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Specialty: Neurology
Condition: ALS

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Total 158 results found since Jan 2013.

The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System
CONCLUSION: It was shown that MSCs, independent from origin or administration pathway, can reduce inflammation and help in the recovery and preservation of injured neural tissue. Thus, the use of MSCs represents a potential therapeutic option in the treatment of neurological disorders mediated by inflammatory processes.PMID:36398461 | DOI:10.1159/000528036
Source: Neuro-Degenerative Diseases - November 18, 2022 Category: Neurology Authors: Rodrigo de Andrade Rufino La ís da Silva Pereira-Rufino Thays Cristina Silva Vissoto Irina Kerkis Adriana da Costa Neves Marcelo Cavenaghi Pereira da Silva Source Type: research

HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target
High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory changes upon extracellular secretion expressed in various cells, including neurons and microglia. With the progress of research, neuroinflammation is believed to be involved in the pathogenesis of neurological diseases such as Parkinson's, epilepsy, and autism. As a key promoter of neuroinflammation, HMGB1 is thought to be involved in the pathogenesis of Parkinson's disease, stroke, traumatic brain injury, epilepsy, autism, depression, multiple sclerosis, and amyotrophic lateral sclerosis. However, in the clinic, HMGB1 has not been de...
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research

Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19
Curr Alzheimer Res. 2022 Sep 8. doi: 10.2174/1567205019666220908084559. Online ahead of print.ABSTRACTThe COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a respiratory pathogen with neuroinvasive potential. Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines such as TNF-α, IFN-γ, IL-6 IL-8, IL-10 IL-16, IL-17A, and IL-18 in severely and critically ill COVID-19 patients, which may persist even after apparent recovery from infection. Bioma...
Source: Current Alzheimer Research - September 12, 2022 Category: Neurology Authors: Christos Tsagkaris Muhammad Bilal Irem Aktar Youssef Aboufandi Ahmet Tas Abdullahi Tunde Aborode Tarun Kumar Suvvari Shoaib Ahmad Anastasiia Shkodina Rachana Phadke Marwa S Emhamed Atif Amin Baig Athanasios Alexiou Ghulam Md Ashraf Mohammad Amjad Kamal Source Type: research

FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy
In conclusion, our results reveal the important contribution of FUS aggregates in promoting astrocyte activation in stroke pathology independent of its transcriptional regulation activity. We thus propose that aggregation of FUS is an important pathological process in ischemic stroke and targeting FUS aggregates might be of unique therapeutic value in the development of future treatment strategies for ischemic stroke.PMID:35718207 | DOI:10.1016/j.expneurol.2022.114144
Source: Experimental Neurology - June 19, 2022 Category: Neurology Authors: Shusheng Wu Yuye Yin Longfei Du Source Type: research