Advances in stroke medicine.

Advances in stroke medicine. Med J Aust. 2019 May;210(8):367-374 Authors: Campbell BC Abstract In recent years, reperfusion therapies such as intravenous thrombolysis and endovascular thrombectomy for ischaemic stroke have dramatically reduced disability and revolutionised stroke management. Thrombolysis with alteplase is effective when administered to patients with potentially disabling stroke, who are not at high risk of bleeding, within 4.5 hours of the time the patient was last known to be well. Emerging evidence suggests that other thrombolytics such as tenecteplase may be even more effective. Treatment may be possible beyond 4.5 hours in patients selected using brain imaging. Endovascular thrombectomy (via angiography) effectively reduces risk of death or dependency in patients with large vessel occlusion (internal carotid, proximal middle cerebral and basilar arteries) if applied within 6 hours of the time they were last known to be well. Endovascular thrombectomy is also beneficial 6-24 hours from the last known well time in selected patients with favourable brain imaging. Thus, some patients with wake-up stroke are now treatable, and protocols for stroke need to include computed tomography (CT) perfusion scan and CT angiography as routine, in addition to the non-contrast CT brain scan. Optimised pre-hospital and emergency department systems (eg, code stroke response teams, pre-notification by ambulance, direct transport from triage to CT scanner)...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research

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In the brief statement regarding the Kelsey departure from the ADHA we read the following. "During [Kelsey's] time, the agency has done much to be proud of, particularly working with stakeholders and the community to provide more than 22 million Australians with an online summary of their key health information through their My Health Record, and to support the introduction of e-prescri bing," ADHA said in a statement.” I think a small fact check of his actual achievements is in order. In his 3 year tenure. 1. He managed one of the worst Government policy implementations of a major initiative that left...
Source: Australian Health Information Technology - Category: Information Technology Authors: Source Type: blogs
CONCLUSION: Thus, diabetes mellitus itself was not an independent factor associated with IAD. A larger IAD was preferentially associated with the presence of PAD, and this association was modified by age. PMID: 31813900 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
ConclusionsThe aim of this case report is to describe our surgical strategy to manage a giant vascular malformation of the tongue and improve quality of life through a median glossectomy with trapezoidal wedge resection of the tongue, as previously described for surgical management of macroglossia.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
ConclusionChildren and adolescents diagnosed with stroke present a worse performance in the electrophysiological and behavioral evaluations of central auditory processing when compared to a control group.ResumoIntroduçãoO processamento auditivo central refere-se à eficiência e eficácia com que o sistema nervoso central utiliza informações auditivas e pode estar alterado em distúrbios neurológicos e lesões cerebrais, como acidentes vasculares cerebrais. No entanto, apesar das evidências de possíveis alterações na populaç&a...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 10 December 2019Source: American Journal of OtolaryngologyAuthor(s): Evette Ronner, Razan Basonbul, Rupal Bhakta, Leila Mankarious, Daniel J. Lee, Michael S. CohenAbstractObjectiveEvaluate the impact of cochlear anomalies on hearing outcomes for pediatric patients with cochlear implants.Study designRetrospective chart review.SettingTertiary care center.Subjects and methodsCharts were retrospectively reviewed for cases where pediatric cochlear implant surgery was performed between 2002 and 2018 at a single, tertiary care institution. Patients were divided into groups based on the presence ...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Conclusions: Our data suggest that thyroid hormones influence angiogenic signaling in MSCs via integrin αvβ3 and further substantiate the anti-angiogenic activity of Tetrac in the tumor microenvironment. PMID: 31816265 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: PD-L1 inhibitors lead to immune mediated thyroiditis, the most frequent endocrine IRAE. In most cases, management is supportive without requiring steroids or discontinuation of immunotherapy. Diffusely increased thyroid 18FDG uptake on PET scan may predict the occurrence of thyroiditis, whereas TPO antibodies may help identify its severity. Thyroiditis may be a biomarker for anti-tumor immune response, highlighting the need to further characterize its underlying mechanism. PMID: 31813343 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Publication date: Available online 9 December 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Prashant Sharma, Elena-Raluca Nicoli, Jenny Serra-Vinardell, Marie Morimoto, Camilo Toro, May Christine V. Malicdan, Wendy J. IntroneSince the initial description of Chediak-Higashi syndrome (CHS), over 75 years ago, several studies have been conducted to underscore the role of the lysosomal trafficking regulator (LYST) gene in the pathogenesis of disease. CHS is a rare autosomal recessive disorder, which is caused by biallelic mutations in the highly conserved LYST gene. The disease is characterized by partial oculocut...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research
Cocco, Fabio / Cagetti, Maria Grazia / Livesu, Roberta / Camoni, Nicole / Pinna, Roberto / Lingstr öm, Peter / Campus, GuglielmoPage 515 - 522Purpose: To evaluate the effect of sugar-free snacks on caries-related factors in 6- to 9-year-old schoolchildren.Materials and Methods: Two hundred seventy-one children at risk for caries as measured through the Cariogram were randomly assigned to three groups consuming twice-daily snacks containing Stevia, maltitol or sugar for 42 days. Parents filled out a standardised questionnaire regarding personal, medical and oral behavioural information. Bleeding on probing, plaque pH a...
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
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