TRNA-derived fragments as sex-dependent circulating candidate biomarkers for Parkinson's disease

Parkinson's Disease (PD) is diagnosed clinically. Reliable non-invasive PD biomarkers are actively sought. Transfer RNAs produce short non-coding RNAs, the tRNA-derived fragments (tRF). tRF have been shown to play diverse roles, including in Amyotrophic Lateral Sclerosis, and the response to ischemic stroke. Rich tRF populations are being reported in biofluids. We explored the possibility that tRF can serve as non-invasive biomarkers for PD.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research