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Total 19 results found since Jan 2013.

Ten-Year Evaluation of the TOYOTA Prehospital Stroke Scale for Tissue Plasminogen Activator Intravenous Therapy in the Real World
Conclusions: The TOPSPIN is a simple prehospital stroke scale that includes an assessment of atrial fibrillation. Detection of atrial fibrillation in the prehospital stage may point to a higher probability of ischemic stroke.Cerebrovasc Dis 2018;46:184 –192
Source: Cerebrovascular Diseases - November 1, 2018 Category: Neurology Source Type: research

Prehospital Triage of Acute Ischemic Stroke Patients to an Intravenous tPA-Ready versus Endovascular-Ready Hospital: A Decision Analysis.
CONCLUSIONS: No single time difference between IRH and ERH transportation optimizes triage for all patients. Allowable IRH bypass time should be increased and acute ischemic stroke guidelines should incorporate the onset to EMS triage interval, IRH transportation time, and ERH transportation time. PMID: 29847193 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - June 2, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Advances in endovascular treatment of acute ischaemic stroke
Abstract Over the past decade, there have been rapid advancements in ischaemic stroke reperfusion treatments. However, clear clinical benefit is yet to be shown in large clinical trials. In this review, the major studies in different types of endovascular treatments including intra‐arterial thrombolysis, aspiration devices, mechanical clot retrievers and the new stent retrievers are discussed. First‐generation mechanical thrombectomy devices such as the MERCI Retriever (Stryker, Kalamazoo, MI, USA) and Penumbra aspiration device (Penumbra Inc., Alameda, CA, USA) demonstrated safety and higher rates of recanalisation in...
Source: Internal Medicine Journal - July 28, 2015 Category: Internal Medicine Authors: H. Asadi, R. Dowling, B. Yan, S. Wong, P. Mitchell Tags: Review Source Type: research

Physiologic imaging in acute stroke: Patient selection.
Authors: Morgan CD, Stephens M, Zuckerman SL, Waitara MS, Morone PJ, Dewan MC, Mocco J Abstract Treatment of acute stroke is changing, as endovascular intervention becomes an important adjunct to tissue plasminogen activator. An increasing number of sophisticated physiologic imaging techniques have unique advantages and applications in the evaluation, diagnosis, and treatment-decision making of acute ischemic stroke. In this review, we first highlight the strengths, weaknesses, and possible indications for various stroke imaging techniques. How acute imaging findings in each modality have been used to predict funct...
Source: Interventional Neuroradiology - June 13, 2015 Category: Radiology Tags: Interv Neuroradiol Source Type: research

P-013 initial experience with the ace and ace64 cerebral reperfusion catheters in the endovascular treatment of acute ischemic stroke
ConclusionIn our initial experience, the ACE/ACE64 reperfusion catheters provide a safe and effective tool for the treatment of acute ischemic stroke using direct aspiration, in which we were able to recanalize (TICI 2B/3) 96.4% of cases, achieving good clinical results.DisclosuresP. Navia: None. J. Massó: None. J. Larrea: None. E. Pardo: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Navia, P., Masso, J., Larrea, J., Pardo, E. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Comparative efficacy of different acute reperfusion therapies for acute ischemic stroke: a comprehensive benefit–risk analysis of clinical trials
ConclusionIntravenous thrombolysis (IVT) with TNK and sonothrombolysis have the higher BRR among investigational reperfusion therapies. The combination of sonothrombolysis with IV administration of TNK appears a potentially promising therapeutic option deserving further investigation. Intravenous (IV) thrombolysis with tenecteplase (TNK) and sonothrombolysis appear to have the higher benefit‐to‐risk ratios among investigational reperfusion therapies. The combination of sonothrombolysis with IV administration of TNK could have a potentially promising therapeutic option that deserves further investigation.
Source: Brain and Behavior - September 10, 2014 Category: Neurology Authors: Georgios Tsivgoulis, John Alleman, Aristeidis H. Katsanos, Andrew D. Barreto, Martin Kohrmann, Peter D. Schellinger, Carlos A Molina, Andrei V. Alexandrov Tags: Review Source Type: research

An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era
In conclusion, we were able to manage the new hub-and-spoke system safely and without significant delays. The reshaping of the SU was made possible by the significant reduction of out-patient activity. The consequences of this reduction are still unknown but eventually, this emergency will suggest ways to reconsider the management and the allocation of health system resources.
Source: Frontiers in Neurology - October 15, 2020 Category: Neurology Source Type: research

