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Specialty: Neurology
Nutrition: Antidoxidants
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Total 165 results found since Jan 2013.
Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats
AbstractIschemic stroke is a worldwide disease that seriously threatens human health, and there are few effective drugs to treat it. Dihydromyricetin (DHM) has anti-inflammatory, antioxidant, and antiapoptotic functions. We identified pyroptosis following ischemic stroke. Here, we investigated the effect of DHM on ischemic stroke and pyroptosis. In the first part of the experiment, Sprague-Dawley rats were randomly divided into the sham group and MCAO group. The MCAO model was established by occlusion of the middle cerebral artery for 90 min using a silica gel suture. The ischemic penumbra was used for mRNA sequencing 1...
Source: Neurotherapeutics - August 21, 2023 Category: Neurology Source Type: research
Neuroprotective Effects of Phenolic Antioxidant Tert-butylhydroquinone (tBHQ) in Brain Diseases
This article reviews the effects of tBHQ on neuroinflammation and oxidative stress in recent years and looks into how tBHQ inhibits neuroinflammation and oxidative stress through human, animal, and cell experiments to play a neuroprotective role in Alzheimer’s disease (AD), stroke, depression, and Parkinson’s disease (PD). It is anticipated that this article will be useful as a reference for upcoming research and the creation of drugs to treat brain diseases.
Source: Molecular Neurobiology - August 10, 2023 Category: Neurology Source Type: research
New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD.
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Melatonin mitigates type 1 diabetes ‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects
ConclusionsT1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
Source: Brain and Behavior - June 16, 2023 Category: Neurology Authors: Qian Xu,
Raymond Tak Fai Cheung Tags: ORIGINAL ARTICLE Source Type: research
Tetramethylpyrazine alleviates mitochondrial abnormality in models of cerebral ischemia and oxygen/glucose deprivation Reoxygenation
Exp Neurol. 2023 Jun 10:114468. doi: 10.1016/j.expneurol.2023.114468. Online ahead of print.ABSTRACTTraditional herbal medicine Ligusticum wallichii Franchat (Chuan Xiong) is frequently prescribed and highly recommended to patients with stroke. Rodent studies have demonstrated the neuroprotective effects of its active component tetramethylpyrazine against post-stroke brain injury and highlighted its role in antioxidant, anti-inflammation, and anti-apoptosis activity. Using permanent cerebral ischemia in rats and oxygen/glucose deprivation and reoxygenation (OGDR) in rat primary neuron/glia cultures, this study sheds light ...
Source: Experimental Neurology - June 12, 2023 Category: Neurology Authors: Cheng-Yi Chang Chih-Cheng Wu Pin-Ho Pan Ya-Yu Wang Shih-Yi Lin Su-Lan Liao Wen-Ying Chen Yu-Hsiang Kuan Chun-Jung Chen Source Type: research
Uric acid and neurological disease: a narrative review
Hyperuricemia often accompanies hypertension, diabetes, dyslipidemia, metabolic syndrome, and chronic renal disease; it is also closely related to cardiovascular disease. Moreover, several epidemiological studies have linked hyperuricemia and ischemic stroke. However, uric acid may also have neuroprotective effects because of its antioxidant properties. An association between low uric acid levels and neurodegenerative diseases has been suggested, which may be attributed to diminished neuroprotective effects as a result of reduced uric acid. This review will focus on the relationship between uric acid and various neurologic...
Source: Frontiers in Neurology - June 1, 2023 Category: Neurology Source Type: research
Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke
The aim of this study was to evaluate the relationship between dietary total antioxidant capacity (DTAC) and atherosclerotic carotid stenosis in patients with ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2023 Category: Neurology Authors: Jizi Ma, Xuerong Jia, Yaqian Xia, Min Peng, Yantong Chen, Jingjing Cai, Xinfeng Liu, Gelin Xu Source Type: research
Carnosol Inhibits Cerebral Ischemia-Reperfusion Injury by Promoting AMPK Activation
CONCLUSION: Carnosol has a protective effect on ischemic stroke, and this effect is achieved through AMPK activation. Our study demonstrates the protective effect of carnosol on cerebral ischemia-reperfusion injury and provides a new perspective for the clinical treatment of ischemic stroke.PMID:36775042 | DOI:10.1016/j.brainresbull.2023.02.003
Source: Brain Research Bulletin - February 12, 2023 Category: Neurology Authors: Wen-Chang Xiao Gang Zhou Lu Wan Jun Tu Yong-Jie Yu Zhi-Gang She Chun-Lin Xu Lei Wang Source Type: research
An overview of hyperbaric oxygen preconditioning against ischemic stroke
This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observe...
Source: Metabolic Brain Disease - February 2, 2023 Category: Neurology Source Type: research
