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Total 103 results found since Jan 2013.

Left Ventricular Assist Systems and Strokes- Statins to the Rescue?
The development of durable left ventricular assist systems (LVAS) has been critical in providing an option for management of end-stage heart disease and addressing the increasing gap between demand and supply of donor cardiac allografts for management of end-stage heart disease. The technology also provides an alternative to heart transplantation in many patients. Unfortunately, the long-term use of LVAS has been associated with significant morbidities, the most devastating of which may relate to the thrombogenicity of the artificial devices, leading to ischemic stroke or pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - March 16, 2020 Category: Transplant Surgery Authors: Jignesh Patel Tags: Editorial Source Type: research

Left ventricular assist systems and strokes: Statins to the rescue?
The development of durable left ventricular assist systems (LVASs) has been critical in providing an option for management of end-stage heart disease and addressing the increasing gap between demand and supply of donor cardiac allografts for management of end-stage heart disease. The technology also provides an alternative to heart transplantation in many patients. Unfortunately, the long-term use of LVASs has been associated with significant morbidities, the most devastating of which may relate to the thrombogenicity of the artificial devices, leading to ischemic stroke or pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - March 16, 2020 Category: Transplant Surgery Authors: Jignesh K. Patel Tags: EDITORIAL COMMENTARY Source Type: research

An altered posterior question-mark incision is associated with a reduced infection rate of cranioplasty after decompressive hemicraniectomy.
CONCLUSIONS: The primary goal of this retrospective cohort analysis was to identify adjustable risk factors to prevent post-CP complications. In this analysis, a posterior question-mark incision proved beneficial regarding infection and CP failure. The authors believe that these findings are caused by the better vascularized skin flap due to preservation of the superficial temporal artery and partial preservation of the occipital artery. In this trial, the posterior question-mark incision was identified as an easily and costless adaptable technique to reduce CP failure rates. PMID: 32330877 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 23, 2020 Category: Neurosurgery Authors: Veldeman M, Daleiden L, Hamou H, Höllig A, Clusmann H Tags: J Neurosurg Source Type: research

Natural Y-shaped radial artery graft bypass for a complex middle cerebral artery aneurysm: A case report
We describe a technical method using revascularization with a natural Y-shaped graft that provides a normal variation for a complex MCA aneurysm. A 65-year-old man with a giant thrombosed MCA aneurysm presented with right hemiparesis and aphasia. The patient had a history of clipping surgery for the ipsilateral side of the MCA aneurysm 25 years before, and a de novo aneurysm developed over the previous 18 years.
Source: Journal of Stroke and Cerebrovascular Diseases - May 6, 2020 Category: Neurology Authors: Ryota Sato, Takeshi Mikami, Hime Suzuki, Akinori Yamamura, Yusuke Kimura, Ryo Ukai, Tomoaki Tamada, Yuka Kawata, Yukinori Akiyama, Nobuhiro Mikuni Source Type: research

The effect of Allograft Transplantation of Sertoli Cell on Expression of NF- кB, Bax Proteins, ...
In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) an d apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery.
Source: Iranian Journal of Pharmaceutical Research - May 27, 2020 Category: Drugs & Pharmacology Source Type: research

The Effect of Allograft Transplantation of Sertoli Cell on Expression of NF- кB, Bax Proteins, ...
In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) an d apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery.
Source: Iranian Journal of Pharmaceutical Research - June 8, 2020 Category: Drugs & Pharmacology Source Type: research

To compare intraoperative goal directed fluid therapy by trans-oesophageal Doppler vis- & #224;-vis FloTrac & #8482; in patients undergoing living related renal transplantation-a prospective randomised controlled study
Conclusions: Both TED and FloTrac devices can be used effectively to guide GDFT in RT, However, lesser total fluid was required in the FloTrac group, which may lead to a lesser number of fluid-related postoperative complications.
Source: Indian Journal of Anaesthesia - September 21, 2020 Category: Anesthesiology Authors: Ushkiran Kaur Sandeep Sahu Divya Srivastava Tapas Kumar Singh Prabhakar Mishra Aneesh Srivastava Source Type: research