Functional Outcome After Mechanical Thrombectomy with or without Previous Thrombolysis
Combined intravenous therapy (IVT) and mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, the use of   IVT before MT is recently being questioned.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Manuel Machado, Marta Alves, Alberto Fior, Isabel Fragata, Ana Lu ísa Papoila, João Reis, Ana Paiva Nunes Source Type: research

Reversal of antithrombotic treatment in intracranial hemorrhage - A review of current strategies and guidelines.
Abstract In the last few years, there has been a rapid increase in patients being treated with various anticoagulation and antiplatelet agents. In clinical neurology, these drugs are administered for primary and secondary stroke prevention or to avoid the consequences of immobilization of severe stroke patients. Additionally, thrombolytic intravenous therapy and, recently, intra-arterial therapy for stroke have been increasingly employed all over the world. These therapies are associated with an increased risk of hemorrhage, including the most dangerous, intracranial hemorrhage. The knowledge of the standards for ...
Source: Neurologia i Neurochirurgia Polska - July 1, 2015 Category: Neurology Authors: Grzegorski T, Andrzejewska N, Kaźmierski R Tags: Neurol Neurochir Pol Source Type: research

Reversal of antithrombotic treatment in intracranial hemorrhage--A review of current strategies and guidelines.
Abstract In the last few years, there has been a rapid increase in patients being treated with various anticoagulation and antiplatelet agents. In clinical neurology, these drugs are administered for primary and secondary stroke prevention or to avoid the consequences of immobilization of severe stroke patients. Additionally, thrombolytic intravenous therapy and, recently, intra-arterial therapy for stroke have been increasingly employed all over the world. These therapies are associated with an increased risk of hemorrhage, including the most dangerous, intracranial hemorrhage. The knowledge of the standards for ...
Source: Neurologia i Neurochirurgia Polska - August 30, 2015 Category: Neurology Authors: Grzegorski T, Andrzejewska N, Kaźmierski R Tags: Neurol Neurochir Pol Source Type: research

Start, Stop, Continue? The Benefit of Overlapping Intravenous Thrombolysis and Mechanical Thrombectomy
ConclusionThe presented results support the approach of continuing and completing a  simultaneous administration of intravenous thrombolysis during mechanical thrombectomy procedures.
Source: Klinische Neuroradiologie - July 26, 2022 Category: Radiology Source Type: research

Bilateral carotid artery dissection in a severe preeclamptic setting: An unusual cause of postpartum headache.
Abstract A 30-year-old woman with severe preeclampsia presented at 27weeks of amenorrhea with left headache, neck pain, blurred vision and numbness of left hemiface that resolved spontaneously within 2hours. A week later, hypertension remained poorly controlled despite combination of nicardipine and labetalol intravenous therapy; an urgent caesarean section was eventually performed due to onset of HELLP syndrome. At day 5 postpartum, the patient had a Horner syndrome with right ipsilateral disabling tinnitus. A CT-angiography of supra-aortic trunks was performed urgently; it showed a bilateral carotid arterial dis...
Source: Annales Francaises d'Anesthesie et de Reanimation - April 1, 2013 Category: Anesthesiology Authors: Hoffmann C, Augé M, Falzone E, Martel-Jacob S, Mercier FJ Tags: Ann Fr Anesth Reanim Source Type: research

Strokes in the anterior circulation: comparison between bridging and intravenous thrombolysis
ConclusionsOur results suggest that patients treated with a bridging approach were more likely to have minimal or no deficit at all at 3 months as compared to the IV treated group.
Source: Acta Neurologica Scandinavica - October 27, 2014 Category: Neurology Authors: R. F. Sztajzel, H. Muller, L. Sekoranja, A. Viaccoz, V. Mendez Pereira, A. P. Narata, K. Lovblad, S. Altrichter, P. Michel Tags: Original Article Source Type: research

Mp13: important role of prothrombin time (pt) and partial thromboplastin time (ptt) in predicting tpa-related hemorrhagic transformation
Conclusions Higher PT/PTT level within 72 hr of IV tPA is early marker of tPA-induced HT. Whether these routine labs have value in symptomatic hemorrhage will require further study in a larger cohort. But this proof-of-concept study suggests that tPA efficacy can potentially be followed in real time. The development of a reliable blood test would be of clinical utility to gauge thrombolytic efficacy in real time to guide and triage adjunct treatments. Abstract MP13 Figure 1
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Deng, W., Wickham, T., McMullin, D., Feeney, K., Buonanno, F., Lo, E., Ning, M. Tags: Moderated Poster, 11:45 PM - 1:05 PM, Wednesday, April 13, 2016 Source Type: research