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Total 1564 results found since Jan 2013.

Machine learning identifies stroke features between species
Conclusion: Our findings reveal that the segmentation produced by our proposed framework using 24 h MRI rat data strongly correlated with the final stroke volume, denoting a predictive effect. In addition, we show for the first time that the stroke imaging features can be directly translated between species, allowing identification of acute stroke in humans using the model trained on animal data. This discovery reduces the gap between the clinical and preclinical fields, unveiling a novel approach to directly co-analyze clinical and preclinical data. Such methods can provide further biological insights into human stroke an...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Salvador Castaneda-Vega, Prateek Katiyar, Francesca Russo, Kristin Patzwaldt, Luisa Schnabel, Sarah Mathes, Johann-Martin Hempel, Ursula Kohlhofer, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Ulf Ziemann, Christian la Fougere, Ulrike Ernemann, Tags: Research Paper Source Type: research

HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.
Abstract Stroke is the leading cause of disability worldwide. HSPA12B, a heat-shock protein recently identified expression specifically in endothelial cells, is able to promote angiogenesis. Here, we have investigated its effects on functional recovery at chronic phase of ischaemic stroke. Ischaemic stroke was induced by 60 min. of middle cerebral artery occlusion in transgenic mice with overexpression of HSPA12B (HSPA12B Tg) and wild-type littermates (WT). HSPA12B Tg mice demonstrated a significant higher survival rate than WT mice within 28 days post-stroke. Significant improved neurological functions, increased...
Source: J Cell Mol Med - February 7, 2018 Category: Molecular Biology Authors: Zhao Y, Liu C, Liu J, Kong Q, Mao Y, Cheng H, Li N, Zhang X, Li C, Li Y, Liu L, Ding Z Tags: J Cell Mol Med Source Type: research

Serum levels of omentin-1 association with early diagnosis, lesion volume and severity of acute ischemic stroke.
CONCLUSION: The data indicated a negative relation between omentin-1 level and risk of ischemic stroke. The omentin-1 could be promising indicator of stroke and its severity. PMID: 29880272 [PubMed - as supplied by publisher]
Source: Cytokine - June 4, 2018 Category: Molecular Biology Authors: Yue J, Chen J, Wu Q, Liu X, Li M, Li Z, Gao Y Tags: Cytokine Source Type: research

A mouse brain-based multi-omics integrative approach reveals potential blood biomarkers for ischemic stroke.
Abstract Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke diagnosis, prognosis, and treatment. Data integration from high-throughput -omics techniques has become crucial to unraveling key interactions among different molecular elements in complex biological contexts, such as ischemic stroke. Thus, we used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics datasets ob...
Source: Molecular and Cellular Proteomics : MCP - August 30, 2020 Category: Molecular Biology Authors: Simats A, Ramiro L, García-Berrocoso T, Briansó F, Gonzalo R, Martín L, Sabé A, Gill N, Penalba A, Colome N, Sánchez A, Canals F, Bustamante A, Rosell A, Montaner J Tags: Mol Cell Proteomics Source Type: research

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 25, 2015 Category: Molecular Biology Source Type: research

Stroke injury, cognitive impairment and vascular dementia
This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - January 25, 2016 Category: Molecular Biology Source Type: research

Delayed administration of guanosine improves long ‑term functional recovery and enhances neurogenesis and angiogenesis in a mouse model of photothrombotic stroke.
Delayed administration of guanosine improves long‑term functional recovery and enhances neurogenesis and angiogenesis in a mouse model of photothrombotic stroke. Mol Med Rep. 2017 Apr 27;: Authors: Deng G, Qiu Z, Li D, Fang Y, Zhang S Abstract Guanosine (GUO) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to investigate whether delayed administration of GUO improved long‑term functional recovery following stroke, as well as to explore the potential underlying mechanisms. GUO (8 mg/kg) or a vehicle was administered intraperitone...
Source: Molecular Medicine Reports - May 12, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Application of 68Ga-PRGD2 PET/CT for αvβ3-integrin Imaging of Myocardial Infarction and Stroke
Conclusions: 68Ga-PRGD2 uptake was observed around the ischemic region in both MI and stroke patients, which was correlated with the disease phase and severity. The different image patterns and uptake levels in MI and stroke patients warrant further investigations.
Source: Theranostics - November 15, 2014 Category: Molecular Biology Authors: Yi Sun, Yong Zeng, Yicheng Zhu, Feng Feng, Weihai Xu, Chenxi Wu, Bing Xing, Weihong Zhang, Peiling Wu, Liying Cui, Renzhi Wang, Fang Li, Xiaoyuan Chen, Zhaohui Zhu Tags: Research Paper Source Type: research

