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Specialty: Neurology
Nutrition: Antidoxidants

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Total 165 results found since Jan 2013.

Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
AbstractNeurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer ’s disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease burden, not only in terms of health suffering but also in economic costs. Although the clinical presentations differ for these diseases, a growing body of evidence suggests that oxidative stress and inflammatory responses in brain tissue significantly contribute to their pathology. However, therapies attempting to prevent oxidative damage o...
Source: Molecular Neurobiology - February 27, 2018 Category: Neurology Source Type: research

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia
Exogenous administration of uric acid, a naturally occurring antioxidant that scavenges reactive oxygen species in vasculature, has shown protective efficacy in both rodent models of stroke and human stroke patients in Spain as an adjuvant treatment to mechanical thrombectomy. Before clinical trials can be initiated in the United States, however, confirmation of efficacy in alternative preclinical models is required in accordance with stroke therapy academic industry roundtable-RIGOR criteria. To date, preclinical efficacy has only been established in the acute setting in male rodents.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Nirav Dhanesha, Edwin V ázquez-Rosa, Coral J. Cintrón-Pérez, Daniel Thedens, Alexa J. Kort, Vicky Chuong, Adriana M. Rivera-Dompenciel, Anil K. Chauhan, Enrique C. Leira, Andrew A. Pieper Source Type: research

Brain Photobiomodulation Therapy: a Narrative Review
This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of brain PBM therapy.
Source: Molecular Neurobiology - January 11, 2018 Category: Neurology Source Type: research

Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke
ConclusionCurcumin promotes neuron survival in vivo and in vitro to exert neuroprotective effects against ischemia injury. Moreover, our results for the first time demonstrated curcumin inhibited ischemia‐induced mitochondrial apoptosis via restricting Bax activation, which may be one of the possible mechanisms underlying the neuroprotective effects of curcumin. Curcumin promotes neuron survival in vivo and in vitro to exert neuroprotective effects against ischemia injury. Moreover, our results for the first time demonstrated curcumin inhibited ischemia‐induced mitochondrial apoptosis via restricting Bax activation, w...
Source: Brain and Behavior - December 1, 2017 Category: Neurology Authors: Cai ‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, Rui‐Cong Chen Tags: ORIGINAL RESEARCH Source Type: research

Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway
AbstractInduction of ischemic preconditioning (IPC) represents a potential therapy against cerebral ischemia by activation of adaptive pathways and modulation of mitochondria to induce ischemic tolerance to various cells and tissues. Mitochondrial dysfunction has been ascribed to contribute to numerous neurodegenerative conditions and cerebral ischemia. Nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor that has traditionally been involved in upregulating cellular antioxidant systems to combat oxidative stress in the brain; however, the association of Nrf2 with mitochondria in the brain remains unclear. ...
Source: Translational Stroke Research - November 4, 2017 Category: Neurology Source Type: research

Prognostic value of serum thioredoxin levels in ischemic stroke.
CONCLUSIONS: Serum Trx might be as a biomarker of cardioembolic stroke severity. Increased serum Trx levels could be a useful tool to predict good prognosis in patients with AIS. PMID: 28828929 [PubMed - as supplied by publisher]
Source: Neurological Research - August 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways.
This study was designed in order to investigate the effects between rehabilitation training on the apoptosis of nerve cells and the recovery of neural and motor functions of rats with ischemic stroke by way of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and nuclear factor E2-related factor 2/antioxidant responsive element (Nrf2/ARE) signaling pathways. In total, 110 healthy adult male Sprague-Dawley (SD) rats were selected in order to take part in this study. Ninety SD rats were used in order to establish the middle cerebral artery occlusion (MCAO), among which 80 rats were randomly assigned as part of th...
Source: Brain Research Bulletin - August 23, 2017 Category: Neurology Authors: Jin XF, Wang S, Shen M, Wen X, Han XR, Wu JC, Tang GZ, Wu DM, Lu J, Zheng YL Tags: Brain Res Bull Source Type: research

Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest
AbstractTherapeutic hypothermia (TH) is a neuroprotective treatment post-cardiac arrest but is grossly underutilized. After TH induction, traditional biomarkers and parameters can no long predict clinical outcome due to a lack of understanding of hypothermic response. Innovative approaches to better understand the clinical effect of TH will help to prognosticate outcome and expand beneficial population. Protein glycosylation is an important extracellular post-translational modification, regulating various extracellular signaling pathways. Here, we used glycoproteomics to investigate the association of plasma glycoproteins ...
Source: Translational Stroke Research - August 15, 2017 Category: Neurology Source Type: research

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury
AbstractIntracerebral hemorrhage (ICH) is a cerebrovascular disease with high mortality and morbidity, and the effective treatment is still lacking. We designed this study to investigate the therapeutic effects and mechanisms of melatonin on the secondary brain injury (SBI) after ICH. An in vivo ICH model was induced via autologous whole blood injection into the right basal ganglia in Sprague-Dawley (SD) rats. Primary rat cortical neurons were treated with oxygen hemoglobin (OxyHb) as an in vitro ICH model. The results of the in vivo study showed that melatonin alleviated severe brain edema and behavior disorders induced b...
Source: Translational Stroke Research - August 1, 2017 Category: Neurology Source Type: research

Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo.
CONCLUSIONS: NOB may have a neuroprotective effect on cerebral ischemia, and this protection may be through upregulating Nrf2, HO-1 and downregulating NF-κB expression. PMID: 26874072 [PubMed - as supplied by publisher]
Source: Brain Research - February 10, 2016 Category: Neurology Authors: Zhang L, Zhang X, Zhang C, Bai X, Zhang J, Zhao X, Chen L, Wang L, Zhu C, Cui L, Chen R, Zhao T, Zhao Y Tags: Brain Res Source Type: research

Alpha‐7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress and brain injury in mice with ischemic stroke and bone fracture
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 10, 2014 Category: Neurology Authors: Zhenying Han, Li Li, Liang Wang, Vincent Degos, Mervyn Maze, Hua Su Tags: Original Article Source Type: research

Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats
& Lorraine M Work
Source: Journal of Cerebral Blood Flow - May 1, 2013 Category: Neurology Authors: Emily N J OrdRachel ShirleyJohn D McClureChristopher McCabeEric J KremerI Mhairi MacraeLorraine M Work Tags: antiapoptotic antioxidant combined therapy hypertensive rat transient focal ischemia Source Type: research

An Analog of gamma-Glutamyl-Cysteine Is a More Stable Drug for the Potential Treatment of Stroke (P01.248)
CONCLUSIONS: The data suggest that the D-analog of Gamma-Glu-Cys may serve as a more stable therapeutic agent.Disclosure: Dr. Forman has nothing to disclose. Dr. Ikpa has nothing to disclose. Dr. Garchow has nothing to disclose. Dr. Sukowski has nothing to disclose. Dr. Peterson has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Forman, R., Ikpa, N., Garchow, K., Sukowski, E., Peterson, D. Tags: P01 Cerebrovascular Disease I Source Type: research