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Total 1074 results found since Jan 2013.

Intra-arterial Thrombectomy versus Standard Intravenous Thrombolysis in Patients with Anterior Circulation Stroke Caused by Intracranial Arterial Occlusions: A Single-center Experience
Background: Severely impaired patients with persisting intracranial occlusion despite standard treatment with intravenous (IV) administration of recombinant tissue plasminogen activator (rtPA) or presenting beyond the therapeutic window for IV rtPA may be candidates for interventional neurothrombectomy (NT). The safety and efficacy of NT by the Penumbra System (PS) were compared with standard IV rtPA treatment in patients with severe acute ischemic stroke (AIS) caused by large intracranial vessel occlusion in the anterior circulation.Methods: Consecutive AIS patients underwent a predefined treatment algorithm based on arri...
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Fabrizio Sallustio, Giacomo Koch, Silvia Di Legge, Costanza Rossi, Barbara Rizzato, Simone Napolitano, Domenico Samà, Natale Arnò, Angela Giordano, Domenicantonio Tropepi, Giulia Misaggi, Marina Diomedi, Costantino Del Giudice, Alessio Spinelli, Sebasti Tags: Original Articles Source Type: research

Troponin T in Prediction of Culprit Lesion Coronary Artery Disease and 1-Year Major Adverse Cerebral and Cardiovascular Events in Patients with Acute Stroke
In this study, we aimed to associate enhanced TnT levels defined by different cutoff values with occurrence of culprit lesion coronary artery disease (CAD) as well as 1-year major adverse cerebral and cardiovascular events (MACCEs). In this cohort study, we investigated 84 consecutive patients with acute ischemic stroke and concomitant MI. TnT levels were measured using a fourth-generation TnT assay. The incidence of culprit lesion CAD was determined by coronary angiography. MACCEs were recorded during 1-year follow-up. Culprit lesion CAD occurred in 55 % of patients, and 1-year MACCE in 37 %. TnT levels above the manufa...
Source: Translational Stroke Research - February 22, 2016 Category: Neurology Source Type: research

How temporal evolution of intracranial collaterals in acute stroke affects clinical outcomes
Conclusions: Not all collateral recruitment is beneficial; delayed collateral recruitment may be different from early recruitment and can result in worse outcomes and higher mortality. Prethrombolysis collateral status and recanalization are determinants of how intracranial collateral evolution affects functional outcomes.
Source: Neurology - February 1, 2016 Category: Neurology Authors: Yeo, L. L. L., Paliwal, P., Low, A. F., Tay, E. L. W., Gopinathan, A., Nadarajah, M., Ting, E., Venketasubramanian, N., Seet, R. C. S., Ahmad, A., Chan, B. P. L., Teoh, H. L., Soon, D., Rathakrishnan, R., Sharma, V. K. Tags: CT, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Risk Reduction of Cerebral Stroke After Stereotactic Radiosurgery for Small Unruptured Brain Arteriovenous Malformations Clinical Sciences
Conclusions— SRS can significantly reduce the risk of stroke in the patients with small unruptured arteriovenous malformations. To definitively determine the clinical benefits of SRS, a longer follow-up will be necessary. However, based on our results, we can recommend SRS for patients who face a latent risk for stroke from this intractable vascular disease.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Hanakita, S., Shin, M., Koga, T., Igaki, H., Saito, N. Tags: Cerebrovascular Malformations, Vascular Disease Clinical Sciences Source Type: research

The disappearing thrombus: An uncommon cause of ischemic stroke
A 46-year-old woman presented with 2 episodes of transient left-sided paresis and hypoesthesia lasting 30 minutes. The emergency department initiated a stroke code due to reoccurrence of symptoms. Workup revealed a platelet count of 1,141,000, and CT angiography showed a large pedunculated thrombus within the right internal carotid artery (figure 1). She underwent emergent plateletpheresis without an anticoagulant (unfractionated heparin, low molecular weight heparin). This was not started at the time of initial presentation because of increased bleeding risk in patients with either reactive or essential thrombocythemia.1 ...
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Lerner, D. P., Graffagnino, C. Tags: Stroke in young adults, All Imaging, Embolism, Infarction Cases Source Type: research

Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke and offers recommendations for stroke management in this challenging new setting: modifications needed for prehospital emergency rescue and hyperacute care; inpatient intensive or stroke units; posthospitalization rehabilitation; follow-up including at-risk family and community; and multispecialty departmental developments in the allied professions.Summary: The severe acute respiratory syndrome coronavirus 2 uses spike proteins binding to tissue angiotensin-converting enz...
Source: Cerebrovascular Diseases - March 23, 2021 Category: Neurology Source Type: research

