Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Neurodegener Dis. 2021 Feb 18:1-10. doi: 10.1159/000513196. Online ahead of print.ABSTRACTBACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention.SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Momin Hua Jia Min Source Type: research

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review.
Abstract BACKGROUND: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention. SUMMARY: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals. Surgical, patient, and anesthetic factors may all lead to the occurrence and development of POCD. The key mechanism of POCD may be the inflammatory response of the central nervous system during su...
Source: Neuro-Degenerative Diseases - February 18, 2021 Category: Neurology Authors: Hua M, Min J Tags: Neurodegener Dis Source Type: research

Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson's Disease.
Abstract BACKGROUND: Parkinson's disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of α-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. SUMMARY: Cumulative evidence implicates that abnormal processing of α-syn will be predicted to lead to pathological changes in PD. Key Messages: In this review, we summarize the structure an...
Source: Neuro-Degenerative Diseases - January 19, 2021 Category: Neurology Authors: He S, Zhong S, Liu G, Yang J Tags: Neurodegener Dis Source Type: research

Herpesvirus Infections and Risk of Parkinson's Disease.
CONCLUSION: Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal. PMID: 33461199 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - January 18, 2021 Category: Neurology Authors: Camacho-Soto A, Faust I, Racette BA, Clifford DB, Checkoway H, Searles Nielsen S Tags: Neurodegener Dis Source Type: research

Effects of Virtual Reality with Motor Imagery Techniques in Patients with Parkinson's Disease: Study Protocol for a Randomized Controlled Trial.
This study is unique in that it will examine the combined effects of VR and MI on motor function, balance and activities of daily living (ADLs) in patients with PD. OBJECTIVE: The aim of this work is to investigate the effects of VR with MI techniques in addition to routine physical therapy on motor function, balance, and ADLs in patients with PD. METHODS: This is a two-armed parallel design, single-blinded (assessor blinded), single-centered, randomized controlled trial, and the study protocol is based on SPIRIT guidelines. Thirty-four patients with PD (Modified Hoehn and Yahr stages I-III) will be randomly allo...
Source: Neuro-Degenerative Diseases - December 17, 2020 Category: Neurology Authors: Kashif M, Ahmad A, Bandpei MAM, Gillani SA, Hanif A, Iram H Tags: Neurodegener Dis Source Type: research

The Expanding Phenotypic Spectrums Associated with ATP1A3 Mutation in a Family with Rapid-Onset Dystonia Parkinsonism.
CONCLUSION: These findings may broaden the phenotypic spectrums of RDP with mutations in the ATP1A3 gene, provide new insights into the diagnosis of RDP, and have implications for genetic counseling. PMID: 33326973 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - December 16, 2020 Category: Neurology Authors: Yuan Y, Ran L, Lei L, Zhu H, Zhu X, Chen H Tags: Neurodegener Dis Source Type: research

Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease.
CONCLUSION: These results provide evidence that rotenone activates the NLRP3 inflammomere and induces pyroptosis. NIM811 protects the cell from rotenone-induced damage and inhibits NLRP3 inflammasome and pyroptosis. NIM811 might serve as a potential therapeutic drug in the treatment of PD. PMID: 33176317 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - November 11, 2020 Category: Neurology Authors: Zhang M, He Q, Chen G, Li PA Tags: Neurodegener Dis Source Type: research

Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study.
CONCLUSIONS: Alterations in the blood volume of small arteries and arterioles (CBVa) were detected in the G2019S-LRRK2 mouse model of PD. The opposite changes in CBVa in the SN and the cortex indicate that PD pathology may have differential effects in different brain regions. Our results suggest the potential value of CBVa as a marker for clinical PD studies. PMID: 33152738 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - November 5, 2020 Category: Neurology Authors: Ning B, Guo G, Gu C, Xu J, Bibic A, He X, Liu H, Chen L, Wei Z, Duan W, Liu P, Lu H, van Zijl PCM, Ross CA, Smith W, Hua J Tags: Neurodegener Dis Source Type: research

Effects of Rivastigmine on Patients with Spinocerebellar Ataxia Type 3: A Case Series of Five Patients.
CONCLUSIONS: Contrary to our hypothesis, we observed no improvement of gait parameters as assessed by SARA and GAIT-Rite®, but coordination abilities were improved. Rivastigmine was well tolerated, but known side effects of rivastigmine, such as deterioration of asthma, may appear. Further trials in larger cohorts are needed to confirm our findings. PMID: 32992315 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - September 28, 2020 Category: Neurology Authors: Grobe-Einsler M, Vogt IR, Schaprian T, Hurlemann R, Klockgether T, Kaut O Tags: Neurodegener Dis Source Type: research

