Effect Of Persistent Organic Pollutants In Patients With Ischemic Stroke And All Stroke: A Systematic Review And Meta-Analysis

Toxicology. 2023 May 31:153567. doi: 10.1016/j.tox.2023.153567. Online ahead of print.ABSTRACTThe role of environmental contaminants and their association with stroke is still being determined. Association has been shown with air pollution, noise, and water pollution; however, the results are inconsistent across studies. A systematic review and meta-analysis of the effect of persistent organic pollutants (POP) in ischemic stroke patients were conducted; a comprehensive literature search was carried out until 30th June 2021 from different databases. The quality of all the articles which met our inclusion criteria was assessed using Newcastle-Ottawa scaling; five eligible studies were included in our systematic review. The most studied POP in ischemic stroke was polychlorinated biphenyls (PCBs), and they have shown a trend for association with ischemic stroke. The study also revealed that living near a source of POPs contamination constitutes a risk of exposure and an increased risk of ischemic stroke. Although our study provides a strong positive association of POPs with ischemic stroke, more extensive studies must be conducted to prove the association.PMID:37268249 | DOI:10.1016/j.tox.2023.153567
Source: Toxicology - Category: Toxicology Authors: Source Type: research