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Specialty: Allergy & Immunology

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Total 749 results found since Jan 2013.

Research progress on the role of hormones in ischemic stroke
Ischemic stroke is a major cause of death and disability around the world. However, ischemic stroke treatment is currently limited, with a narrow therapeutic window and unsatisfactory post-treatment outcomes. Therefore, it is critical to investigate the pathophysiological mechanisms following ischemic stroke brain injury. Changes in the immunometabolism and endocrine system after ischemic stroke are important in understanding the pathophysiological mechanisms of cerebral ischemic injury. Hormones are biologically active substances produced by endocrine glands or endocrine cells that play an important role in the organismâ€...
Source: Frontiers in Immunology - December 7, 2022 Category: Allergy & Immunology Source Type: research

Systematic review and network meta-analysis of stroke prevention treatments in patients with atrial fibrillation.
CONCLUSION: All oral anticoagulants reduce the risk of stroke in AF patients. Some novel oral anticoagulants are associated with a lower stroke and/or major bleeding risk than warfarin. In addition to the safety and effectiveness of drug therapy, as reported in this study, individual treatment recommendations should also consider the patient's underlying stroke and bleeding risk profile. PMID: 27570467 [PubMed]
Source: Clinical Pharmacology: Advances and Applications - August 31, 2016 Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research

Regulatory B cells in Experimental Stroke.
This article is protected by copyright. All rights reserved. PMID: 29313944 [PubMed - as supplied by publisher]
Source: Immunology - January 3, 2018 Category: Allergy & Immunology Authors: Seifert HA, Vandenbark AA, Offner H Tags: Immunology Source Type: research

Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients.
CONCLUSION: Treg proportions are reduced in ischemic stroke patients and increased by treatment with high-dose PARP-1 inhibitor JPI-289. The PARP-1 inhibitor also had a possible anti-inflammatory effect on cytokine levels, and may ameliorate the outcome of ischemic stroke by up-regulating Tregs. PMID: 29709770 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - April 27, 2018 Category: Allergy & Immunology Authors: Noh MY, Lee WM, Lee SJ, Kim HY, Kim SH, Kim YS Tags: Int Immunopharmacol Source Type: research

Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke
In conclusion, these data highlighted the involvement of the CXCL8-CXCR2 chemotactic axis in the recruitment of granulocytes and NK cells in ischemic stroke. Furthermore, miR-4437 was suggested as a novel target for treating ischemic stroke, while the serum CXCL8 level could be a prognostic factor for ischemic stroke.
Source: Molecular Immunology - August 9, 2018 Category: Allergy & Immunology Source Type: research

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic transformation. The rapid activation of immune cells plays a critical role in BBB disruption after ischemic stroke. Infiltrating blood-borne immune cells (neutrophils, monocytes, and T lymphocytes) increase BBB permeability, as they cause microvascular disorder and secrete inflammation-associated molecules. In contrast, they promote BBB repair and angiogenesis in the latter phase of ischemic stroke. The profound immunological effects of cerebral immun...
Source: Frontiers in Immunology - June 23, 2021 Category: Allergy & Immunology Source Type: research

Lack of lymphocytes exacerbate heat stroke severity in male mice through enhanced inflammatory response
Int Immunopharmacol. 2021 Oct 6;101(Pt A):108206. doi: 10.1016/j.intimp.2021.108206. Online ahead of print.ABSTRACTThough it has long been thought that the immune system is implicated in the pathophysiology of heat stroke, the underlying mechanisms are still poorly understood. As it has been reported in the literature that lymphocyte disturbance occurs in heat stroke patients or animals, we attempted to seek experimental evidence to define the role of lymphocytes in the pathophysiology of heat stroke. In our study, we used male Balb/c mice to establish a passive heat stroke model. We found that lymphocyte-deficient Severe ...
Source: International Immunopharmacology - October 9, 2021 Category: Allergy & Immunology Authors: Yulong Tan Xiaoqian Liu Xueting Yu Tingting Shen Zeze Wang Zhen Luo Xue Luo Xuesen Yang Source Type: research

Impact of ankylosing spondylitis on stroke limited to specific subtypes: Evidence from Mendelian randomization study
ConclusionThis study suggests that the possible causative impact of genetically predicted AS on stroke may be restricted to the CES and LAS subtypes.
Source: Frontiers in Immunology - January 19, 2023 Category: Allergy & Immunology Source Type: research

Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018
ConclusionIn asthmatics, higher levels of SII and SIRI significantly increased the prevalence of stroke, with its association being more pronounced in individuals with coexisting obesity and hyperlipidaemia. SII and SIRI are relatively stable novel inflammatory markers in the asthmatic population, with SIRI having a better predictive value for stroke prevalence than SII.
Source: Frontiers in Immunology - August 4, 2023 Category: Allergy & Immunology Source Type: research

Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection
ConclusionThis is the first report to demonstrate a significant reduction of lymphocytes and multiple proinflammatory chemokines in the lungs following ischemic stroke in mice. These findings suggest that ischemic stroke directly impacts pulmonary immunity.
Source: Immunity, Inflammation and Disease - November 4, 2019 Category: Allergy & Immunology Authors: Breanne Y. Farris, Kelly L. Monaghan, Wen Zheng, Courtney D. Amend, Heng Hu, Amanda G. Ammer, James E. Coad, Xuefang Ren, Edwin C. K. Wan Tags: ORIGINAL RESEARCH Source Type: research

Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke.
We examined risk factors for unfavorable outcome following stroke occurrence including serum antibody titers to periodontal pathogens. The enrolled cohort included 534 patients who had experienced an acute stroke, who were divided into favorable (n=337) and unfavorable (n=197) outcome groups according to modified ranking scale (mRS) score determined at 3 months after onset (favorable: score 0 or 1, unfavorable: score 2 to 6. The associations of risk factors with unfavorable outcome, including serum titers of IgG antibodies to 16 periodontal pathogens, were examined. Logistic regression analysis showed that the initial Nati...
Source: Clinical and Developmental Immunology - March 9, 2020 Category: Allergy & Immunology Authors: Nishi H, Hosomi N, Ohta K, Aoki S, Nakamori M, Nezu T, Shigeishi H, Shintani T, Obayashi T, Ishikawa K, Kinoshita N, Shiga Y, Sugiyama M, Ohge H, Maruyama H, Kawaguchi H, Kurihara H Tags: Clin Exp Immunol Source Type: research

Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade
Despite the enormous progress in the understanding of the course of the ischemic stroke over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and significantly improves neurological functions in stroke patients has still not been achieved. The reasons for this state are unclear, but it is obvious that the cerebral ischemia and reperfusion cascade is a highly complex phenomenon, which includes the intense neuroinflammatory processes, and comorbid stroke risk factors strongly worsen stroke outcomes and likely make a substantial contribution to the pathophysiology of the ischemia/reperfusio...
Source: Frontiers in Immunology - November 15, 2021 Category: Allergy & Immunology Source Type: research