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Specialty: Neurology
Therapy: Thrombolytic Therapy
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Total 551 results found since Jan 2013.
Safety and outcomes of intravenous thrombolytic therapy in ischemic stroke patients with COVID-19: CASCADE initiative
There is little information regarding the safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke and COVID-19.
Source: Journal of Stroke and Cerebrovascular Diseases - September 19, 2021 Category: Neurology Authors: Payam Sasanejad, Leila Afshar Hezarkhani, Shahram Arsang-Jang, Georgios Tsivgoulis, Abdoreza Ghoreishi, Barlinn Kristian, Jan Rahmig, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Afshin Borhani-Haghighi, Payam Sariaslani, Athena Sharifi-Razavi, Kavian Ghandeh Source Type: research
Cryptogenic Stroke Caused by Pulmonary Arterial Venous Malformation with Massive Right-to-Left Shunt: A Case Report
ConclusionsPAVM is an important risk factor for PE and CS and should not be ignored as a possible etiology in stroke patients without any other risk factors. CTA of the pulmonary artery is the recommended gold standard for diagnosing and locating a PAVM. Thrombolytic therapy within the time window combined with transcatheter device occlusion of arteriovenous malformation and rehabilitation training may benefit the recovery of patients with CS caused by PE resulting from PAVM.
Source: Neurology and Therapy - September 3, 2021 Category: Neurology Source Type: research
Reperfusion therapy in a patient with early recurrence of ischemic stroke
We report a case addressing this issue.Case presentationWe present a patient who was successfully treated by mechanical thrombectomy (MT) for middle cerebral artery occlusion. Due to an early stroke recurrence, within 72 h after the first MT, he received systemic thrombolysis and repeated MT was performed with excellent clinical outcome.DiscussionWe discuss the aspects of reperfusion therapy for patients experiencing early stroke recurrence. Consideration was given to stroke etiology and off-label use of thrombolytic therapy. Also, effectiveness of repeated MT for early re-occlusion of initially reanalyzed vessel was eva...
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research
Workforce Attachment after Ischemic Stroke – The Importance of Time to Thrombolytic Therapy
The ability to remain in employment addresses an important consequence of stroke beyond the usual clinical parameters. However, data on the association between time to intravenous thrombolysis and workforce attachment in patients with acute ischemic stroke are sparse.
Source: Journal of Stroke and Cerebrovascular Diseases - August 24, 2021 Category: Neurology Authors: Jawad H. Butt, Kristian Kragholm, Christina Kruuse, Hanne Christensen, Helle K. Iversen, S øren Paaske Johnsen, Rasmus Rørth, Naja Emborg Vinding, Adelina Yafasova, Christine Benn Christiansen, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Køber, E Source Type: research
Prediction of Intracerebral Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke: Combining Quantitative Parameters on Dual-Energy CT with Clinical Related Factors
At present, intravenous thrombolysis and endovascular therapy are the two main treatment methods of acute ischemic stroke (AIS). The application of intravenous thrombolytic therapy is limited by strict time window restrictions, while endovascular therapy significantly increases the rate of revascularization of arterial occlusion and can improve the clinical prognosis of patients, so it is increasingly applied in clinical practice.1 Despite advances in patient selection for reperfusion therapy for AIS, intracerebral hemorrhage (ICH) remains a serious potential complication, and often occurred within 72 h after surgery.
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2021 Category: Neurology Authors: Ling Li, Mingyue Huo, Tianzi Zuo, Yuhang Wang, Yingmin Chen, Yunfeng Bao Source Type: research
Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis
ConclusionThe results indicate that theophylline does not change the perfusion in potentially salvageable penumbral tissue but only affects the rCBV in the infarct core. In contrast to the penumbra, the infarct core is unlikely to be salvageable, which might explain why theophylline failed in clinical trials.
Source: Clinical Neuroradiology - July 14, 2021 Category: Neurology Source Type: research
ASPECT scores of patients with focal intracerebral hemorrhage were correlated with their short- and medium-term functional outcomes
CONCLUSIONS: A low ASPECTS-H was an indicator of poor short-term and long-term functional outcomes of ICH.PMID:34240679 | DOI:10.1080/01616412.2021.1948747
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Qiuyue Zheng Xiaojie Liu Ke Yan Liang He Yingzhu Chen Source Type: research
Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
This report investigates the role of PKa on hemorrhage and hypertension in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP were fed with a high salt –containing stroke-prone diet to increase blood pressure and induce intracerebral hemorrhage. The roles of PKa on blood pressure, hemorrhage, and survival in SHRSP were examined in rats receiving a PKa inhibitor or plasma prekallikrein antisense oligonucleotide (PK ASO) compared with rats receivin g control ASO. Effects on PKa on the proteolytic cleavage of atrial natriuretic peptide (ANP) were analyzed by tandem mass spectrometry. We show that SHRSP on high-salt...
Source: Translational Stroke Research - July 9, 2021 Category: Neurology Source Type: research
Four Decades of Ischemic Penumbra and Its Implication for Ischemic Stroke
AbstractThe ischemic penumbra defined four decades ago has been the main battleground of ischemic stroke. The evolving ischemic penumbra concept has been providing insight for the development of vascular and cellular approaches as well as diagnostic tools for the treatment of ischemic stroke. rt-PA thrombolytic therapy to prevent the transition of ischemic penumbra to core has been approved for acute ischemic stroke within 3 h and was later recommended to extend to 4.5 h after symptom onset. Mechanical thrombectomy was introduced for the treatment of acute ischemic stroke with a therapeutic window of up to 24 h after s...
Source: Translational Stroke Research - July 5, 2021 Category: Neurology Source Type: research
Application of Mobile Stroke Unit in Prehospital Thrombolysis of Acute Stroke: Experience from China
Conclusion: Despite the small sample size, our preliminary experience of the application of MSU in the prehospital thrombosis therapy seems to indicate a significant reduction in time from call to needle, the efficacy of MSU in the treatment of acute stroke needs further experiment and larger sample size to confirm.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 25, 2021 Category: Neurology Source Type: research
Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance
Hemorrhagic transformation (HT) is a critical issue in thrombolytic therapy in acute ischemic stroke. Damage-associated molecular pattern (DAMP)-stimulated sterile neuroinflammation plays a crucial role in the...
Source: Journal of Neuroinflammation - June 24, 2021 Category: Neurology Authors: Dong-Ling Liu, Zhi Hong, Jing-Ying Li, Yu-Xin Yang, Chu Chen and Jun-Rong Du Tags: Research Source Type: research
Correlation between Immune-Inflammatory Markers and Clinical Features in Patients with Acute Ischemic Stroke
CONCLUSIONS: Immune-inflammatory markers dynamically increased from symptom onset of acute ischemic stroke in patients eligible for thrombolytic therapy. Higher levels of immune-inflammatory markers suggest more in-hospital complications and unfavorable short-term outcomes.PMID:34018169
Source: Acta Neurologica Taiwanica - May 21, 2021 Category: Neurology Authors: Yu-Wei Chu Pei-Ya Chen Shinn-Kuang Lin Source Type: research
