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Total 19 results found since Jan 2013.

Start, Stop, Continue? The Benefit of Overlapping Intravenous Thrombolysis and Mechanical Thrombectomy
ConclusionThe presented results support the approach of continuing and completing a  simultaneous administration of intravenous thrombolysis during mechanical thrombectomy procedures.
Source: Klinische Neuroradiologie - July 26, 2022 Category: Radiology Source Type: research

Functional Outcome After Mechanical Thrombectomy with or without Previous Thrombolysis
Combined intravenous therapy (IVT) and mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, the use of   IVT before MT is recently being questioned.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Manuel Machado, Marta Alves, Alberto Fior, Isabel Fragata, Ana Lu ísa Papoila, João Reis, Ana Paiva Nunes Source Type: research

An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era
In conclusion, we were able to manage the new hub-and-spoke system safely and without significant delays. The reshaping of the SU was made possible by the significant reduction of out-patient activity. The consequences of this reduction are still unknown but eventually, this emergency will suggest ways to reconsider the management and the allocation of health system resources.
Source: Frontiers in Neurology - October 15, 2020 Category: Neurology Source Type: research

Ten-Year Evaluation of the TOYOTA Prehospital Stroke Scale for Tissue Plasminogen Activator Intravenous Therapy in the Real World
Conclusions: The TOPSPIN is a simple prehospital stroke scale that includes an assessment of atrial fibrillation. Detection of atrial fibrillation in the prehospital stage may point to a higher probability of ischemic stroke.Cerebrovasc Dis 2018;46:184 –192
Source: Cerebrovascular Diseases - November 1, 2018 Category: Neurology Source Type: research

Prehospital Triage of Acute Ischemic Stroke Patients to an Intravenous tPA-Ready versus Endovascular-Ready Hospital: A Decision Analysis.
CONCLUSIONS: No single time difference between IRH and ERH transportation optimizes triage for all patients. Allowable IRH bypass time should be increased and acute ischemic stroke guidelines should incorporate the onset to EMS triage interval, IRH transportation time, and ERH transportation time. PMID: 29847193 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - June 2, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Endovascular thrombectomy alone versus combined with intravenous thrombolysis
To date, no randomized trial has directly addressed the question of whether IV tPA (IVT) improves the outcomes of IVT-eligible patients who will eventually undergo endovascular therapy (EVT) or whether a direct EVT strategy will be equally effective. We performed a systematic review and meta-analysis compare the efficacy and safety of direct EVT versus endovascular treatment with intravenous therapy (EVT+IV tPA) in adults with acute ischemic stroke.
Source: World Neurosurgery - August 17, 2017 Category: Neurosurgery Authors: Kevin Phan, Adam A. Dmytriw, Julian Maingard, Hamed Asadi, Christoph J. Griessenauer, Wyatt Ng, Kitso Kewagamang, Ralph J. Mobbs, Justin M. Moore, Christopher S. Ogilvy, Ajith J. Thomas Tags: Original article Source Type: research

Intra-arterial versus intravenous abciximab therapy for thromboembolic complications of neuroendovascular procedures: case review and meta-analysis
Conclusions Abciximab produces a high rate of angiographic improvement and a low incidence of postprocedural infarct in neuroendovascular procedures complicated by thromboemboli. IA abciximab produces greater angiographic improvement than IV treatment. Postprocedural infarction is less common in patients with complete angiographic response than in those with partial or no response.
Source: Journal of NeuroInterventional Surgery - January 12, 2017 Category: Neurosurgery Authors: Kansagra, A. P., McEachern, J. D., Madaelil, T. P., Wallace, A. N., Cross, D. T., Moran, C. J., Derdeyn, C. P. Tags: Ischemic stroke Source Type: research

Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis
The objectives of this study were to determine if a fluid responsiveness protocol would decrease progression of organ dysfunction, and a fluid responsiveness protocol would facilitate a more aggressive resuscitation. Methods: Prospective, 10-center, randomized interventional trial. Inclusion criteria: suspected sepsis and lactate 2.0 to 4.0 mmol/L. Exclusion criteria (abbreviated): systolic blood pressure more than 90 mmHg, and contraindication to aggressive fluid resuscitation. Intervention: fluid responsiveness protocol using Non-Invasive Cardiac Output Monitor (NICOM) to assess for fluid responsiveness (>10% increa...
Source: Shock - July 19, 2016 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Chelation Remains A Hopeful Heart Therapy
Maybe you know someone who has suffered a heart attack. You're concerned about their well-being, particularly if they're diabetic or suffered a large heart attack. You want to make sure that absolutely everything that can help this loved one stay healthy and alive is discussed with their doctors. Odds are very high, however, that there's one promising therapy the doctor won't tell them about: chelation therapy. Chelation therapy was designed decades ago to trap and remove serious environmental toxins like arsenic. While using it, some practitioners noted improvements in symptoms of heart disease, and chelation began to ...
Source: Healthy Living - The Huffington Post - July 1, 2016 Category: Consumer Health News Source Type: news

