source Type: research

From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.
This article is part of a Special Issue entitled SI:50th Anniversary Issue. PMID: 26740397 [PubMed - as supplied by publisher]
Source: Brain Research - December 29, 2015 Category: Neurology Authors: Engler-Chiurazzi EB, Singh M, Simpkins JW Tags: Brain Res Source Type: research

Pulmonary Arteriovenous Malformation as a Cause of Embolic Stroke: Case Report and Review of the Literature
We describe an 82-year-old woman without history of respiratory or neurological diseases, who presented at our observation unit with acute onset of cerebral ischemia. Clinical, laboratory and radiological findings diagnosed a PAVM. Key Messages: Usually, endovascular procedures based on embolization or, alternatively, surgery represent the recommended treatment. However, both hormonal therapy and thrombolytic therapy can be used. In our patient, treatment with warfarin induced a remission of symptoms. This strategy should be tested in larger studies.Intervent Neurol 2014;3:27-30
Source: Interventional Neurology - November 10, 2014 Category: Neurology Source Type: research

Pages: 1  2