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Total 749 results found since Jan 2013.

The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke
The immune response to ischemic stroke is an area of study that is at the forefront of stroke research and presents promising new avenues for treatment development. Upon cerebral vessel occlusion, the innate immune system is activated by danger-associated molecular signals from stressed and dying neurons. Microglia, an immune cell population within the central nervous system which phagocytose cell debris and modulate the immune response via cytokine signaling, are the first cell population to become activated. Soon after, monocytes arrive from the peripheral immune system, differentiate into macrophages, and further aid in...
Source: Frontiers in Immunology - June 20, 2022 Category: Allergy & Immunology Source Type: research

Review of the effects and Mechanisms of microglial autophagy in ischemic stroke
Int Immunopharmacol. 2022 Jul;108:108761. doi: 10.1016/j.intimp.2022.108761. Epub 2022 Jun 4.ABSTRACTStroke is a dysfunction caused by acute cerebrovascular disease, which has become the second leading cause of death in the world, resulting in a heavy burden on family and society. As a cellular adaptive mechanism, autophagy denoted a rather pivotal role in the process of ischemic stroke. Recent studies have suggested that autophagy of microglia has an important effect on polarization of phenotype and regulation of neuroinflammation, which implies that regulating autophagy of microglia may be a promising therapeutic strateg...
Source: International Immunopharmacology - June 22, 2022 Category: Allergy & Immunology Authors: Kaichao Hu Yan Gao Shifeng Chu Naihong Chen Source Type: research

CD11b < sup > high < /sup > B Cells Increase after Stroke and Regulate Microglia
J Immunol. 2022 Jun 22:ji2100884. doi: 10.4049/jimmunol.2100884. Online ahead of print.ABSTRACTRecent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different B cell subsets have been proposed on the basis of expression levels of transcription factors (e.g., T-bet) as well as specific surface proteins. CD11b (α-chain of integrin) is expressed by several immune cell types and is involved in regulation of cell motility, phagocytosis, and other essential functions of host immunity. Although B cells express CD11b, the CD11bhigh subset of B cells has not been we...
Source: Journal of Immunology - June 22, 2022 Category: Allergy & Immunology Authors: Janelle M Korf Pedram Honarpisheh Eric C Mohan Anik Banerjee Maria P Blasco-Conesa Parisa Honarpisheh Gary U Guzman Romeesa Khan Bhanu P Ganesh Amy L Hazen Juneyoung Lee Aditya Kumar Louise D McCullough Anjali Chauhan Source Type: research

Spectratype analysis of clonal T cell expansion in murine experimental stroke
Abstract: T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this study aimed to directly investigate antigen-dependent clonal T cell expansion after experimental brain ischemia using spectratype/immunoscope analysis. We detected clonal T cell expansion in ischemic brains and to a lesser extent in secondary lymphatic organs and characterized its time course. This is the first study presenting direct evidence of clonal T cell expansion after stroke — however, with delayed kinetics t...
Source: Journal of Neuroimmunology - February 26, 2013 Category: Allergy & Immunology Authors: Arthur Liesz, Simone Karcher, Roland Veltkamp Tags: Research Papers Source Type: research

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke
This study provides new information about the sex specific mechanisms of the peripheral immune response in neurodegeneration after stroke and demonstrates the need for representation of both sexes in basic and clinical stroke research.
Source: Journal of Neuroimmunology - November 25, 2014 Category: Allergy & Immunology Authors: Abby L. Dotson, Jianming Wang, Julie Saugstad, Stephanie J. Murphy, Halina Offner Source Type: research

Correlation of deglutition in subacute ischemic stroke patients with peripheral blood adaptive immunity: Essential amino acid improvement.
Authors: Aquilani R, Emilio B, Dossena M, Baiardi P, Testa A, Boschi F, Viglio S, Iadarola P, Pasini E, Verri M Abstract We aimed to document in stroke patients peripheral blood immune cell profiles, their relations with neuro-functional tests, and any possible influence of supplemented essential amino acids (EAAs) may have on both the immune system and the relationship of the latter with neuro-function.Forty-two dysphagic stroke patients (27 men; 71±9 years) underwent bio-humoral measurements, neuro-functional tests, including Functional Independence Measure (FIM) and Dysphagia Outcome and Severity Scale (DOSS), ...
Source: International Journal of Immunopathology and Pharmacology - November 18, 2015 Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research

Sex differences in regulatory cells in experimental stroke.
Abstract Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifying mechanisms in female vs. male mice. The current study demonstrated smaller infarcts and increased levels of regulatory CD19(+)CD5(+)CD1d(hi) B10 cells as well as anti-inflammatory CD11b(+)CD206(+) microglia/macrophages in the ipsilateral vs. contralateral hemisphere of female but not male ...
Source: Cellular Immunology - June 8, 2017 Category: Allergy & Immunology Authors: Seifert HA, Benedek G, Liang J, Nguyen H, Kent G, Vandenbark AA, Saugstad JA, Offner H Tags: Cell Immunol Source Type: research

XQ-1H protects against ischemic stroke by regulating microglia polarization through PPAR γ pathway in mice.
In conclusion, the present study demonstrates that XQ-1H alleviated ischemic stroke by regulating balance of pro-/anti-inflammatory microglia polarization through PPARγ pathway both in vivo and in vitro, offering an alternative medication for stroke associated with inflammation. PMID: 29475098 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - February 20, 2018 Category: Allergy & Immunology Authors: Liu R, Diao J, He S, Li B, Fei Y, Li Y, Fang W Tags: Int Immunopharmacol Source Type: research

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke
Stroke-induced immunodepression is an independent risk factor for stroke-associated pneumonia (SAP). Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. However, whether GM-CSF restores immune function after stroke preventing SAP and improving outcome is unknown. Here, we demonstrated that GM-CSF treatment improved peripheral and pulmonary leukocyte numbers, peripheral cytokine responses, lowered lung bacterial burden in the early course and improved long-term functional outcome after experimental stroke.
Source: Journal of Neuroimmunology - March 9, 2018 Category: Allergy & Immunology Authors: Claudia Dames, Katarzyna Winek, Yasmin Beckers, Odilo Engel, Andreas Meisel, Christian Meisel Source Type: research

Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF- κB p65/Hif-1α Signaling Pathway.
Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway. J Immunol. 2019 Feb 01;: Authors: Liu R, Liao XY, Pan MX, Tang JC, Chen SF, Zhang Y, Lu PX, Lu LJ, Zou YY, Qin XP, Bu LH, Wan Q Abstract Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal and microglial death in ischemic stroke injury. Neuroinflammation has been considered a major contributor ...
Source: Journal of Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Liu R, Liao XY, Pan MX, Tang JC, Chen SF, Zhang Y, Lu PX, Lu LJ, Zou YY, Qin XP, Bu LH, Wan Q Tags: J Immunol Source Type: research

Risk of acute myocardial infarction and ischemic stroke in patients with asthma exacerbation: A population-based, self-controlled case series study
CONCLUSIONSIn this population-based study of adults with asthma, the risk of acute myocardial infarction and ischemic stroke increased significantly after asthma exacerbation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 17, 2019 Category: Allergy & Immunology Source Type: research

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