Obesity, Oral Contraceptive Use, and Cerebral Venous Thrombosis

Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that primarily affects young adults. A unique risk factor profile and plurality of presenting features make it an elusive diagnosis unless a high index of suspicion is maintained. It comprises approximately 0.5% to 1% of all strokes, and widespread availability of magnetic resonance imaging has made recognition easier. The International Study on Cerebral Vein and Dural Sinus Thrombosis is the largest prospective, multinational, observational study of patients with CVT to date, including 624 consecutive patients with symptomatic CVT at 89 centers between May 1998 and May 2001. Of these patients, 465 were women (74.5%), and they tended to be younger than men at diagnosis (median age, 34 vs 42 years). A total of 301 (65.0%) of these women had an identified sex-specific risk factor, such as oral contraceptive (OC) use, pregnancy, puerperium, or hormonal therapy. It was also observed that women with sex-specific risk factors who develop CVT tend to have better outcomes than women without sex-specific risk factors, which was thought to be owing to younger age and shorter onset to diagnosis period.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Publication date: Available online 31 March 2020Source: Neurophysiologie CliniqueAuthor(s): Karim Jamal, Stéphanie Leplaideur, Chloé Rousseau, Sébastien Cordillet, Annelise Moulinet Raillon, Simon Butet, Armel Cretual, Isabelle Bonan
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Authors: Ventura CG, Roque FL, Sousa IQ, Lobo RD, Luders C Abstract INTRODUCTION: Chronic hemodialysis (HD) patients are considered to be at high risk for infection. Here, we describe the clinical outcomes of chronic HD patients with influenza A (H1N1) infection and the strategies adopted to control an outbreak of influenza A in a dialysis unit. METHODS: Among a total of 62 chronic HD patients, H1N1 infection was identified in 12 (19.4%). Of the 32 staff members, four (12.5%) were found to be infected with the H1N1 virus. Outcomes included symptoms at presentation, comorbidities, occurrence of hypoxemia, hospit...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
This article explores the experiences of a primary care-based pilot clinic providing gender-affirming hormone therapy in Wellington, New Zealand. AIM To evaluate service users' and health professionals' experiences of a pilot clinic at Mauri Ora (Victoria University of Wellington's Student Health and Counselling Service) that provided gender-affirming hormones through primary care. METHODS In-depth interviews were conducted with four (out of six) service users and four health professionals about their perspectives on the clinic. Interviews were transcribed verbatim and analysed using thematic analysis. RESULTS Three themes...
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; &AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regio...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
​BY FREDDIE IRIZARRY-DELGADO; VAROON KAKAIYA; &AHMED RAZIUDDIN, MDAn 86-year-old African-American woman was brought to the ED by her daughter after two days of nutritional neglect, abdominal pain, and altered mental status. Her daughter said her mother felt lightheaded, appeared dehydrated, and vomited nonbilious watery fluid once. The patient had a history of diabetes mellitus type 2, DVT/PE, dementia, and early signs of parkinsonism.Her vital signs were remarkable only for tachypnea (24 bpm). Her troponin I was markedly elevated at 1.7 ng/mL. A D-dimer was ordered because of her history of unprovoked DVT/PE, and it...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
BackgroundPatients with immune thrombocytopenia (ITP) may be at increased risk of thromboembolism related to different causes, including the use of thrombopoietin receptor agonists and splenectomy. Patients with ITP who develop coronary artery disease (CAD) can be a further challenge given their risk of both thromboembolism and bleeding, which may significantly increase the risk of mortality and length of stay (LOS) compared to patients who do not have ITP. We aimed to study the impact of ITP in hospital outcomes of patients with CAD.MethodsWe utilized the National Inpatient Sample database from years 2009 - 2011. We selec...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology Source Type: research
Publication date: Available online 31 October 2015 Source:Gynécologie Obstétrique & Fertilité Author(s): M. Lobert, M. Pigeyre, H. Gronier, S. Catteau-Jonard, G. Robin La prévalence de l’obésité augmente massivement depuis plusieurs dizaines d’années dans les pays industrialisés. Les femmes obèses ont une activité sexuelle, non différente des femmes de poids normal, et bénéficieraient d’une couverture contraceptive moindre et d’un risque de grossesse non désirée plus élevé...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research
Abstract The prevalence of obesity is increasing massively over several decades in industrialized countries. Obese women are sexually active but they use fewer contraceptive methods and are at high risk of unintended pregnancy. In addition, obesity is an important risk factor for venous thromboembolism events and arterial thrombosis (myocardial infarction and ischemic stroke). All of these data are to be considered in choosing a contraceptive method for obese women. Except depot medroxyprogesterone acetate injection, the progestin-only contraceptives (progestin only pills and etonogestrel subdermal implant) and th...
Source: Gynecologie, Obstetrique et Fertilite - Category: OBGYN Authors: Tags: Gynecol Obstet Fertil Source Type: research
Women who take a newer version of birth control pills have a doubled risk of developing potentially fatal blood clots, according to a new study published in the British medical journal BMJ. Venous thromboembolism is a serious condition that encompasses both deep vein thrombosis -- when a person develops a blood clot in the legs -- and pulmonary embolism, in which the clot travels to the lungs and obstructs breathing. VTE is potentially fatal, and the study indicates that women who take combined oral contraceptives with newer progesterone formulations are two times more likely to develop it as opposed to women who take a ...
Source: Science - The Huffington Post - Category: Science Source Type: news
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