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Specialty: Neurology
Condition: ALS

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Total 158 results found since Jan 2013.

Effects of vitamin E on neurodegenerative diseases: an update
Acta Neurobiol Exp (Wars). 2021;81(1):21-33. doi: 10.21307/ane-2021-003.ABSTRACTVitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies ...
Source: Acta Neurobiologiae Experimentalis - May 5, 2021 Category: Neurology Authors: Mehmet Arif Icer Neslihan Arslan Makbule Gezmen-Karadag Source Type: research

Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - May 4, 2021 Category: Neurology Source Type: research

Dynamic changes and mislocalizations of neurodegenerative disease-related proteins in mice stroke model.
In this study, we report that RBPs increased significantly compared with the sham group (*p < 0.05 and **p < 0.01 vs sham), with nuclear depletion and cytoplasmic deposition in neurons in the acute phase of cerebral ischemia. On the other hand, such nucleocytoplasmic mislocalization were not observed in astrocytes. We provide evidence of the alteration of these neurodegeneration-related RBPs after cerebral ischemia, suggesting a potential association between cerebral ischemia and neurodegenerative diseases. PMID: 32360098 [PubMed - as supplied by publisher]
Source: Brain Research - April 27, 2020 Category: Neurology Authors: Liu X, Yamashita T, Shi X, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K Tags: Brain Res Source Type: research

TRNA-derived fragments as sex-dependent circulating candidate biomarkers for Parkinson's disease
Parkinson's Disease (PD) is diagnosed clinically. Reliable non-invasive PD biomarkers are actively sought. Transfer RNAs produce short non-coding RNAs, the tRNA-derived fragments (tRF). tRF have been shown to play diverse roles, including in Amyotrophic Lateral Sclerosis, and the response to ischemic stroke. Rich tRF populations are being reported in biofluids. We explored the possibility that tRF can serve as non-invasive biomarkers for PD.
Source: Parkinsonism and Related Disorders - May 24, 2019 Category: Neurology Authors: Rogan Magee, Eric Londin, Isidore Rigoutsos Source Type: research

Edaravone for the treatment of amyotrophic lateral sclerosis.
Authors: Yoshino H Abstract INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a progressive fatal disorder that affects all skeletal muscles, leading to death, mostly within 2-4 years from onset. To date, the anti-glutamatergic drug riluzole is the only drug that has been approved for the treatment of this disease; however, its efficacy is modest. Oxidative stress is considered to be involved in the pathology of ALS, and in this regard, the free radical scavenger edaravone, which was originally developed for the treatment of acute ischemic stroke, has also been developed for the treatment of ALS. Areas covered: Thi...
Source: Expert Review of Neurotherapeutics - February 28, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography
AbstractThe corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. However, the representation of the entire CST and, specifically, the hand motor area has remained elusive. In this paper we propose a novel method, using manually drawn ROIs based on robustly identifiable neuroanatomic st...
Source: Brain Imaging and Behavior - January 8, 2019 Category: Neurology Source Type: research

Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities.
Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affe...
Source: Epilepsy Curr - November 28, 2018 Category: Neurology Authors: Merelli A, Rodríguez JCG, Folch J, Regueiro MR, Camins A, Lazarowski A Tags: Curr Neuropharmacol Source Type: research

Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - October 1, 2018 Category: Neurology Source Type: research

Stem cell therapy for neurological disorders: A focus on aging.
Abstract Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and th...
Source: Neurobiology of Disease - September 13, 2018 Category: Neurology Authors: Nguyen H, Zarriello S, Coats A, Nelson C, Kingsbury C, Gorsky A, Rajani M, Neal EG, Borlongan CV Tags: Neurobiol Dis Source Type: research

Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - August 10, 2018 Category: Neurology Source Type: research

Everything you always wanted to know about sex and Neurology: neurological disability and sexuality
Conclusions Disability proved to be the main variable related to the presence of sexual dysfunction. Patients with ALS had the worst rates of sexual dysfunction. Patients with MS were similar to the control group. As for the PD group, no patient had normal sexuality. Finally, in stroke patients, the presence of comorbidities and their treatment may have negatively influenced sexuality. These findings showed that patients with chronic neurological diseases have sexual dysfunction and underscore the need for neurologists to know and address this problem.RESUMO Las enfermedades neurol ógicas crónicas generan discapacidad af...
Source: Arquivos de Neuro-Psiquiatria - July 26, 2018 Category: Neurology Source Type: research

Yawning in neurology: a review
ABSTRACT Yawning is a stereotyped physiological behavior that can represent a sign or symptom of several conditions, such as stroke, parakinesia brachialis oscitans, parkinsonism, Parkinson ’ s disease and epilepsy. More rarely, it can occur in patients with intracranial hypertension, brain tumor, multiple sclerosis, migraine, Chiari malformation type I, and amyotrophic lateral sclerosis. Drug-induced yawning is an uncommon clinical condition and yawning in patients with autism or schizophrenia is very rare. The aim of this review is to describe in detail the occurrence of the phenomenon in such conditions, and its ’ p...
Source: Arquivos de Neuro-Psiquiatria - July 26, 2018 Category: Neurology Source Type: research