Relevance of admission hyperglycaemia and diabetes mellitus to efficacy and safety of mechanical thrombectomy in stroke patients
CONCLUSIONS: Diabetes mellitus has a neutral effect on the angiographic and clinical outcomes of mechanical thrombectomy in stroke patients. It does not increase the risk of intracranial haemorrhage after instrumental therapy. It is admission hyperglycaemia, rather than diabetes mellitus, that is a predictor of poor functional status in patients treated with thrombectomy. According to our results, the patient's neurological status, age, and the outcome of thrombectomy are relevant to the functional status in the acute ischaemic stroke period.PMID:36394219 | DOI:10.5603/PJNNS.a2022.0063
Source: Neurologia i Neurochirurgia Polska - November 17, 2022 Category: Neurology Authors: Anetta Lasek-Bal Amadeusz Żak Łukasz Binek Sebastian Student Aleksandra Cie ślik Wies ław Bal Wiktor Rybicki Jolanta Kulawik-Szwajca Source Type: research

Advances in stroke medicine.
Authors: Campbell BC Abstract In recent years, reperfusion therapies such as intravenous thrombolysis and endovascular thrombectomy for ischaemic stroke have dramatically reduced disability and revolutionised stroke management. Thrombolysis with alteplase is effective when administered to patients with potentially disabling stroke, who are not at high risk of bleeding, within 4.5 hours of the time the patient was last known to be well. Emerging evidence suggests that other thrombolytics such as tenecteplase may be even more effective. Treatment may be possible beyond 4.5 hours in patients selected using brain imagi...
Source: Medical Journal of Australia - May 6, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

Safety of percutaneous coronary intervention in patients with acute ischemic stroke/transient ischemic attack and acute coronary syndrome
Conclusions The primary and secondary end points were not enhanced in patients undergoing PCI. Therefore PCI is safe in patients with stroke/TIA and concomitant ACS.
Source: Clinical Research in Cardiology - October 29, 2015 Category: Cardiology Source Type: research

Effects of time delays on the therapeutic outcomes of intravenous thrombolysis for acute ischemic stroke in the posterior circulation: An observational study
ConclusionIrrespective of stroke severity, the therapeutic effects of recanalization after IVT decreased significantly with longer time delays in PCS patients.
Source: Brain and Behavior - January 6, 2019 Category: Neurology Authors: Qiang Huang, Hai ‐qing Song, Qing‐feng Ma, Xiao‐wei Song, Jian Wu Tags: ORIGINAL RESEARCH Source Type: research

Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE
Conclusions: The results indicated higher rate of recurrent stroke in minor stroke or high-risk TIA patients with ICAS than in those without. However, there was no significant difference in the response to the 2 antiplatelet therapies between patients with and without ICAS in the CHANCE trial. Classification of evidence: This study provides Class II evidence that for patients with acute minor stroke or TIA with and without ICAS identified by MRA, clopidogrel plus aspirin is not significantly different than aspirin alone in preventing recurrent stroke.
Source: Neurology - September 28, 2015 Category: Neurology Authors: Liu, L., Wong, K. S. L., Leng, X., Pu, Y., Wang, Y., Jing, J., Zou, X., Pan, Y., Wang, A., Meng, X., Wang, C., Zhao, X., Soo, Y., Johnston, S. C., Wang, Y., For the CHANCE Investigators Tags: ARTICLE Source Type: research

Aortic dissection diagnosed on stroke computed tomography protocol: a case report
ConclusionsWhen acute stroke is suspected due to neurological deficits, plain head CT is the first choice for imaging diagnosis. The addition of cervical CT angiography can reliably exclude stroke due to aortic dissection. CTP can identify ischemic penumbra, which cannot be diagnosed by plain head CT or diffusion-weighted magnetic resonance imaging. These combined stroke CT protocols helped us avoid missing an aortic dissection.
Source: Journal of Medical Case Reports - May 26, 2021 Category: General Medicine Source Type: research

Recanalization with Stent-Retriever Devices in Patients with Wake-Up Stroke INTERVENTIONAL
CONCLUSIONS: Despite successful and rapid recanalization with stent-retriever devices, good clinical outcome in patients with wake-up stroke is achieved in a minority of patients. Clinical outcome remains poor. Bleeding rates were higher compared with recanalization procedures within 6 hours after stroke onset.
Source: American Journal of Neuroradiology - May 15, 2013 Category: Radiology Authors: Stampfl, S., Ringleb, P. A., Haehnel, S., Rocco, A., Herweh, C., Hametner, C., Pham, M., Moehlenbruch, M., Bendszus, M., Rohde, S. Tags: INTERVENTIONAL Source Type: research

Stroke in a Young Woman Caused by Carotid Web (P1.024)
CONCLUSIONS: A carotid web increases stroke risk through thromboembolism. Unlike in other forms of carotid FMD, endarterectomy removes the focus of thrombosis without need for anticoagulation. Alternatively, anticoagulation or antiplatelet therapy might decrease stroke risk but would burden a young patient with increased lifetime risk of bleeding. Study Supported by: N/ADisclosure: Dr. Petrsoric has nothing to disclose. Dr. DeNiro has nothing to disclose. Dr. Labovitz has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Petrsoric, J., DeNiro, L., Labovitz, D. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research