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Nutrition: Diets

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Total 302 results found since Jan 2013.

High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke
This study assesses the neuroinflammatory consequences of a peri-adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNFα and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, peri-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middle cer...
Source: Brain, Behavior, and Immunity - July 10, 2018 Category: Neurology Source Type: research

High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage Clinical Sciences
Conclusions—High serum level of MMP-7 was associated with increased risk of incident spontaneous SAH, independently of the main risk factors for SAH. High serum levels of MMP-2 and MMP-9 did not predict SAH risk.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Martin Soderholm, Gunilla Nordin Fredrikson, Jan Nilsson, Gunnar Engstrom Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice.
In conclusion, the NLRP3 inflammasome was involved in the complex diseases of diabetic stroke. MCC950, the NLRP3 specific inhibitor, ameliorated diabetic mice with cerebral ischemia-reperfusion injury and improved the 28-day survival rate during the recovery stage of ischemic stroke. PMID: 29853850 [PubMed - in process]
Source: Neural Plasticity - June 6, 2018 Category: Neurology Authors: Hong P, Li FX, Gu RN, Fang YY, Lai LY, Wang YW, Tao T, Xu SY, You ZJ, Zhang HF Tags: Neural Plast Source Type: research

Longitudinal Change of Perceived Salt Intake and Stroke Risk in a Chinese Population Clinical Sciences
Conclusions—Change in salt intake was associated with the stroke risk. These data support the dietary recommendation to the reduction of salt intake.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Yun Li, Zhe Huang, Cheng Jin, Aijun Xing, Yesong Liu, Chunmei Huangfu, Alice H. Lichtenstein, Katherine L. Tucker, Shouling Wu, Xiang Gao Tags: Diet and Nutrition, Epidemiology, Lifestyle, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Stroke, Cerebrovascular Diseases and Vascular Cognitive Impairment in Africa.
Abstract With increased numbers of older people a higher burden of neurological disorders worldwide is predicted. Stroke and other cerebrovascular diseases do not necessarily present with different phenotypes in Africa but their incidence is rising in tandem with the demographic change in the population. Age remains the strongest irreversible risk factor for stroke and cognitive impairment. Modifiable factors relating to vascular disease risk, diet, lifestyle, physical activity and psychosocial status play a key role in shaping the current spate of stroke related diseases in Africa. Hypertension is the strongest m...
Source: Brain Research Bulletin - May 25, 2018 Category: Neurology Authors: Akinyemi RO, Owolabi MO, Ihara M, Damasceno A, Ogunniyi A, Dotchin C, Paddick SM, Ogeng'o J, Walker R, Kalaria RN Tags: Brain Res Bull Source Type: research

Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain
Dietary supplement is an attempt to reduce the risk of ischemic stroke in high-risk population. A new mixed vitamin E-Tocovid that mainly contains tocotrienols other than tocopherol, attenuated the progression of white matter lesions by oral in humans. However, the effect of Tocovid on ischemic stroke has not been examined. In the present study, we assessed the therapeutic effects of Tocovid pretreatment on transient middle cerebral artery occlusion (tMCAO) in mice.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2018 Category: Neurology Authors: Jingwei Shang, Hongjing Yan, Yang Jiao, Yasuyuki Ohta, Xia Liu, Xianghong Li, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xiaowen Shi, Yong Huang, Tian Feng, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Koji Abe Source Type: research

High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke
This study assesses the neuroinflammatory consequences of a peri-adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNFα and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, peri-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middle cer...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Source Type: research

High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke.
This study assesses the neuroinflammatory consequences of a peri-adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNFα and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, peri-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middle cer...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Authors: Harrell CS, Zainaldin C, McFarlane D, Hyer MM, Stein D, Sayeed I, Neigh GN Tags: Brain Behav Immun Source Type: research

High Dietary Glycemic Load is Associated with Poor Functional Outcome in Patients with Acute Cerebral Infarction.
CONCLUSIONS: Increased dietary GL and carbohydrate intake were associated with a poor short-term functional outcome after an acute ischemic stroke. PMID: 29629525 [PubMed]
Source: Journal of Clinical Neurology - April 10, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

The Relationship Between the Dietary Inflammatory Index (DII ®) and Incident Depressive Symptoms: A Longitudinal Cohort Study
Depression is a chronic condition with an estimated lifetime prevalence of 14.6% and 11.1% in high- and lower-and-middle-income countries, respectively. (Bromet et al., 2011; Kessler and Bromet, 2013). Moreover, it is estimated that depression is one of the leading sources of disability worldwide (2015; Ferrari et al., 2013), being associated with reduced quality of life and medical morbidity (Ferrari et al., 2013; Kessler and Bromet, 2013; Rackley and Bostwick, 2012). Increasing evidence also shows that depression might confer a higher risk for several non-communicable diseases (e.g., diabetes (Rotella and Mannucci, 2013a...
Source: Journal of Affective Disorders - April 3, 2018 Category: Neurology Authors: Nitin Shivappa, James R. H ébert, Nicola Veronese, Maria Gabriella Caruso, Maria Notarnicola, Stefania Maggi, Brendon Stubbs, Joseph Firth, Michele Fornaro, Marco Solmi Tags: Research paper Source Type: research

The Dysphagia in Stroke Protocol Reduces Aspiration Pneumonia in Patients with Dysphagia Following Acute Stroke: a Clinical Audit
AbstractCough reflex testing has been evaluated as a component of the clinical swallowing assessment as a means of identifying patients at risk of aspiration during swallowing. A previous study by our research group found good sensitivity and specificity of the cough reflex test for identifying patients at risk of aspiration post-stroke, yet its use did not decrease pneumonia rates, contrary to previous reports. The aim of this study was to expand on our earlier work by implementing a clinical management protocol incorporating cough reflex testing within the same healthcare setting and compare patient outcomes to those fro...
Source: Translational Stroke Research - March 30, 2018 Category: Neurology Source Type: research

Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis.
Conclusions Long-term O3FA dietary supplementation prevents the development of intracranial atherosclerosis. This O3FA effect appears to be mediated by its attenuation of NOX subunit expression and NOX activity, therefore reducing ROS production. O3FA dietary supplement shows promising results in the prevention of ICAS. PMID: 29576013 [PubMed - as supplied by publisher]
Source: Neurological Research - March 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Swallowing and Aspiration Risk: A Critical Review of Non Instrumental Bedside Screening Tests.
CONCLUSIONS: The literature is dense with screening methods for assessing the presence of dysphagia but with low predictive value for aspiration risk after acute stroke. A standard, practical, and cost-effective screening tool that can be applied at the bedside and interpreted by a wide range of hospital personnel remains to be developed. This need is highlighted in settings where neither trained personnel in evaluating dysphagia nor clinical instrumentation procedures are available. PMID: 29504298 [PubMed - as supplied by publisher]
Source: Journal of Clinical Neurology - March 7, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury.
Abstract Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to blood-brain barrier (BBB) opening and vascular dysfunction. Tight junction proteins (TJPs), which maintain BBB integrity, are lost in acute ischemia. Although angiogenesis is critical for neurovascular remodeling, less is known about its role in chronic hypoxia. To study the impact of TJP degradation and angiogenesis during pathological progression of WM damage, we used the spontaneously hypertensive/stroke prone rats with unilateral carotid artery occlusion ...
Source: Neurobiology of Disease - February 24, 2018 Category: Neurology Authors: Yang Y, Kimura-Ohba S, Thompson JF, Salayandia VM, Cosse M, Raz L, Jalal FY, Rosenberg GA Tags: Neurobiol Dis Source Type: research