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Specialty: Neurology
Nutrition: Antidoxidants

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Total 165 results found since Jan 2013.

CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression
This study investigated whether CDDO-Im exhibited antidepressant-like activity and elucidated its protective mechanisms in a rat model of PSD, which was produced by middle cerebral artery occlusion (MCAO) followed by 28 days of chronic unpredictable mild stress (CUMS) in conjunction with solitary housing. The results demonstrated that CDDO-Im treatment markedly improved the depressive-like behaviors and reduced neuronal cell loss in the hippocampus, through decreasing the malondialdehyde (MDA) content (indicative of lipid peroxidation), superoxide dismutase (SOD), NF-kB activation, interleukin-6 (IL-6) and interleukin-1b (...
Source: Brain Research - May 15, 2021 Category: Neurology Authors: Xiaoli Hou Huanhuan Liu Yukun Ping Feng Zhang Lingyun Zhi Xinhui Jiang Fuping Zhang Cai Song Zhaohui Zhang Jinggui Song Source Type: research

Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats
Brain Res Bull. 2021 Feb 26:S0361-9230(21)00058-7. doi: 10.1016/j.brainresbull.2021.02.016. Online ahead of print.ABSTRACTThe deacetylase SIRT1 has been reported to play a critical role in regulating neurogenesis, which may be an adaptive processes contributing to recovery after stroke. Our previous work showed that the antioxidant capacity of Momordica charantia polysaccharides (MCPs) could protect against cerebral ischemia/reperfusion (I/R) after stroke. However, whether the protective effect of MCPs on I/R injury is related to NSCs proliferation remains unclear. In the present study, we designed in vivo and in vitro exp...
Source: Brain Research - March 1, 2021 Category: Neurology Authors: Juyun Ma Haidi Fan Heng Cai Zhaoli Hu Xiaoling Zhou Fengying Li Hansen Chen Jiangang Shen Suhua Qi Source Type: research

Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population
Conclusion: The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS in the Dali region.
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Rosmarinic acid protects rats against post-stroke depression after transient focal cerebral ischemic injury through enhancing antioxidant response.
Abstract Rosmarinic acid (RA), a natural polyphenol, possesses potent antioxidant and anti-inflammatory activities. To evaluate the ability of RA to cure ischemic stroke and post-stroke depression (PSD), rats were treated with various doses of RA after cerebral ischemia. Neurological deficits and infarct volume of the brain were measured. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were examined at different time points. In addition, a forced swimming test and sucrose preference test were performed to detect the anti-depressive effects of RA. Our results revealed RA administ...
Source: Brain Research - February 3, 2021 Category: Neurology Authors: Wang J, Wang S, Guo H, Li Y, Jiang Z, Gu T, Su B, Hou W, Zhong H, Cheng D, Zhang X, Fang Z Tags: Brain Res Source Type: research

Amifostine ameliorates cerebral ischaemia-reperfusion injury via p38-mediated oxidative stress and mitochondrial dysfunction.
Authors: Cheng H, Lv M, Mi R, Xue G Abstract Amifostine is a cytoprotective compound that is beneficial in ischaemic stroke cases. However, the neuroprotective effect of amifostine on ischaemia/reperfusion (I/R)-induced brain injury and its underlying mechanism are still poorly understood. Herein, we constructed an animal model of middle cerebral artery occlusion and reperfusion (MCAO/R) injury and an in vitro model of oxygen and glucose deprivation and reperfusion (OGD/R) injury. After administration of amifostine, we found significant improvements in neurological deficits, infarct size, and cerebral oedema. More...
Source: Folia Neuropathologica - January 24, 2021 Category: Neurology Tags: Folia Neuropathol Source Type: research

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury
AbstractErgothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation. 7KC induces a dose-dependent loss of cell viability and ...
Source: NeuroMolecular Medicine - October 16, 2020 Category: Neurology Source Type: research

Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway
AbstractOxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx against SAH-induced oxidative insults and the possible molecular mechanisms. Our data showed that Fx could significantly inhibit SAH-induced reactive oxygen species production and lipid peroxidation, and restore the impairment of endogenous antioxidant enzymes activities. In addition, Fx supplementati...
Source: Molecular Neurobiology - October 7, 2020 Category: Neurology Source Type: research

Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats.
Abstract Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A limiting factor when considering therapies for the nervous tissue is the presence of the blood-brain barrier which stimulates the search for new drug delivery strategies. In this context, nanoencapsulation seems to be a promising alternative. In this work, we compared the protective effects of ...
Source: Brain Research - July 5, 2020 Category: Neurology Authors: Marques MS, Cordeiro MF, Marinho MAG, Vian CO, Vaz GR, Alves BS, Jardim RD, Hort MA, Dora CL, Horn AP Tags: Brain Res Source Type: research

Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia
In this study, we investigated whether targeted expression of the antioxidant extracellular superoxide dismutase (SOD3) within the lung would influence post-ischemic peripheral neutrophil activation and CNS reperfusion injury.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Marc W. Halterman, Nguyen Mai, Viollandi Prifti, Kihong Lim, Michael A. O'Reilly, Minsoo Kim Source Type: research

Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia.
Abstract Cerebral edema is a clinical problem that frequently follows ischemic infarcts. Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling. Transcription of the Abcc8 gene coding for SUR1 depends on the activity of transcriptional factor SP1, which is modulated by the cellular redox environment. Since oxidative stress is implicated in the induced neuronal damage in ischemia and edema formation, the present study aimed to evaluate if the antioxidant resveratrol (RSV) prevents ...
Source: Experimental Neurology - May 3, 2020 Category: Neurology Authors: Alquisiras-Burgos I, Ortiz-Plata A, Franco-Pérez J, Millán A, Aguilera P Tags: Exp Neurol Source Type: research

Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling
In conclusion, peroxynitrite-mediated HMGB1/TLR2 signaling contributes to hemorrhagic transformation, and glycyrrhizin could be a potential adjuvant therapy to attenuate hemorrhagic transformation, possibly through inhibiting the ONOO−/HMGB1/TLR2 signaling cascades.
Source: Translational Stroke Research - December 23, 2019 Category: Neurology Source Type: research

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2.
CONCLUSIONS: IPC provides long-lasting neuroprotection against ischemic brain injury and post-stroke cognitive dysfunction. Nrf2 activation plays a key role in this beneficial outcome and is a promising therapeutic target for the attenuation of ischemic brain injury. PMID: 31812555 [PubMed - as supplied by publisher]
Source: Experimental Neurology - December 4, 2019 Category: Neurology Authors: Yang T, Sun Y, Li Q, Li S, Shi Y, Leak RK, Chen J, Zhang F Tags: Exp Neurol Source Type: research

Hyperuricaemia as a prognostic factor for acute ischaemic stroke
ConclusionsSerum uric acid levels in patients with acute ischaemic stroke are significantly associated with functional prognosis at discharge, although this relationship is nonlinear. In fact, poorer prognosis is associated both with very low and with very high concentrations of uric acid. This suggests a dual role of uric acid in relation to stroke: on the one hand, as an associated risk factor, and on the other, as a possible neuroprotective factor due to its antioxidant effect.ResumenIntroducciónEn el proceso de búsqueda de biomarcadores para el pronóstico del ictus agudo, en los últimos años los estudios realizado...
Source: Neurologia - November 9, 2019 Category: Neurology Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research