Peripheral biomarkers of stroke: Focus on circulatory microRNAs
This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - August 9, 2016 Category: Molecular Biology Source Type: research

Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke
This study investigated the effects of HSPA12A on ischaemic stroke in mice. Ischaemic stroke was induced by left middle cerebral artery occlusion for 1 h followed by blood reperfusion. We observed that HSPA12A was highly expressed in brain neurons, and neuronal HSPA12A expression was downregulated by ischaemic stroke and stroke-associated risk factors (aging, obesity and hyperglycaemia). To investigate the functional requirement of HSPA12A in protecting ischaemic brain injury, HSPA12A knockout mice (Hspa12a −/−) were generated. Hspa12a −/− mice exhibited an enlarged infarct volume and aggravated neurological defi...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - March 22, 2018 Category: Molecular Biology Source Type: research

Neural Stem Cell Transplantation into a Mouse Model of Stroke.
Abstract Stroke is the fifth leading cause of death among Americans each year. Current standard-of-care treatment for stroke deploys intravenous tissue-type plasminogen activator (tPA), mechanical thrombolysis, or delivery of fibrinolytics. Although these therapies have reduced stroke-induced damage, therapeutic options still remain limited. Transplantation of patient-specific neural stem (NS) cells represents a promising strategy for the treatment of stroke. Basic science research has shown that transplanted NS cells can differentiate in the brain of rodent models of stroke and promote behavioral recovery. Clinic...
Source: Mol Biol Cell - June 10, 2019 Category: Molecular Biology Authors: De Los Angeles A Tags: Methods Mol Biol Source Type: research

Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research

Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke.
Abstract MicroRNAs (miRNAs or miRs) are small (19-23 nt) non-coding RNA molecules that are endogenous regulators of gene expression. Previous studies have found that some miRNAs are related to the progression of ischemia in the cerebral artery. Furthermore, a recent study found a significant association between miRNA single nucleotide polymorphisms (SNPs) and the risk of ischemic stroke. Therefore, it may be valuable to investigate associations between megakaryocyte formation-related miRNA polymorphisms and the prevalence of ischemic stroke. We thus conducted a case-control study of 1,000 individuals who were s...
Source: International Journal of Molecular Medicine - May 24, 2016 Category: Molecular Biology Authors: Choi GH, Ko KH, Kim JO, Kim J, Oh SH, Han IB, Cho KG, Kim OJ, Bae J, Kim NK Tags: Int J Mol Med Source Type: research

HSPA12B promotes functional recovery after ischaemic stroke through an eNOS ‐dependent mechanism
Abstract Stroke is the leading cause of disability worldwide. HSPA12B, a heat‐shock protein recently identified expression specifically in endothelial cells, is able to promote angiogenesis. Here, we have investigated its effects on functional recovery at chronic phase of ischaemic stroke. Ischaemic stroke was induced by 60 min. of middle cerebral artery occlusion in transgenic mice with overexpression of HSPA12B (HSPA12B Tg) and wild‐type littermates (WT). HSPA12B Tg mice demonstrated a significant higher survival rate than WT mice within 28 days post‐stroke. Significant improved neurological functions, increased sp...
Source: Journal of Cellular and Molecular Medicine - February 7, 2018 Category: Molecular Biology Authors: Yanlin Zhao, Chang Liu, Jiali Liu, Qiuyue Kong, Yu Mao, Hao Cheng, Nan Li, Xioajin Zhang, Chuanfu Li, Yuehua Li, Li Liu, Zhengnian Ding Tags: Original Article Source Type: research

Current advances in ischemic stroke research and therapies
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Derek Barthels, Hiranmoy DasAbstractWith more than 795,000 cases occurring every year, stroke has become a major problem in the United States across all demographics. Stroke is the leading cause of long-term disability and is the fifth leading cause of death in the US. Ischemic stroke represents 87% of total strokes in the US, and is currently the main focus of stroke research. This literature review examines the risk factors associated with ischemic stroke, changes in cell morphology and s...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - September 16, 2018 Category: Molecular Biology Source Type: research