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Total 644 results found since Jan 2013.

The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype
AbstractAltered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion. Hence, the delivery of modified and unmodified miRNA molecules using excellent vehicles is require...
Source: Biotechnology Progress - September 6, 2023 Category: Biotechnology Authors: Sulieman Ibraheem Shelash Al ‐Hawary, Anas Yahya Ali, Yasser Fakri Mustafa, Ria Margiana, Shamsutdinova Maksuda Ilyasovna, Montather F. Ramadan, Sami G. Almalki, Marim Alwave, Safa Alkhayyat, Ali Alsalamy Tags: REVIEW Source Type: research

Paralysed woman able to ‘speak’ through digital avatar in world first
Latest technology uses tiny electrodes on brain surface and is faster than synthesisers which rely on eye trackingA severely paralysed woman has been able to speak through an avatar using technology that translated her brain signals into speech and facial expressions.The advance raises hopes that brain-computer-interfaces (BCIs) could be on the brink of transforming the lives of people who have lost the ability to speak due to conditions such as strokes and amyotrophic lateral sclerosis (ALS).Continue reading...
Source: Guardian Unlimited Science - August 24, 2023 Category: Science Authors: Hannah Devlin Science correspondent Tags: Neuroscience Stroke ChatGPT Artificial intelligence (AI) Technology Computing Health Netherlands World news US news Source Type: news

Watch a person unable to speak for years ‘talk’ using a new brain implant
When it comes to talking, our brain does the heavy lifting. It subconsciously directs the complex coordination of lips, tongue, throat, and jaws we need to pronounce words. And it keeps directing, even in people with paralysis or who are unable to turn these commands into speech. Now, scientists have harnessed this phenomenon to create brain implants that transform this neural activity into text with unprecedented speed and accuracy. In two new studies—both reported today in Nature —the devices enabled two people to “speak” for the first time in more than a decade. The implants produced speech from brain...
Source: ScienceNOW - August 23, 2023 Category: Science Source Type: news

Scientists reconstruct Pink Floyd song by listening to people ’s brainwaves
Breakthrough raises hopes that musicality of natural speech can be restored in patients with disabling neurological conditionsScientists have reconstructed Pink Floyd ’s Another Brick in the Wall by eavesdropping on people’s brainwaves – the first time a recognisable song has been decoded from recordings of electrical brain activity.The hope is that doing so could ultimately help to restore the musicality of natural speech in patients who struggle to communicate because of disabling neurological conditions such as stroke or amyotrophic lateral sclerosis – the neurodegenerative disease that Stephen Hawking was diagn...
Source: Guardian Unlimited Science - August 15, 2023 Category: Science Authors: Linda Geddes Science correspondent Tags: Neuroscience Source Type: news

The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol
Introduction and aims Digital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and neurodegenerative decline. New digital technologies present an opportunity to provide remote, high-frequency monitoring of patients from within their homes. The purpose of the living lab study is to develop novel digital biomarkers of functional impairment in those living with neurodegenerative disease (NDD) and neurological condi...
Source: BMJ Open - August 3, 2023 Category: General Medicine Authors: Crook-Rumsey, M., Daniels, S. J. C., Abulikemu, S., Lai, H., Rapeaux, A., Hadjipanayi, C., Soreq, E., Li, L. M., Bashford, J., Jeyasingh-Jacob, J., Gruia, D. C., Lambert, D., Weil, R., Hampshire, A., Sharp, D. J., Haar, S. Tags: Open access, Neurology Source Type: research

Is exercise actually good for the brain?
There are plenty of reasons to get off your duff and exercise—but is improving your brain one of them? The U.S. Centers for Disease Control and Prevention touts exercise as a way to “ boost brain health , ” while the World Health Organization suggests that about 2 hours of moderate activity or 75 minutes of vigorous activity per week can help improve thinking and memory skills . But new research reveals a more complex picture. One recent review of the literature suggests the studies tying exercise to brain health may have important limitations , including small sample sizes. Othe...
Source: ScienceNOW - June 30, 2023 Category: Science Source Type: news

Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns
Cell Mol Neurobiol. 2023 Jun 25. doi: 10.1007/s10571-023-01377-x. Online ahead of print.ABSTRACTBone marrow-derived mononuclear cells (BMMNCs) have been used for decades in preclinical and clinical studies to treat various neurological diseases. However, there is still a knowledge gap in the understanding of the underlying mechanisms of BMMNCs in the treatment of neurological diseases. In addition, prerequisite factors for the efficacy of BMMNC administration, such as the optimal route, dose, and number of administrations, remain unclear. In this review, we discuss known and unknown aspects of BMMNCs, including the cell ha...
Source: Cellular and Molecular Neurobiology - June 25, 2023 Category: Cytology Authors: Quyen Thi Nguyen Liem Nguyen Thanh Van T Hoang Trang T K Phan Michael Heke Duc M Hoang Source Type: research

Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF- κB/NLRP3 signaling pathway
In this study, lipopolysaccharide (LPS) was used to establish an inflammation model, and the therapeutic effect of TP-5 was evaluated. Behavioral tests showed that TP-5 treatment could improve the performance of LPS-treated mice in the open field and pole test, but not hanging wire test. TP-5 also attenuated neuronal lesions in the brains of LPS-treated mice. TP-5 reduced cytotoxicity and morphological changes in activated microglia. Label-free quantitative analysis indicated that the expression of multiple proteins and the activation of associated signaling pathways were altered by TP-5. Moreover, TP-5 could inhibit LPS-i...
Source: International Immunopharmacology - April 30, 2023 Category: Allergy & Immunology Authors: Si-Jia Peng Ya Feng Xuan Li Xi-Xi Wang Yu Wang Bu-Tian Zhou Ye Liu Te Liu Yun-Cheng Wu Source Type: research