Mp13: important role of prothrombin time (pt) and partial thromboplastin time (ptt) in predicting tpa-related hemorrhagic transformation
Conclusions Higher PT/PTT level within 72 hr of IV tPA is early marker of tPA-induced HT. Whether these routine labs have value in symptomatic hemorrhage will require further study in a larger cohort. But this proof-of-concept study suggests that tPA efficacy can potentially be followed in real time. The development of a reliable blood test would be of clinical utility to gauge thrombolytic efficacy in real time to guide and triage adjunct treatments. Abstract MP13 Figure 1
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Deng, W., Wickham, T., McMullin, D., Feeney, K., Buonanno, F., Lo, E., Ning, M. Tags: Moderated Poster, 11:45 PM - 1:05 PM, Wednesday, April 13, 2016 Source Type: research

Reversal of antithrombotic treatment in intracranial hemorrhage--A review of current strategies and guidelines.
Abstract In the last few years, there has been a rapid increase in patients being treated with various anticoagulation and antiplatelet agents. In clinical neurology, these drugs are administered for primary and secondary stroke prevention or to avoid the consequences of immobilization of severe stroke patients. Additionally, thrombolytic intravenous therapy and, recently, intra-arterial therapy for stroke have been increasingly employed all over the world. These therapies are associated with an increased risk of hemorrhage, including the most dangerous, intracranial hemorrhage. The knowledge of the standards for ...
Source: Neurologia i Neurochirurgia Polska - August 30, 2015 Category: Neurology Authors: Grzegorski T, Andrzejewska N, Kaźmierski R Tags: Neurol Neurochir Pol Source Type: research

Advances in endovascular treatment of acute ischaemic stroke
Abstract Over the past decade, there have been rapid advancements in ischaemic stroke reperfusion treatments. However, clear clinical benefit is yet to be shown in large clinical trials. In this review, the major studies in different types of endovascular treatments including intra‐arterial thrombolysis, aspiration devices, mechanical clot retrievers and the new stent retrievers are discussed. First‐generation mechanical thrombectomy devices such as the MERCI Retriever (Stryker, Kalamazoo, MI, USA) and Penumbra aspiration device (Penumbra Inc., Alameda, CA, USA) demonstrated safety and higher rates of recanalisation in...
Source: Internal Medicine Journal - July 28, 2015 Category: Internal Medicine Authors: H. Asadi, R. Dowling, B. Yan, S. Wong, P. Mitchell Tags: Review Source Type: research

P-013 initial experience with the ace and ace64 cerebral reperfusion catheters in the endovascular treatment of acute ischemic stroke
ConclusionIn our initial experience, the ACE/ACE64 reperfusion catheters provide a safe and effective tool for the treatment of acute ischemic stroke using direct aspiration, in which we were able to recanalize (TICI 2B/3) 96.4% of cases, achieving good clinical results.DisclosuresP. Navia: None. J. Massó: None. J. Larrea: None. E. Pardo: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Navia, P., Masso, J., Larrea, J., Pardo, E. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Reversal of antithrombotic treatment in intracranial hemorrhage - A review of current strategies and guidelines.
Abstract In the last few years, there has been a rapid increase in patients being treated with various anticoagulation and antiplatelet agents. In clinical neurology, these drugs are administered for primary and secondary stroke prevention or to avoid the consequences of immobilization of severe stroke patients. Additionally, thrombolytic intravenous therapy and, recently, intra-arterial therapy for stroke have been increasingly employed all over the world. These therapies are associated with an increased risk of hemorrhage, including the most dangerous, intracranial hemorrhage. The knowledge of the standards for ...
Source: Neurologia i Neurochirurgia Polska - July 1, 2015 Category: Neurology Authors: Grzegorski T, Andrzejewska N, Kaźmierski R Tags: Neurol Neurochir Pol Source Type: research