Transplant Radical Nephrectomy and Transplant Radical Nephroureterectomy for Renal Cancer: Postoperative and Survival Outcomes.
CONCLUSIONS This study reports outcomes of the largest series of transplant radical nephrectomy and nephroureterectomy for malignancies of renal allografts. In the optimized setting, extirpative surgeries appear safe, with favorable long-term oncological and survival outcomes. PMID: 33093437 [PubMed - in process]
Source: Annals of Transplantation - October 23, 2020 Category: Transplant Surgery Authors: Nabavizadeh R, Noorali AA, Makhani SS, Hong G, Holzman S, Patil DH, Kim FY, Tso PL, Turgeon NA, Ogan K, Master VA Tags: Ann Transplant Source Type: research

Molecules, Vol. 26, Pages 3208: Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme
hn Mann Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the pathogenesis of degenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), epilepsy, and a response to traumatic brain injury (TBI) or stroke. COX-2 is also induced in acute pain, depression, schizophrenia, various cancers, arthritis and in acute allograft rejection. Positron emission tomography (PET) imaging allows for the direct measurement of in vivo COX-2 upregulation and thereby enables disease staging, therapy evaluation and aid quantifying target occupa...
Source: Molecules - May 27, 2021 Category: Chemistry Authors: Jaya Prabhakaran Andrei Molotkov Akiva Mintz J. John Mann Tags: Review Source Type: research

Peripheral microvascular dysfunction is associated with plaque progression and adverse long ‐term outcomes in heart transplant patients
ConclusionsPeripheral endothelial dysfunction is associated with increased plaque progression and adverse long-term cardiovascular outcomes in transplant patients. PED assessment might be a useful clinical tool for risk stratification after heart transplantation.
Source: ESC Heart Failure - September 12, 2021 Category: Cardiology Authors: Ilke Ozcan, Takumi Toya, Michel T. Corban, Ali Ahmad, Lilach O. Lerman, Sudhir S. Kushwaha, Amir Lerman Tags: Original Research Article Source Type: research

Determining  optimal donor heart ischemic times in adult cardiac transplantation
ConclusionsThe donor heart IT threshold for survival determined from unbiased statistical modeling occurs at 3  h. With longer preservation times, transplantation with O donor hearts was associated with worse survival.
Source: Journal of Cardiac Surgery - April 30, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Paul C. Tang, Xiaoting Wu, Min Zhang, Donald Likosky, Jonathan W. Haft, Ienglam Lei, Ashraf Abou El Ela, Ming ‐Sing Si, Keith D. Aaronson, Francis D. Pagani Tags: ORIGINAL ARTICLE Source Type: research

Perioperative and long ‐term outcomes of Ross versus mechanical aortic valve replacement
ConclusionsIn this mid-term propensity score-matched analysis, the Ross procedure offers similar perioperative outcomes, freedom from reintervention or valve dysfunction as well as overall survival compared to traditional mAVR but without the morbidity associated with long-term anticoagulation. At specialized centers with sufficient expertize, the Ross procedure should be strongly considered in select patients requiring aortic valve replacement.
Source: Journal of Cardiac Surgery - August 22, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Chelsea D. Wenos, Jeremy L. Herrmann, Lava R. Timsina, Parth M. Patel, John W. Fehrenbacher, John W. Brown Tags: ORIGINAL ARTICLE Source Type: research

Impact of occurrence of cardiac arrest in the donor on long ‐term outcomes of pediatric heart transplantation
ConclusionThe occurrence of donor cardiac arrest has no impact on long-term survival in pediatric heart transplant recipients.
Source: Journal of Cardiac Surgery - November 8, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Sandeep Sainathan, Sameh Said, Tamy Tsujimoto, Feng ‐Chang Lin, Leonardo Mullinari, Mahesh Sharma Tags: ORIGINAL ARTICLE Source Type: research

Platelets at the Vessel Wall in Non-Thrombotic Disease
Circ Res. 2023 Mar 17;132(6):775-790. doi: 10.1161/CIRCRESAHA.122.321566. Epub 2023 Mar 16.ABSTRACTPlatelets are small, anucleate entities that bud from megakaryocytes in the bone marrow. Among circulating cells, platelets are the most abundant cell, traditionally involved in regulating the balance between thrombosis (the terminal event of platelet activation) and hemostasis (a protective response to tissue injury). Although platelets lack the precise cellular control offered by nucleate cells, they are in fact very dynamic cells, enriched in preformed RNA that allows them the capability of de novo protein synthesis which ...
Source: Circulation Research - March 17, 2023 Category: Cardiology Authors: Anu Aggarwal Courtney L Jennings Emily Manning Scott J Cameron Source Type: research