Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Circulating Biomarkers for Alzheimer's Disease: Unlocking the diagnostic potential in Low-and Middle-Income Countries, focusing on Africa
Neurodegener Dis. 2024 Mar 29. doi: 10.1159/000538623. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families.SUMMARY: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particular...
Source: Neuro-Degenerative Diseases - March 31, 2024 Category: Neurology Authors: Luc Nwamekang Belinga Jeanne Espourteille Yembe Wepnyu Njamnshi Ariole Zafack Zeukang Olivier Rouaud Alfred Kongnyu Njamnshi Gilles Allali Kevin Richetin Source Type: research
Cerebral tau deposition in co-morbid progressive supranuclear palsy and amyotrophic lateral sclerosis: an [18F]-flortaucipir and 7T MRI study
Conclusion In vivo tau PET imaging of an individual with PSP-ALS overlap demonstrated increased tau burden in the motor cortex that was not observed in PSP-RS or control participants. Consistent with prior PET studies, tau burden in PSP-RS was mainly observed in subcortical regions, including the brainstem and basal ganglia. QSM data suggest that off-target binding to iron may account for some but not all of the increased [18F]-flortaucipir uptake in the basal ganglia in PSP-RS. These findings support existing evidence that tau PET imaging can distinguish among PSP subtypes by detecting distinct regional patterns of tau de...
Source: Neuro-Degenerative Diseases - March 25, 2024 Category: Neurology Authors: Ian Cheong Yong Du Gwenn Smith Jun Hua Xu Li Alexander Pantelyat Source Type: research
Cerebral tau deposition in co-morbid progressive supranuclear palsy and amyotrophic lateral sclerosis: an [18F]-flortaucipir and 7T MRI study
Conclusion In vivo tau PET imaging of an individual with PSP-ALS overlap demonstrated increased tau burden in the motor cortex that was not observed in PSP-RS or control participants. Consistent with prior PET studies, tau burden in PSP-RS was mainly observed in subcortical regions, including the brainstem and basal ganglia. QSM data suggest that off-target binding to iron may account for some but not all of the increased [18F]-flortaucipir uptake in the basal ganglia in PSP-RS. These findings support existing evidence that tau PET imaging can distinguish among PSP subtypes by detecting distinct regional patterns of tau de...
Source: Neuro-Degenerative Diseases - March 25, 2024 Category: Neurology Authors: Ian Cheong Yong Du Gwenn Smith Jun Hua Xu Li Alexander Pantelyat Source Type: research
Cerebral tau deposition in co-morbid progressive supranuclear palsy and amyotrophic lateral sclerosis: an [18F]-flortaucipir and 7T MRI study
Conclusion In vivo tau PET imaging of an individual with PSP-ALS overlap demonstrated increased tau burden in the motor cortex that was not observed in PSP-RS or control participants. Consistent with prior PET studies, tau burden in PSP-RS was mainly observed in subcortical regions, including the brainstem and basal ganglia. QSM data suggest that off-target binding to iron may account for some but not all of the increased [18F]-flortaucipir uptake in the basal ganglia in PSP-RS. These findings support existing evidence that tau PET imaging can distinguish among PSP subtypes by detecting distinct regional patterns of tau de...
Source: Neuro-Degenerative Diseases - March 25, 2024 Category: Neurology Authors: Ian Cheong Yong Du Gwenn Smith Jun Hua Xu Li Alexander Pantelyat Source Type: research