Prefrontal Cortex Transcriptomic Deconvolution Implicates Monocyte Infiltration in Parkinson's Disease.
CONCLUSION AND DISCUSSION: The findings corroborate previous reports and suggest monocytes may be involved in PD pathogenesis. PMID: 32980850 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - September 24, 2020 Category: Neurology Authors: Batchu S Tags: Neurodegener Dis Source Type: research

What Shall We Do for the Patients with Shaky Leg Syndrome? A Review of 23 Patients.
In conclusion, we found that different types of OT and orthostatic myoclonus were diagnosed by electrophysiological evaluation and neuroimaging tools even if they showed the same symptoms as "shaky leg." In addition, it is possible to roughly estimate the response to medication according to the type of OT and the cause. To clarify the pathophysiology of OT, a large number of longitudinal cohort studies and detailed neuroimaging and electrophysiological evaluations are needed. PMID: 32911473 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - September 9, 2020 Category: Neurology Authors: Park S, Lim JG, Chang HJ, Oh E Tags: Neurodegener Dis Source Type: research

Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases.
Abstract BACKGROUND: Neurodegenerative diseases are characterized by a gradual decline in motor and/or cognitive function caused by the selective degeneration and loss of neurons in the central nervous system, but their pathological mechanism is still unclear. Previous research has revealed that many forms of cell death, such as apoptosis and necrosis, occur in neurodegenerative diseases. Research in recent years has noticed that there is a new type of cell death in neurodegenerative diseases: ferroptosis. An increasing body of literature provides evidence for an involvement of ferroptosis in neurodegenerative dis...
Source: Neuro-Degenerative Diseases - August 18, 2020 Category: Neurology Authors: Zhou J, Jin Y, Lei Y, Liu T, Wan Z, Meng H, Wang H Tags: Neurodegener Dis Source Type: research

Publisher's Note.
Authors: PMID: 32674097 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - July 15, 2020 Category: Neurology Tags: Neurodegener Dis Source Type: research

First Recognized Patient with Genetic Vitamin E Deficiency Stable after 36 Years of Controlled Supplement Therapy.
DISCUSSION: In this VED patient, a specified and carefully controlled high-dose vitamin E therapy has prevented any recognizable progression of the neurodegenerative process over more than 3 decades of observation. PMID: 32623435 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - July 2, 2020 Category: Neurology Authors: Kohlschütter A, Finckh B, Nickel M, Bley A, Hübner C Tags: Neurodegener Dis Source Type: research

Analysis of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease Using Quantitative EEG and sLORETA.
CONCLUSION: The results of the present study showed that both classical EEG spectral and EEG source analysis could differentiate patients with and without NPSs, especially psychosis and apathy subdomains. Spectral and sLORETA analyses provided information helpful for a better characterization in patients with NPSs. PMID: 32610338 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - June 30, 2020 Category: Neurology Authors: Shim YS, Shin HE Tags: Neurodegener Dis Source Type: research

Clinical Phenotype of LRRK2 R1441C in 2 Chinese Sisters.
This report is from an ongoing multicentre study in which next-generation sequencing-based PD gene panel testing has so far been conducted on 499 PD patients of various ethnicities from Malaysia. We describe 2 sisters of Chinese ancestry with PD who carry the R1441C mutation in LRRK2 (which in Asians has been reported in only 2 Chinese patients previously), and highlight interesting clinical observations made over a decade of close follow-up. We further explored the feasibility of using a brief, expert-administered rating scale (the Clinical Impression of Severity Index; CISI-PD) to capture data on global disease severity ...
Source: Neuro-Degenerative Diseases - June 23, 2020 Category: Neurology Authors: Lim SY, Lim JL, Ahmad-Annuar A, Lohmann K, Tan AH, Lim KB, Tay YW, Shing YL, Muthusamy KA, Bauer P, Rolfs A, Klein C Tags: Neurodegener Dis Source Type: research

