Comparative efficacy of different acute reperfusion therapies for acute ischemic stroke: a comprehensive benefit–risk analysis of clinical trials

ConclusionIntravenous thrombolysis (IVT) with TNK and sonothrombolysis have the higher BRR among investigational reperfusion therapies. The combination of sonothrombolysis with IV administration of TNK appears a potentially promising therapeutic option deserving further investigation. Intravenous (IV) thrombolysis with tenecteplase (TNK) and sonothrombolysis appear to have the higher benefit‐to‐risk ratios among investigational reperfusion therapies. The combination of sonothrombolysis with IV administration of TNK could have a potentially promising therapeutic option that deserves further investigation.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fbrb3.279

Source: Brain and Behavior - September 10, 2014 Category: Neurology Authors: Georgios Tsivgoulis, John Alleman, Aristeidis H. Katsanos, Andrew D. Barreto, Martin Kohrmann, Peter D. Schellinger, Carlos A Molina, Andrei V. Alexandrov Tags: Review Source Type: research