Filtered By:
Specialty: Molecular Biology

This page shows you your search results in order of relevance. This is page number 16.

Order by Relevance | Date

Total 1564 results found since Jan 2013.

AMPK: Potential Therapeutic Target for Ischemic Stroke
5'-AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase group, is universally distributed in various cells and organs. It is a significant endogenous defensive molecule that responds to harmful stimuli, such as cerebral ischemia, cerebral hemorrhage, and, neurodegenerative diseases (NDD). Cerebral ischemia, which results from insufficient blood flow or the blockage of blood vessels, is a major cause of ischemic stroke. Ischemic stroke has received increased attention due to its '3H' effects, namely high mortality, high morbidity, and high disability. Numerous studies have revealed that act...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Shuai Jiang, Tian Li, Ting Ji, Wei Yi, Zhi Yang, Simeng Wang, Yang Yang, Chunhu Gu Tags: Review Source Type: research

An Alternative Model of Laser-Induced Stroke in the Motor Cortex of Rats.
Conclusions: The data presented in this paper show that the model of laser irradiation can serve as an effective method of inducible brain cortical infarction and may lead to a better understanding of the pathophysiology of ischemic stroke and the future development of new drugs and other neuro-protective agents. PMID: 31130825 [PubMed]
Source: Biological Procedures Online - May 28, 2019 Category: Molecular Biology Authors: Boyko M, Kuts R, Gruenbaum BF, Tsenter P, Grinshpun J, Frank D, Zvenigorodsky V, Melamed I, Brotfain E, Zlotnik A Tags: Biol Proced Online Source Type: research

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins
AbstractIschemic stroke is the leading cause of human disability and mortality in the world. The main problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons in the potentially salvageable transition zone (penumbra), which is expanding after brain damage. The data on molecular mechanisms of penumbra formation and expression of diverse signaling proteins in the penumbra during first 24  h after ischemic stroke are discussed. Two basic features of cell death regulation in the ischemic penumbra were observed: (1) both apoptotic and anti-apoptotic proteins are simultaneously over-expresse...
Source: Apoptosis - June 28, 2019 Category: Molecular Biology Source Type: research

Intracarotid cold saline infusion contributes to neuroprotection in MCAO ‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1.
Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1. Mol Med Rep. 2019 Aug 21;: Authors: Wang D, Huang Z, Li L, Yuan Y, Xiang L, Wu X, Ni C, Yu W Abstract Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) in the underlying mechanism of ICSI is not fully understood; therefore, we used the rat middle cerebral artery occlusion (MCAO) model to investigate the neuroprotective ...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Relationship between Erk1/2 signal pathway and nerve cell apoptosis rats with ischemic stroke.
Authors: Gao X, Li H, Dong Z, Zhang P, Liu R, Xue Y, Shi N Abstract To investigate the relationship between the Erk1/2 signal pathway and neuronal apoptosis in ischemic stroke rats. Male SD(Sprague Dawley)  rats (n = 24) were randomly divided into three groups, each containing 8 rats: sham-operated group, MCAO(Midle cerebral artery oclusion)  group, and MCAO + U0126 intervention group (U0126 group). In in vitro trial, primary cortical nerve cells were divided into three groups: control group, OGD(Oxygen and glucose deprivation)  group, and U0126 intervention group (U0126 group). In vivo protein expression levels...
Source: Cellular and Molecular Biology - December 29, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke.
Abstract Blood-brain barrier (BBB) integrity injury within the thrombolytic time window is becoming a critical target to reduce haemorrhage transformation (HT). We have previously reported that BBB damage was initially damaged in non-infarcted striatum after acute ischaemia stroke. However, the underlying mechanism is not clear. Since acute ischaemic stroke could induce a significant increase of dopamine release in striatum, in current study, our aim is to investigate the role of dopamine receptor signal pathway in BBB integrity injury after acute ischaemia using rat middle cerebral artery occlusion model. Our dat...
Source: J Cell Mol Med - July 5, 2020 Category: Molecular Biology Authors: Wang Y, Wang X, Zhang X, Chen S, Sun Y, Liu W, Jin X, Zheng G Tags: J Cell Mol Med Source Type: research

Isolation and Quantification of Blood Apoptotic Bodies, a Non-invasive Tool to Evaluate Apoptosis in Patients with Ischemic Stroke and Neurodegenerative Diseases.
Conclusions: This easy, minimally time consuming and effective procedure for isolating and quantifying plasma apoptotic bodies could help physicians to implement the use of such vesicles as a non-invasive tool to monitor apoptosis in patients with cerebrovascular and neurodegenerative diseases for prognostic purposes and for monitoring disease activity. PMID: 32765191 [PubMed]
Source: Biological Procedures Online - August 13, 2020 Category: Molecular Biology Authors: Serrano-Heras G, Díaz-Maroto I, Castro-Robles B, Carrión B, Perona-Moratalla AB, Gracia J, Arteaga S, Hernández-Fernández F, García-García J, Ayo-Martín O, Segura T Tags: Biol Proced Online Source Type: research

Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway.
In this study, we used the tMCAO mice model to investigate the role of circCCDC9 in the pathogenesis of stroke. We found that the expression of circCCDC9 was significantly decreased in the brains of tMCAO mice. The Evens blue and brain water content were significantly higher in the Pre-IR and Pre-IR+Vector mice, while these patterns were partially reversed by overexpression of circCCDC9. The nitrite content and eNOS expression were decreased in the Pre-IR and Pre-IR+Vector groups, which was restored by circCCDC9 overexpression. Overexpression of circCCDC9 also inhibited the expression of Caspase-3, Bax/Bcl-2 ratio and the ...
Source: J Cell Mol Med - October 29, 2020 Category: Molecular Biology Authors: Wu L, Xu H, Zhang W, Chen Z, Li W, Ke W Tags: J Cell Mol Med Source Type: research

COVID ‑19 and ischemic stroke: Mechanisms of hypercoagulability (Review).
COVID‑19 and ischemic stroke: Mechanisms of hypercoagulability (Review). Int J Mol Med. 2021 Mar;47(3): Authors: Zhang S, Zhang J, Wang C, Chen X, Zhao X, Jing H, Liu H, Li Z, Wang L, Shi J Abstract During the coronavirus disease 2019 (COVID‑19) pandemic, some patients with severe COVID‑19 exhibited complications such as acute ischemic stroke (AIS), which was closely associated with a poor prognosis. These patients often had an abnormal coagulation, namely, elevated levels of D‑dimer and fibrinogen, and a low platelet count. Certain studies have suggested that COVID‑19 induces AIS by promoti...
Source: International Journal of Molecular Medicine - January 17, 2021 Category: Molecular Biology Authors: Zhang S, Zhang J, Wang C, Chen X, Zhao X, Jing H, Liu H, Li Z, Wang L, Shi J Tags: Int J Mol Med Source Type: research

Foxo1-induced miR-92b down-regulation promotes blood-brain barrier damage after ischaemic stroke by targeting NOX4
This study aimed to probe into whether miR-92b influenced the BBB damage after ischaemic stroke by regulating NOX4 expression. Here, miR-92b expression was lessened in the ischaemic brains of rats and oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs). In middle cerebral artery occlusion (MCAo) rats, miR-92b overexpression relieved the ameliorated neurological function and protected the BBB integrity. In vitro model, miR-92b overexpression raised the viability and lessened the permeability of OGD-induced BMECs. miR-92b targeted NOX4 and regulated the viability and permeability of OGD-ind...
Source: J Cell Mol Med - May 6, 2021 Category: Molecular Biology Authors: Jian Shen Ganglei Li Yu Zhu Qingsheng Xu Hengjun Zhou Kangli Xu Kaiyuan Huang Renya Zhan Jianwei Pan Source Type: research

Task-Oriented Circuit Training as an Alternative to Ergometer-Type Aerobic Exercise Training after Stroke
J Clin Med. 2021 May 30;10(11):2423. doi: 10.3390/jcm10112423.ABSTRACTModerate-intensity aerobic exercise training is an important treatment strategy to enhance functional recovery and decrease cardiometabolic risk factors after stroke. However, stroke related impairments limit access to ergometer-type exercise. The aims of the current study were (1) to evaluate whether our task-oriented circuit training protocol (intermittent functional training; IFT) could be used to sustain moderate-intensity aerobic workloads over a 10-week intervention period, and (2) to investigate its preliminary effects on cardiorespiratory fitness...
Source: Molecular Medicine - June 2, 2021 Category: Molecular Biology Authors: Liam P Kelly Augustine J Devasahayam Arthur R Chaves Marie E Curtis Edward W Randell Jason McCarthy Fabien A Basset Michelle Ploughman Source Type: research

IL-38 as an early predictor of the ischemic stroke prognosis
CONCLUSION: The results indicate that tPA could meaningfully increase the IL-38 serum level. Also, a negative correlation has been found between IL-38 serum changes in response to tPA and mRS. Since the lower changes in IL-38 serum level result in a poorer prognosis, we conclude that IL-38 serum changes might be a novel early predictor factor for ischemic stroke prognosis.PMID:34157522 | DOI:10.1016/j.cyto.2021.155626
Source: Cytokine - June 22, 2021 Category: Molecular Biology Authors: Maryam Zare Rafie Abdolreza Esmaeilzadeh Abdolreza Ghoreishi Safa Tahmasebi Elham Faghihzadeh Reza Elahi Source Type: research