A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease.
A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease. Neurodegener Dis. 2020 Jun 02;19(5-6):204-210 Authors: Wang L, Wang G, Duan Y, Wang F, Lin S, Zhang F, Li H, Li A, Li H Abstract BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease characterized by intracellular α-synuclein (α-Syn) deposition. Alternation of the α-Syn expression level in plasma or erythrocytes may be used as a potential PD biomarker. However, no studies have compared their prognostic value directly with the same cohort. METHODS: Th...
Source: Neuro-Degenerative Diseases - June 1, 2020 Category: Neurology Authors: Wang L, Wang G, Duan Y, Wang F, Lin S, Zhang F, Li H, Li A, Li H Tags: Neurodegener Dis Source Type: research

Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease.
CONCLUSIONS: Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD. PMID: 32454490 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - May 25, 2020 Category: Neurology Authors: Choi JH, Lee JY, Jeon B, Koh SB, Yoon WT, Lee HW, Kwon OD, Kim JW, Kim JM, Ma HI, Kim HT, Baik JS, Cho JW Tags: Neurodegener Dis Source Type: research

CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage.
CONCLUSION: CREB plays a significant role in TLE-associated oxidative neuronal damage and memory impairment. This novel finding provides the evidence of the relationship between CREB and mitochondrial oxidative stress and cognitive dysfunction in epilepsy. Mitochondria-specific antioxidants such as MitoQ may alleviate TLE-associated cognitive dysfunction through activation of CREB and its downstream signaling pathways. PMID: 32417838 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - May 14, 2020 Category: Neurology Authors: Xing J, Han D, Xu D, Li X, Sun L Tags: Neurodegener Dis Source Type: research

Brain Structural Plasticity Associated with Maternal Caregiving in Mothers: A Voxel- and Surface-Based Morphometry Study.
CONCLUSION: These results suggest that the brains of mothers exhibit adaptive structural dynamic plasticity. These findings provide a neuroanatomical basis for understanding how mothers process emotional sensory information during the postpartum period. PMID: 32396895 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - May 11, 2020 Category: Neurology Authors: Zhang K, Wang M, Zhang J, Du X, Chen Z Tags: Neurodegener Dis Source Type: research

A Pilot Study of Urinary Exosomes in Alzheimer's Disease.
CONCLUSION: The differences in levels of Aβ1-42 and P-S396-tau and the quantity of urinary exosomes between AD patients and healthy controls may provide a basis for early diagnosis of AD. PMID: 32375155 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - May 5, 2020 Category: Neurology Authors: Sun R, Wang H, Shi Y, Gao D, Sun Z, Chen Z, Jiang H, Zhang J Tags: Neurodegener Dis Source Type: research

Various Motor and Non-Motor Symptoms in Early Multiple System Atrophy.
CONCLUSIONS: Increasing awareness of various motor and non-motor symptoms may assist clinicians to make an early, accurate diagnosis and to improve management of patients with MSA. We suggest that the diagnostic accuracy can be improved if these features are appropriately reflected in the new diagnostic criteria for MSA. PMID: 32348986 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - April 28, 2020 Category: Neurology Authors: Jung YJ, Kim HJ, Yoo D, Choi JH, Im JH, Yang HJ, Jeon B Tags: Neurodegener Dis Source Type: research

Patients with Lately Diagnosed Cerebrotendinous Xanthomatosis.
CONCLUSION: This cohort is the largest CTX case series in Turkey. All cases showed improvement in gastrointestinal symptoms as a response to CDCA treatment and stabilization on neurological symptoms, i.e., no further progression of neurological abnormalities were noted during this treatment. Therefore, early diagnosis and treatment is crucial in preventing clinical deterioration. PMID: 32349000 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - April 28, 2020 Category: Neurology Authors: Yunisova G, Tufekcioglu Z, Dogu O, Bilgic B, Kaleagasi H, Akca Kalem S, Lohmann E, Gurvit HI, Emre M, Hanagasi HA Tags: Neurodegener Dis Source Type: research

Clinical Features and Risk Factors of Parkinson's Disease in a Population of Khyber Pakhtunkhwa, Pakistan: A Case-Control Study.
This study found a significant association between PD and exposure to pesticides (p
Source: Neuro-Degenerative Diseases - April 13, 2020 Category: Neurology Authors: Tufail M Tags: Neurodegener Dis Source Type: research

Regulation of Protein Synthesis and Apoptosis in Lymphocytes of Parkinson Patients: The Effect of Dopaminergic Treatment.
CONCLUSION: Translational control is altered in PD and hence its evaluation in peripheral blood mononuclear cells may serve as an early marker of apoptosis and indicate the efficacy of the dopaminergic treatment. PMID: 32146463 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - March 5, 2020 Category: Neurology Authors: Pain S, Deguil J, Belin J, Barraud P, Ragot S, Houeto JL Tags: Neurodegener Dis Source Type: research

