Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia

Exogenous administration of uric acid, a naturally occurring antioxidant that scavenges reactive oxygen species in vasculature, has shown protective efficacy in both rodent models of stroke and human stroke patients in Spain as an adjuvant treatment to mechanical thrombectomy. Before clinical trials can be initiated in the United States, however, confirmation of efficacy in alternative preclinical models is required in accordance with stroke therapy academic industry roundtable-RIGOR criteria. To date, preclinical efficacy has only been established in the acute setting in male rodents.

Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Nirav Dhanesha, Edwin V ázquez-Rosa, Coral J. Cintrón-Pérez, Daniel Thedens, Alexa J. Kort, Vicky Chuong, Adriana M. Rivera-Dompenciel, Anil K. Chauhan, Enrique C. Leira, Andrew A. Pieper Source Type: research