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Specialty: Toxicology

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Total 137 results found since Jan 2013.

Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO ‐1 and calcium signaling pathways
In conclusion, here we provide the first evidence that demonstrates narcissin-induced developmental toxicity and cardiotoxicity in zebrafish via Nrf2/HO-1 and calcium signaling pathways for the first time.
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Shuo Gao, Chaoyi Zhou, Linhua Hou, Kuo Xu, Yun Zhang, Xue Wang, Jianheng Li, Kechun Liu, Qing Xia Tags: RESEARCH ARTICLE Source Type: research

Examining the subchronic (28-day) effects of aqueous Cd-BaP co-exposure on detoxification capacity and cardiac function in adult zebrafish (Danio rerio)
Aquat Toxicol. 2023 Aug 27;263:106672. doi: 10.1016/j.aquatox.2023.106672. Online ahead of print.ABSTRACTThe present study aimed to examine the effects of environmentally relevant concentrations of cadmium (Cd) and Benzo[a]Pyrene (BaP) in the adult zebrafish (Danio rerio). To this end, fish were exposed to either 1 or 10 μg/L Cd or 0.1 or 1 μg/L BaP in isolation, or a co-exposure containing a mixture of the two toxicants. Our results showed extensive modulation of the expression of key antioxidant genes (GPx, SOD1, catalase), detoxifying genes (MT1, MT2, CYP1A1) and a stress biomarker (HSP70) differing between control, s...
Source: Aquatic Toxicology - September 6, 2023 Category: Toxicology Authors: Vladimir Kodzhahinchev Mahesh Rachamalla Ahmad Al-Dissi Som Niyogi Lynn P Weber Source Type: research

Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway
This study aimed to investigate the protective effects of SIL against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, and the mechanisms involved. Firstly, the toxicity of SIL was evaluated, and safe concentrations were chosen for subsequent experiments. Then, SIL exerts significant neuroprotection against hypoxia/reoxygenation (HR) injury in N2a cells, as manifested by increased cell viability, decreased apoptotic rate, LDH, and ROS generation. Additionally, SIL was found to inhibit HR-induced apoptosis, mitochondria dysfunction, and oxidative stress. However, silencing of GAS6 inhibited the neuroprotecti...
Source: Toxicology - August 6, 2023 Category: Toxicology Authors: Weiping Li Zhe Zhang Jiawen Li Jun Mu Meng Sun Xue Wu Xiaochen Niu Yang Yang Huanle Yan Xiaoling Xu Chengxu Xue Lu Qian Ye Tian Source Type: research

Effect Of Persistent Organic Pollutants In Patients With Ischemic Stroke And All Stroke: A Systematic Review And Meta-Analysis
Toxicology. 2023 May 31:153567. doi: 10.1016/j.tox.2023.153567. Online ahead of print.ABSTRACTThe role of environmental contaminants and their association with stroke is still being determined. Association has been shown with air pollution, noise, and water pollution; however, the results are inconsistent across studies. A systematic review and meta-analysis of the effect of persistent organic pollutants (POP) in ischemic stroke patients were conducted; a comprehensive literature search was carried out until 30th June 2021 from different databases. The quality of all the articles which met our inclusion criteria was assess...
Source: Toxicology - June 2, 2023 Category: Toxicology Authors: Priya Dev Kamalesh Chakravarty Manoj Pandey Rakesh Ranjan Mareena Cyriac Vijaya Nath Mishra Abhishek Pathak Source Type: research

Early versus late injections of Botulinumtoxin type A in post-stroke spastic movement disorder: A literature review
Toxicon. 2023 May 3:107150. doi: 10.1016/j.toxicon.2023.107150. Online ahead of print.ABSTRACTPost-stroke spastic movement disorder (PS-SMD) is one of the main causes of severe disability in the chronic phase after stroke. The prevalence of SMD rises up with time after stroke to more than 28% in the chronic phase, and its secondary complications such as contracture, abnormal postures and/or movement patterns, spasticity-associated pain, also increases with time after stroke when physical and medical management of PS-SMD had been delayed in the early stroke phase. It has been published by several controlled studies that the...
Source: Toxicon - May 5, 2023 Category: Toxicology Authors: J örg Wissel Songjin Ri Anatol Kivi Source Type: research

Understanding the molecular mechanisms of statin pleiotropic effects
Arch Toxicol. 2023 Apr 21. doi: 10.1007/s00204-023-03492-6. Online ahead of print.ABSTRACTStatins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These medications not only reduce low-density lipoprotein cholesterol (LDL-C) via inhibition of 3-hydroxy-3-methylglutarate attached to CoA reductase, the key rate-limiting step in the cholesterol biosynthetic pathway, but also upregulate expression of the low-density lipoprotein receptor, improving serum clearance. Given LDL-C is a causal risk factor for the development of atherosclerosis, these complementary mechanisms ...
Source: Archives of Toxicology - April 21, 2023 Category: Toxicology Authors: Charles A German James K Liao Source Type: research