Voice-Based Classification of Amyotrophic Lateral Sclerosis: Where Are We and Where Are We Going? A Systematic Review.
Abstract BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease. People with ALS demonstrate various speech problems. SUMMARY: We aim to provide an overview of studies concerning the diagnosis of ALS based on the analysis of voice samples. The main focus is on the feasibility of the use of voice and speech assessment as an effective method to diagnose the disease, either in clinical or pre-clinical conditions, and to monitor the disease progression. Specifically, we aim to examine current knowledge on: (a) voice parameters and the data models that can, most effectively, pr...
Source: Neuro-Degenerative Diseases - March 2, 2020 Category: Neurology Authors: Vieira H, Costa N, Sousa T, Reis S, Coelho L Tags: Neurodegener Dis Source Type: research

Effects of Sleep-Related Disorders on the Prognosis of Amyotrophic Lateral Sclerosis.
In this study, we demonstrated the effects of obstructive sleep apnea syndrome (OSAS) on the prognosis of amyotrophic lateral sclerosis (ALS). However, the effects of sleep-related disorders other than breathing problems are still waiting to be delineated. METHODS: In this longitudinal retrospective and prospective study, we investigated 73 patients with ALS compared to 20 healthy subjects, to determine sleep-related disorders and their impact on disease prognosis. RESULTS: In patients with ALS, the mean respiratory disturbance index (RDI) was 28.0/h, which was significantly higher than that in the controls (p
Source: Neuro-Degenerative Diseases - February 27, 2020 Category: Neurology Authors: Reyhani A, Benbir Senel G, Karadeniz D Tags: Neurodegener Dis Source Type: research

Association of Serum Indirect Bilirubin Concentrations with Motor Subtypes of Parkinson's Disease.
Abstract INTRODUCTION: We aimed to investigate the change of serum indirect bilirubin (IBIL) concentrations in patients with Parkinson's disease (PD) and whether IBIL concentrations were associated with the motor subtypes of PD. METHODS: A case-control study was performed to evaluate differences in bilirubin concentrations between 78 PD subjects and 78 controls. Venous blood samples were collected, and total bilirubin (TBIL), direct bilirubin (DBIL), and IBIL concentrations were analyzed between PD subjects and controls. PD patients were classified into three motor subtypes: tremor-dominant (TD), intermediate...
Source: Neuro-Degenerative Diseases - February 17, 2020 Category: Neurology Authors: Li J, Zhao L, Wang Z, Zhao X, Wu J Tags: Neurodegener Dis Source Type: research

An Integrated View on Vascular Dysfunction in Alzheimer's Disease.
Abstract BACKGROUND: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's disease (AD). It is believed to contribute additively to the cognitive impairment and to lower the threshold for the development of dementia. However, accumulating evidence suggests that dysfunction of the cerebral vasculature and AD neuropathology interact in multiple ways. Vascular processes even proceed AD neuropathology, implicating a causal role in the etiology of AD. Thus, the review aims to provide an integrated view on vascular dysfunction in AD. SUMMARY: In AD, the cerebral vasculature undergoes pronounc...
Source: Neuro-Degenerative Diseases - February 13, 2020 Category: Neurology Authors: Klohs J Tags: Neurodegener Dis Source Type: research

Potential Mechanism of Venous System for Leukoaraiosis: From post-mortem to in vivo Research.
Abstract BACKGROUND: Leukoaraiosis (LA), widely accepted as a feature of cerebral small vessel disease, significantly increases the incidence of stroke, dementia, and death. Cerebral small artery disease has been considered as one of the main causes of LA. However, since the term "venous collagenosis" (VC) was proposed in an atrophy research in 1995, there have been pathological and neuroimaging studies proving the association between the venous system and LA in aging, Alz-heimer's disease (AD), and Parkinson's disease. SUMMARY: Autopsy studies confirmed that thickening of the lumen wall in venules,...
Source: Neuro-Degenerative Diseases - February 10, 2020 Category: Neurology Authors: Nan D, Cheng Y, Feng L, Zhao M, Ma D, Feng J Tags: Neurodegener Dis Source Type: research

Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.
CONCLUSION: The progressive decrement of neuropsychological performance is associated with HVL long before the emergence of clinically overt symptoms. In this cohort of healthy individuals, the presence of the APOE-ε4 allele was shown to be an independent predictor of worst hippocampal integrity in asymptomatic cases independently of amyloid positivity. PMID: 31846965 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - December 16, 2019 Category: Neurology Authors: Haller S, Montandon ML, Rodriguez C, Garibotto V, Herrmann FR, Giannakopoulos P Tags: Neurodegener Dis Source Type: research

Is 123I-MIBG Scintigraphy Beneficial or Excessive for the Diagnosis of Parkinson's Disease in the Early Phase?
Abstract INTRODUCTION/OBJECTIVE: In most cases, abnormal cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy increases the probability of a diagnosis of Parkinson's disease (PD) in patients with parkinsonian features. In our study, we validated the additional value of 123I-MIBG scintigraphy beyond providing information on neurological findings and response to dopaminergic therapy for the diagnosis of PDin the early phase. METHODS: We investigated 77 cases of PD (Hoehn and Yahr Stages I-III) and 73 cases of atypical parkinsonian disorder (APD), including 35 patients with multiple system atrophy, 19 with ...
Source: Neuro-Degenerative Diseases - November 11, 2019 Category: Neurology Authors: Ikeda T, Ikenoshita S, Sakamoto F, Shiraishi S, Nakahara K, Masuda T, Yamashita S Tags: Neurodegener Dis Source Type: research

Assessment of the Corticospinal Tract Profile in Pure Lower Motor Neuron Disease: A Diffusion Tensor Imaging Study.
CONCLUSIONS: Our study demonstrates that the CST was impaired in both ALS and pLMND patients, thus suggesting that DTI metrics are a reliable tool in detecting subtle changes of UMN in pLMND patients, also in the absence of clinical and CMCT abnormalities. PMID: 31715609 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - November 11, 2019 Category: Neurology Authors: Sarica A, Valentino P, Nisticò R, Barone S, Pucci F, Quattrone A, Cerasa A, Quattrone A Tags: Neurodegener Dis Source Type: research

Poor Diet, Stress, and Inactivity Converge to Form a "Perfect Storm" That Drives Alzheimer's Disease Pathogenesis.
Poor Diet, Stress, and Inactivity Converge to Form a "Perfect Storm" That Drives Alzheimer's Disease Pathogenesis. Neurodegener Dis. 2019 Oct 10;:1-18 Authors: Pacholko AG, Wotton CA, Bekar LK Abstract North American incidence of Alzheimer's disease (AD) is expected to more than double over the coming generation. Although genetic factors surrounding the production and clearance of amyloid-β and phosphorylated tau proteins are known to be responsible for a subset of early-onset AD cases, they do not explain the pathogenesis of the far more prevalent sporadic late-onset variant of the dis...
Source: Neuro-Degenerative Diseases - October 9, 2019 Category: Neurology Authors: Pacholko AG, Wotton CA, Bekar LK Tags: Neurodegener Dis Source Type: research

Unusual Segregation of APP Mutations in Monogenic Alzheimer Disease.
We report on a 40-year-old woman with a severe cognitive decline starting at 36 years, while her affected relatives presented symptoms onset in the 6th decade. The proband carried an APP missense variant in homozygous state (NM_000484.4: c.2032G>A; NP_000475.1: p.Asp678Asn; rs63750064) and showed a more severe clinical picture than the other AD relatives, as regards the age of onset and the rate of disease progression. This mutation behaves as a semi-dominant trait. The very rare chance of studying APP mutations in the homozygous state demonstrates they are not always dominant and other segregation models are possible. ...
Source: Neuro-Degenerative Diseases - October 1, 2019 Category: Neurology Authors: Mastromoro G, Gambardella S, Marchionni E, Campopiano R, Traversa A, Di Bonaventura C, Pizzuti A Tags: Neurodegener Dis Source Type: research

A Narrative Review of Lifestyle Factors Associated with Parkinson's Disease Risk and Progression.
Abstract Parkinson's disease is a complex slowly progressive neurodegenerative disorder with motor and non-motor symptoms affecting daily living. Despite effective symptomatic treatments, with various degrees of side effects, no disease-modifying therapeutic options presently exist. Symptoms progress, with an accumulating burden, reducing the quality of life and forming the impression that medications are no longer effective. Adopting positive lifestyle behaviours can empower patients, improve the quality of life, alleviate symptoms, and potentially slow disease progression. Lifestyle behaviours including nutritio...
Source: Neuro-Degenerative Diseases - September 4, 2019 Category: Neurology Authors: Nag N, Jelinek GA Tags: Neurodegener Dis Source Type: research

Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease.
Abstract BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative disorder. The striatum is one of the first brain regions that show detectable atrophy in HD. Previous studies using functional magnetic resonance imaging (fMRI) at 3 tesla (3 T) revealed reduced functional connectivity between striatum and motor cortex in the prodromal period of HD. Neuroanatomical and neurophysiological studies have suggested segregated corticostriatal pathways with distinct loops involving different cortical regions, which may be investigated using fMRI at an ultra-high field (7 T) with enhanced sensitivity compare...
Source: Neuro-Degenerative Diseases - August 13, 2019 Category: Neurology Authors: Kronenbuerger M, Hua J, Bang JYA, Ultz KE, Miao X, Zhang X, Pekar JJ, van Zijl PCM, Duan W, Margolis RL, Ross CA Tags: Neurodegener Dis Source Type: research

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease.
CONCLUSIONS: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration. PMID: 31266021 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - July 1, 2019 Category: Neurology Authors: Grimmer T, Goldhardt O, Yakushev I, Ortner M, Sorg C, Diehl-Schmid J, Förstl H, Kurz A, Perneczky R, Miners S Tags: Neurodegener Dis Source Type: research

Novel and Recurring NOTCH3 Mutations in Two Chinese Patients with CADASIL.
CONCLUSIONS: We identified 2 NOTCH3 mutations as likely genetic causes for CADASIL in these 2 patients. Our findings broaden the mutational spectrum of the NOTCH3 gene accountable for CADASIL. Clinical manifestations supplemented with molecular genetic analyses are critical for accurate diagnosis, the provision of genetic counseling, and the development of therapies for CADASIL. PMID: 31212292 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - June 17, 2019 Category: Neurology Authors: Chen X, Deng S, Xu H, Hou D, Hu P, Yang Y, Wen J, Deng H, Yuan L Tags: Neurodegener Dis Source Type: research

Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.
CONCLUSIONS: Our results unravel phenotypic alterations in primary fibroblasts isolated from the TgHD minipig model at the age of 48 months. Importantly, nDNA damage appears to precede these phenotypic alterations. Our results highlight the impact of fibroblasts from TgHD minipigs in studying the molecular mechanisms of HD pathophysiology that gradually occur with age. PMID: 31167196 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - June 4, 2019 Category: Neurology Authors: Smatlikova P, Askeland G, Vaskovicova M, Klima J, Motlik J, Eide L, Ellederová Z Tags: Neurodegener Dis Source Type: research

"A Battle You Would Never Choose to Fight": The Management of Neurodegenerative Diseases as a Societal Challenge.
"A Battle You Would Never Choose to Fight": The Management of Neurodegenerative Diseases as a Societal Challenge. Neurodegener Dis. 2019 Jun 04;:1-3 Authors: Steffen J PMID: 31163425 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - June 3, 2019 Category: Neurology Authors: Steffen J Tags: Neurodegener Dis Source Type: research

Psychosocial Impact of Dysarthria: The Patient-Reported Outcome as Part of the Clinical Management.
CONCLUSIONS: All patients reported a communication complaint, attested by the DIP scores, despite the fact that not all patients, notably PD, ataxic, and PSP patients, had an intelligibility deficit. The DIP should be used in clinical practice to contribute to a holistic evaluation and management of functional communication in patients with dysarthria. PMID: 31112944 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - May 20, 2019 Category: Neurology Authors: Atkinson-Clement C, Letanneux A, Baille G, Cuartero MC, Véron-Delor L, Robieux C, Berthelot M, Robert D, Azulay JP, Defebvre L, Ferreira J, Eusebio A, Moreau C, Pinto S Tags: Neurodegener Dis Source Type: research

Physician and Surrogate Agreement with Assisted Dying and Continuous Deep Sedation in Advanced Dementia in Switzerland.
CONCLUSIONS: The surrogates were more agreeable to considering assisted dying in the setting of advanced dementia than the physicians, and about half of the participants in both groups reported CDS to be an appropriate option for this population. PMID: 31013507 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - April 22, 2019 Category: Neurology Authors: Loizeau AJ, Cohen SM, Mitchell SL, Theill N, Eicher S, Martin M, Riese F Tags: Neurodegener Dis Source Type: research