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Specialty: Allergy & Immunology
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Total 749 results found since Jan 2013.
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF- κB mediated neutrophil infiltration in thromboembolic stroke rats
Int Immunopharmacol. 2021 Feb 28;94:107507. doi: 10.1016/j.intimp.2021.107507. Online ahead of print.ABSTRACTHemorrhagic transformation (HT) is a frequent complication of ischemic stroke after thrombolytic therapy and seriously affects the prognosis of stroke. Due to the limited therapeutic window and hemorrhagic complications, tissue plasminogen activator (t-PA) is underutilized in acute ischemic stroke. Currently, there are no clinically effective drugs to decrease the incidence of t-PA-induced HT. Hypoxia-inducible factor 1 (HIF-1) is an important transcription factor that maintains oxygen homeostasis and mediates neuro...
Source: International Immunopharmacology - March 3, 2021 Category: Allergy & Immunology Authors: Linglei Kong Yinzhong Ma Zhiyuan Wang Nannan Liu Guodong Ma Chengdi Liu Ruili Shi Guanhua Du Source Type: research
Nanoparticles of resveratrol attenuates oxidative stress and inflammation after ischemic stroke in rats
Int Immunopharmacol. 2021 Mar 3;94:107494. doi: 10.1016/j.intimp.2021.107494. Online ahead of print.ABSTRACTResveratrol is a nutraceutical compound that has exciting pharmacological potential in different diseases, including stroke. Due to its low bioavailability, the efficacy of resveratrol is minimal. Hence, the present study is aimed to synthesize and characterize nanoparticles of resveratrol (NR) followed by evaluating the neuroprotective role and elucidate the mechanism of NR in a rat model of middle cerebral artery occlusion (MCAO). Male Wistar rats (280-300 g) were pretreated with various doses (125 µg, 250 µg, an...
Source: International Immunopharmacology - March 6, 2021 Category: Allergy & Immunology Authors: Mohammad Ashafaq M Intakhab Alam Andleeb Khan Farah Islam Gulrana Khuwaja Sohail Hussain Raisuddin Ali Saeed Alshahrani Hafiz Antar Makeen Hassan A Alhazmi Mohammed Al Bratty Fakhrul Islam Source Type: research
Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice
CONCLUSION: Our results reveal pharmacological effect of RIPC in promoting microglia/macrophage transferring from M1 to M2 phenotype after MCAO/R in mice, which provides theoretical support for the therapeutic effect of RIPC in ischemic stroke.PMID:33688509 | PMC:PMC7910075 | DOI:10.1155/2021/6688053
Source: Journal of Immunology Research - March 10, 2021 Category: Allergy & Immunology Authors: Dong Han Jue Wang Lulu Wen Miao Sun Hang Liu Yan Gao Source Type: research
Efficacy and safety of intratracheal IFN- γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN- γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the development of pneumonia after middle cerebral artery occlusion (MCAo). In the present study, we investigated the efficacy of intratracheal IFN-γ treatment to prevent SAP and demonstrated that modest benef its on pulmonary cytokine response in IFN-γ treated stroke mice did not prevent spontaneously developing infections and even slightly reduced bacterial clearance of aspirated pneumococci.
Source: Journal of Neuroimmunology - April 3, 2021 Category: Allergy & Immunology Authors: Sandra Jagdmann, Daniel Berchtold, Birgitt Gutbier, Martin Witzenrath, Andreas Meisel, Christian Meisel, Claudia Dames Source Type: research
Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study
To explore the role of systemic inflammation in post-stroke delirium, we investigated the level of two inflammatory mediators: high mobility group box 1 (HMGB1) and galectin-3 binding protein (Gal-3BP). Of 571 stroke patients, we compared plasma levels of HMGB1 and Gal-3BP in 79 delirious patients with 81 non-delirious patients matched for age and stroke severity. Delirious patients had higher Gal-3BP level (median: 1440 vs 1053 ng/mL, P
Source: Journal of Neuroimmunology - April 16, 2021 Category: Allergy & Immunology Authors: Elzbieta Klimiec-Moskal, Paulina Pasinska, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic Tags: Short Communication Source Type: research
Plasma Concentration of Tumor Necrosis Factor-Stimulated Gene-6 as a Novel Diagnostic and 3-Month Prognostic Indicator in Non-Cardioembolic Acute Ischemic Stroke
ConclusionsPlasma TSG-6 concentration was a novel indicator for non-cardioembolic AIS diagnosis and 3-month prognosis. Elevated TSG-6-to-interleukin-8 ratio might suggest a 3-month favorable outcome.
Source: Frontiers in Immunology - February 10, 2022 Category: Allergy & Immunology Source Type: research
HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy
ConclusionsHDAC3-regulated PGE2 production by microglia constitutes phobic anxiety susceptibility after stroke and a protective approach of gamma visual stimulation can be a candidate new therapy.
Source: Frontiers in Immunology - February 18, 2022 Category: Allergy & Immunology Source Type: research
Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
Despite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There is renewed attention on peripheral inflammatory signaling as a way of modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been the focus for understanding the mechanisms of sickness behavior, which is an adaptive autonomic, neuroendocrine, and behavioral response to a peripheral inflammation. It is mediated by humoral and neural pathways that mainly involve the circumventricular organs and vagal nerve, respectively. In this review we address the question of how sepsis and str...
Source: Frontiers in Immunology - April 7, 2022 Category: Allergy & Immunology Source Type: research
Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia
In conclusion, insufficient resolution of NETs, e.g. by endogenous DNases or protection of NETs against degradation by embedded factors like the antimicrobial peptide LL-37 might thus be an important factor in the pathology of VITT besides increased NET-formation. On the basis of these findings, we discuss the potential implications of the mechanisms of disturbed NETs-degradation for diagnostic and therapeutic approaches in VITT-related thrombogenesis, other auto-immune disorders and beyond.
Source: Frontiers in Immunology - May 10, 2022 Category: Allergy & Immunology Source Type: research
Hirudin alleviates acute ischemic stroke by inhibiting NLRP3 inflammasome-mediated neuroinflammation: In vivo and in vitro approaches
In this study, hirudin with a dose of 10-40 mg/kg was given to middle cerebral artery occlusion/reperfusion mice. Hirudin markedly constrained cerebral infarct area in a dose-dependent manner, and significantly improved locomotor disability at 40 mg/kg dose. Similar to MCC950, a selective NLRP3 inflammasome inhibitor, hirudin inhibited M1 polarization and promoted M2 polarization. It also strikingly suppressed the ischemia-induced overexpression of NLRP3 and its downstream components, caspase-1, apoptosis-associated speck-like protein (ASC), and interleukin-1β (IL-1β). Hirudin and MCC950 equivalently protected viability ...
Source: International Immunopharmacology - June 20, 2022 Category: Allergy & Immunology Authors: Wen-Qi Li Zong-Shi Qin Shuang Chen Dan Cheng Si-Chang Yang Yuen Man Mandy Choi Buggic Chu Wei-Hai Zhou Zhang-Jin Zhang Source Type: research
