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Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats
CONCLUSION: Dexmedetomidine has a dose-dependent protective effect on cerebral ischemic injury in rats. The neuroprotective effects of dexmedetomidine are achieved, in part, by reducing the oxidative stress response, inhibiting glial overactivation, and inhibiting expression levels of apoptosis-related proteins.PMID:37235497
Source: Alternative Therapies in Health and Medicine - May 26, 2023 Category: Complementary Medicine Authors: Jianhong Lyu Yang Zhou Min Zhang Lingling Tang Xudan Bao Zaijiao Sun Li Huang Liqin Zhao Source Type: research

Primary Extracranial Vertebral Artery Aneurysms
Conclusions: Primary extracranial vertebral artery aneurysms are rare and occur in patients with hereditary disorders. Operative intervention is warranted in symptomatic patients. Exclusion and reconstruction may be performed with open and hybrid techniques with low morbidity and mortality.
Source: Annals of Vascular Surgery - March 27, 2013 Category: Surgery Authors: Mark D. Morasch, Sachin V. Phade, Peter Naughton, Manuel Garcia-Toca, Guillermo Escobar, Ramon Berguer Tags: Clinical Research Source Type: research

Effect of Reduced Sympathetic Hyperactivity on Cardiovascular Risk Factors in Kidney Transplantation Patients
Abstract: Background: Hyperactivity of the sympathetic nervous system caused by chronic kidney disease has detrimental effects on hypertension and cardiovascular morbidity. Kidney transplantation does not ameliorate sympathetic nerve overactivity; however, bilateral nephrectomy eliminates it. The aim of the study was to evaluate the effect of bilateral nephrectomy on risk factors for cardiovascular morbidity and mortality in long-term follow-up. Material and Methods: We studied 24 kidney recipients aged 44 ± 13 years who had undergone native bilateral nephrectomy. The control group included 17 recipients with preserve...
Source: Transplantation Proceedings - May 1, 2013 Category: Transplant Surgery Authors: M. Boratyńska, A.M. Zoń, M. Obremska, K. Pocza̧tek, M. Protasiewicz, M. Magott, M. Klinger Tags: Renal Transplantation Source Type: research

Systematic bias in surgeons' predictions of the donor‐specific risk of liver transplant graft failure
In conclusion, transplant surgeons vary widely in their predictions of the donor‐specific risk of graft failure, and they demonstrate a systematic bias toward inaccurately low estimates of graft failure, particularly for higher risk organs. Liver Transpl, 2013. © 2013 AASLD.
Source: Liver Transplantation - June 19, 2013 Category: Transplant Surgery Authors: Michael L. Volk, Meghan Roney, Robert M. Merion Tags: Original Article Source Type: research

Trigeminal sensory recovery using processed nerve allografts for large continuity defects
The processed nerve allograft, Avance (AxoGen, Alachua, FL), has become a popular alternative to an autograft for the repair of nerve injuries, including the trigeminal nerve. Clinical outcome data on their safety and effectiveness in restoring sensory function of the trigeminal nerve is needed. Sensory assessments of trigeminal nerve injuries were conducted at pre-surgical, 3, 6, and 12 months post-surgical reconstruction with Avance® Nerve Graft. Subjects with at least 6 months of follow-up were included in this analysis. Assessments included brush stroke directional sensation (BSDS), static 2-point discrimination (s2PD...
Source: International Journal of Oral and Maxillofacial Surgery - October 1, 2013 Category: ENT & OMF Authors: J. Zuniga Source Type: research

Intercity deceased donor renal transplantation: A single-center experience from a developing country.
Abstract In a developing country such as India, deceased donor renal transplantation (DDRTx) accounts for only about 1% of all renal transplants (RTx). Our institute initiated an intercity DDRTx in the year 2006, which significantly increased the number of RTx. We retrieved 74 kidneys from 37 deceased donors from various cities of Gujarat from January 2006 to December 2009. We transplanted the allografts in 66 recipients and a retrospective analysis of the donor profile and management and recipient outcome was performed. The mean age of the donors was 43.3 ± 18.8 years. The causes of death included road traffic a...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2013 Category: Urology & Nephrology Authors: Mehta TR, Shah VR, Butala BP, Parikh GP, Parikh BK, Vora KS, Modi MP, Bhosale GP, Kadam PG, Shah PR, Gumber MR, Patel HV, Kute VB, Modi PR, Rizvi SJ, Vanikar AV, Trivedi HL Tags: Saudi J Kidney Dis Transpl Source Type: research

Survival after lung transplantation in systemic sclerosis. A systematic review
Conclusion: The short-term and intermediate-term survival post-lung transplantation are similar to IPAH and ILD patients requiring lung transplantation.
Source: Respiratory Medicine CME - October 9, 2013 Category: Respiratory Medicine Authors: Irfan Y. Khan, Lianne G. Singer, Marc de Perrot, John T. Granton, Shaf Keshavjee, Cathy Chau, Amie Kron, Sindhu R. Johnson Tags: Transplantation Source Type: research

Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus.
CONCLUSIONS: Tight blood sugar control reduces the risk of developing microvascular diabetes complications. The evidence of benefit is mainly from studies in younger patients at early stages of the disease. Benefits need to be weighed against risks including severe hypoglycaemia, and patient training is an important aspect in practice. The effects of tight blood sugar control seem to become weaker once complications have been manifested. However, further research is needed on this issue. Furthermore, there is a lack of evidence from RCTs on the effects of tight blood sugar control in older patient populations or patients w...
Source: Cochrane Database of Systematic Reviews - February 14, 2014 Category: Journals (General) Authors: Fullerton B, Jeitler K, Seitz M, Horvath K, Berghold A, Siebenhofer A Tags: Cochrane Database Syst Rev Source Type: research

The Policy of Placing Older Donors into Older Recipients: Is it Worth the Risk?
ConclusionsUse of older donors (50yrs) in older recipients (60yrs) results in lower 5‐yr survival and freedom from CAV. Caution is required in these cases. Larger studies are warranted to confirm findings.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - May 6, 2014 Category: Transplant Surgery Authors: Yonah Solaiman Tehrani, Zhe Yu, Minh Luu, Frank Liou, Matthew Rafiei, Michele Hamilton, Jon Kobashigawa Tags: Original Article Source Type: research

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