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Condition: Dementia
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Total 174 results found since Jan 2013.

Intravascular large B-cell lymphoma presenting as rapidly progressive dementia and stroke: A case report
Rationale: Intravascular large B-cell lymphoma (IVLBCL) is a rare form of large B-cell non-Hodgkin lymphoma. The diagnosis is challenging and frequently made at biopsy. Here we reported a case of IVLBCL limited to the central nervous system (CNS) presenting with progressive dementia and acute stroke, who was diagnosed by brain biopsy. Patient concerns: A 47-year-old woman was transferred to our hospital with a 6-month history of rapidly progressive dementia, and left limb weakness and numbness for 3 days. She was successively misdiagnosed with inflammatory demyelinating disease and stroke. Her condition deterior...
Source: Medicine - December 3, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research

Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
AbstractBlood pressure variability is an emerging risk factor for dementia but relationships with markers of neurodegeneration and Alzheimer ’s disease risk are understudied. We investigated blood pressure variability over one year and follow-up medial temporal brain volume change in apolipoprotein ϵ4 carriers and non-carriers, and in those with and without Alzheimer’s disease biomarker abnormality. 1051 Alzheimer’s Disease Neuroi maging Initiative participants without history of dementia or stroke underwent 3–4 blood pressure measurements over 12 months and ≥ 1 MRI thereafter. A subset (n = 252) underw...
Source: Brain Imaging and Behavior - September 28, 2021 Category: Neurology Source Type: research

Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets
DISCUSSION: In addition to hypertension, microalbuminuria, arterial stiffness, vascular reactivity and cerebrovascular resistance could be potential treatment targets to halt the development or progression of cerebral SVD.PMID:34550097 | DOI:10.18632/aging.203557
Source: Aging - September 22, 2021 Category: Biomedical Science Authors: Salim Elyas Damilola Adingupu Kunihiko Aizawa Francesco Casanova Kim Gooding Jonathan Fulford Dave Mawson Phillip E Gates Angela C Shore David Strain Source Type: research

Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study
CONCLUSION: Strictly lobar CMBs, as well as WMH volume in anterior and posterior regions, were associated with cognitive decline. Future research focuses are warranted to evaluate interventions that may prevent cognitive decline related to SVD.PMID:34420506 | DOI:10.2174/1567205018666210820125543
Source: Current Alzheimer Research - August 23, 2021 Category: Neurology Authors: Bibek Gyanwali Benedict Lui Chuen Seng Tang Eddie Jun Yi Chong Henri Vrooman Christopher Chen Saima Hilal Source Type: research

Clinical and radiological aspects of bilateral temporal abnormalities: pictorial essay
Abstract The temporal lobes are vulnerable to several diseases, including infectious, immune-mediated, degenerative, vascular, metabolic, and neoplastic processes. Therefore, lesions in the temporal lobes can pose a diagnostic challenge for the radiologist. The temporal lobes are connected by structures such as the anterior commissure, corpus callosum, and hippocampal commissure. That interconnectedness favors bilateral involvement in various clinical contexts. This pictorial essay is based on a retrospective analysis of case files from a tertiary university hospital and aims to illustrate some of the conditions that simul...
Source: Radiologia Brasileira - March 26, 2021 Category: Radiology Source Type: research

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.
Authors: Lu H, Kashani AH, Arfanakis K, Caprihan A, DeCarli C, Gold BT, Li Y, Maillard P, Satizabal CL, Stables L, Wang DJJ, Corriveau RA, Singh H, Smith EE, Fischl B, van der Kouwe A, Schwab K, Helmer KG, Greenberg SM, MarkVCID Consortium Abstract The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) and National Institute on Aging (NIA) in 2016 with the goals of developing and validating biomarkers for the cerebral small vessel diseases associated with the vascular contributions to cognitive impairment and dementia (VCID). Rigorously ...
Source: The Journal of Alzheimers Association - January 24, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Potential applications of FDG-PET/MRI in detecting vascular dementia
Conclusions: FDG-PET/MRI may be a valuable tool in the diagnosis of VaD. However, the paucity of data in the field necessitates a further analysis of its similarity to FDG-PET/CT in results. Novel studies should be conducted to explore various scanners, patient populations, and MRI protocols to better inform the identification of VaD.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Bhattaru, A., Zhang, V., Hancin, E., Borja, A., Rojulpote, K. V., Werner, T., Revheim, M.-E., Alavi, A. Tags: Educational Exhibits Poster Session I Source Type: research

Value of SPECT/CT over planar imaging during Tc-99m MDP triple phase bone scintigraphy for detection of osteomyelitis in patients with stage IV pressure ulcers
Conclusion: SPECT/CT imaging has a significant added diagnostic value over planar imaging in accurately detecting osseous involvement with stage IV pressure ulcers. It significantly reduced equivocal results by accurate uptake localization, reducing false positive results due to other associated pathologies and reducing false negative results due to overlap by other structures or difficult patient positioning.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Nasr, H., Alfawzan, T., Alqarni, A., Farghaly, H. Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research

Blood test identifies risk of disease linked to stroke and dementia
A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person ’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S. CSVD can lead to dementia and stroke, but currently it can only be diagnosed with an MRI scan of the brain.“The hope is that this will spawn a novel diagnostic test that clinicians can start to use as a quantitative measure of brain health in people who are at risk of developing cerebral small vessel disease,” said Dr. Jason Hinman, a UCLA assistant professor of neurology and lead author of t...
Source: UCLA Newsroom: Health Sciences - February 1, 2020 Category: Universities & Medical Training Source Type: news

The Prevalence and Factors Associated with Antiepileptic Drug Use in US Nursing Home Residents
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - December 15, 2019 Category: Geriatrics Source Type: research

Application of an Imaging-Based Sum Score for Cerebral Amyloid Angiopathy to the General Population: Risk of Major Neurological Diseases and Mortality
Conclusions: Our results suggest that in this community-dwelling population, a higher CAA score is related to cognitive impairment and a higher risk of stroke, dementia, and death. The composite CAA score can be used to practically quantify the severity of vascular brain injury.
Source: Frontiers in Neurology - December 5, 2019 Category: Neurology Source Type: research

Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors.
Abstract Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman et al 2015). G-SPECT-I achieves data completeness in the scan region of interest by making small translations of the patient bed while using projections from all bed positions together for image reconstruction. A strategy to restrict the number of bed translations is d...
Source: Physics in Medicine and Biology - November 25, 2019 Category: Physics Authors: Chen Y, Goorden MC, Vastenhouw B, Beekman FJ Tags: Phys Med Biol Source Type: research